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81.
Calandrella N Scarsella G Pescosolido N Risuleo G 《Molecular and cellular biochemistry》2007,301(1-2):155-163
Ocular hypertension is a symptom of a glaucomatous condition characterized by a severe vision decrease. Blindness caused by
the apoptotic death of the retinal ganglion cells and of the astrocytes of the optic nerve may eventually result. Experimental
hypertension was induced by inoculation of methylcellulose in the anterior chamber. Chromatin staining, TUNEL assay, and inter-nucleosomal
DNA fragmentation observed in retina and optic nerve strongly suggest that hypertension causes apoptosis. Immunolocalization
of the fibrillary acidic glial protein, specific of cell stress, and caspase-3 in the same tissues, further support this mode
of cell death. Activation of the ubiquitin dependant proteolytic system was also observed. Protection from apoptosis exerted
by administration of the peroxide scavenger trolox, suggests that the apoptotic pathway is activated by an oxidative stress.
The data presented here show that the experimental hypertensive insult induces degenerative and apoptotic events comparable
to those observed in human glaucoma. 相似文献
82.
Parati G Lombardi C Narkiewicz K 《American journal of physiology. Regulatory, integrative and comparative physiology》2007,293(4):R1671-R1683
Several studies have shown the occurrence of an independent association between obstructive sleep apnea syndrome (OSAS) and cardiovascular disease, including arterial hypertension, ischemic heart disease, and stroke. The pathogenesis of the cardiovascular complications of OSAS is still poorly understood, however. Several mechanisms are likely to be involved, including sympathetic overactivity, selective activation of inflammatory molecular pathways, endothelial dysfunction, abnormality in the process of coagulation, and metabolic dysregulation. The latter may involve insulin resistance and disorders of lipid metabolism. The aim of this review, which reports the data presented at a workshop jointly endorsed by the European Society of Hypertension and by the European Union COST action on OSAS (COST B26), is to critically summarize the evidence available to support an independent association between OSAS and cardiovascular disease. 相似文献
83.
Alexander B Coppola G Perrault SD Peura TT Betts DH King WA 《Molecular reproduction and development》2007,74(12):1525-1537
This study was carried out to determine the telomere length status of sheep clones and their offspring, and to examine telomere dynamics and chromosomal abnormalities in culture propagated donor cells. Skin samples were collected from somatic cell nuclear transfer-derived sheep clones, and three of their progeny generated by natural mating. Samples were collected from control animals (n = 35), spanning in age from 1 month to 36 months of age. Genomic DNA was extracted from cell/tissue samples and their telomere lengths were assessed by terminal restriction fragment (TRF) analysis. Results revealed: that (a) sheep clones derived from cultured somatic cells have shortened telomere lengths compared to age-matched controls; (b) the offspring derived from natural mating between clones had normal telomere lengths compared to their age-matched counterparts; and donor cell cultures beyond 20 population doublings had significantly (P < 0.05) shortened telomeres and exhibited a higher numerical and structural chromosomal abnormalities. 相似文献
84.
Slc7a7 disruption causes fetal growth retardation by downregulating Igf1 in the mouse model of lysinuric protein intolerance 总被引:4,自引:0,他引:4
85.
86.
Demorrow S Francis H Alpini G 《Experimental biology and medicine (Maywood, N.J.)》2007,232(8):1005-1013
Biogenic amines, such as serotonin, histamine, dopamine, and the catecholamines epinephrine and norepinephrine, regulate a multitude of cellular responses. A great deal of effort has been invested into understanding the effects of these molecules and their corresponding receptor systems on cholangiocyte secretion, apoptosis, and growth. This review summarizes the results of these efforts and highlights the importance of these regulatory molecules on the physiology and pathophysiology of cholangiocytes. 相似文献
87.
The Increase in Maternal Expression of axin1 and axin2 Contribute to the Zebrafish Mutant Ichabod Ventralized Phenotype
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Fabio Valenti Jessica Ibetti Yuko Komiya Melissa Baxter Anna Maria Lucchese Lauren Derstine Claudia Covaciu Valeria Rizzo Renza Vento Giuseppe Russo Marcella Macaluso Franco Cotelli Daniele Castiglia Cara J. Gottardi Raymond Habas Antonio Giordano Gianfranco Bellipanni 《Journal of cellular biochemistry》2015,116(3):418-430
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Pharmaceuticals are an important group of emerging pollutants with increasing interest due to their rising consumption and
the evidence for ecotoxicological effects associated to trace amounts in aquatic environments. In this paper, we assessed
the potential degradation of a series of pharmaceuticals: antibiotics (sulfamethoxazole), antidepressives (citalopram hydrobromide
and fluoxetine hydrochloride), antiepileptics (carbamazepine), anti-inflammatory drugs (diclofenac and naproxen) and estrogen
hormones (estrone, 17β-estradiol, 17α-ethinylestradiol) by means of a versatile peroxidase (VP) from the ligninolytic fungus
Bjerkandera adusta. The effects of the reaction conditions: VP activity, organic acid concentration and H2O2 addition rate, on the kinetics of the VP based oxidation system were evaluated. Diclofenac and estrogens were completely
degraded after only 5–25 min even with a very low VP activity (10 U l−1). High degradation percentages (80%) were achieved for sulfamethoxazole and naproxen. Low or undetectable removal yields
were observed for citalopram (up to 18%), fluoxetine (lower than 10%) and carbamazepine (not degraded). 相似文献