全文获取类型
收费全文 | 524篇 |
免费 | 41篇 |
国内免费 | 1篇 |
出版年
2023年 | 7篇 |
2022年 | 26篇 |
2021年 | 29篇 |
2020年 | 41篇 |
2019年 | 61篇 |
2018年 | 47篇 |
2017年 | 19篇 |
2016年 | 21篇 |
2015年 | 28篇 |
2014年 | 21篇 |
2013年 | 34篇 |
2012年 | 44篇 |
2011年 | 23篇 |
2010年 | 17篇 |
2009年 | 20篇 |
2008年 | 15篇 |
2007年 | 28篇 |
2006年 | 12篇 |
2005年 | 21篇 |
2004年 | 12篇 |
2003年 | 9篇 |
2002年 | 4篇 |
2001年 | 9篇 |
2000年 | 2篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1995年 | 1篇 |
1992年 | 2篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1984年 | 1篇 |
排序方式: 共有566条查询结果,搜索用时 31 毫秒
111.
Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members
下载免费PDF全文
![点击此处可从《Molecular and cellular biology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Goetz R Beenken A Ibrahimi OA Kalinina J Olsen SK Eliseenkova AV Xu C Neubert TA Zhang F Linhardt RJ Yu X White KE Inagaki T Kliewer SA Yamamoto M Kurosu H Ogawa Y Kuro-o M Lanske B Razzaque MS Mohammadi M 《Molecular and cellular biology》2007,27(9):3417-3428
Unique among fibroblast growth factors (FGFs), FGF19, -21, and -23 act in an endocrine fashion to regulate energy, bile acid, glucose, lipid, phosphate, and vitamin D homeostasis. These FGFs require the presence of Klotho/betaKlotho in their target tissues. Here, we present the crystal structures of FGF19 alone and FGF23 in complex with sucrose octasulfate, a disaccharide chemically related to heparin. The conformation of the heparin-binding region between beta strands 10 and 12 in FGF19 and FGF23 diverges completely from the common conformation adopted by paracrine-acting FGFs. A cleft between this region and the beta1-beta2 loop, the other heparin-binding region, precludes direct interaction between heparin/heparan sulfate and backbone atoms of FGF19/23. This reduces the heparin-binding affinity of these ligands and confers endocrine function. Klotho/betaKlotho have evolved as a compensatory mechanism for the poor ability of heparin/heparan sulfate to promote binding of FGF19, -21, and -23 to their cognate receptors. 相似文献
112.
113.
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 总被引:3,自引:0,他引:3
Kurosu H Choi M Ogawa Y Dickson AS Goetz R Eliseenkova AV Mohammadi M Rosenblatt KP Kliewer SA Kuro-o M 《The Journal of biological chemistry》2007,282(37):26687-26695
114.
115.
Conspecific populations of plants in their native range are expected to show considerable variation due to long‐term ecological and evolutionary factors. We investigated the levels of secondary metabolites in Heracleum including H. persicum a valuable medicinal plant to depict the magnitude of cryptic variation and the potential significance of novel chemical traits. The essential oil volatiles from fruits of 34 populations from different species of Heracleum in Iranian distribution range and a native of H. sphondylium and an invasive population of H. persicum from Norway were analyzed with GC/MS. Out of 48 compounds identified, a contrasting pattern in the level of two major compounds, octyl acetate and hexyl butyrate was found among all studied species. Interestingly, a significant geographic pattern was observed; the hexyl butyrate/octyl acetate ratio was high (range 1.8 – 3.2) in the northwestern Iranian populations of H. persicum compared to that in northern and central populations (range 0.3 – 0.9). Four populations from Zagros mountains also exhibited a unique composition. Anethole was found in two populations of H. persicum from central Zagros, which has not been previously reported for essential oil of fruits of Heracleum so far. The results suggest high efficiency of large scale sampling from distribution range of species in identifying novel compounds. The unique pattern of geographic structuring also provides novel information to unravel cryptic variation in Heracleum. 相似文献
116.
Ali Movahedi Ming Sang Jiaxin Zhang Kourosh Mohammadi Weibo Sun Amir Almasi Zadeh Yaghuti Saeid Kadkhodaei Honghua Ruan Qiang Zhuge 《Journal of Plant Biology》2018,61(4):227-240
DNA methylation occurs mostly at the C5 position of dinucleotide symmetric CpG sites in genomic DNA. A balance is maintained in the plant genome between DNA methylation mediated by RNA-directed DNA methylation (RdDM) and DNA demethylation mediated by the DEMETER (DME) protein family and REPRESSOR OF SILENCING (ROS1). We used double-stranded RNA (dsRNA) silencing to suppress ROS1 protein expression in ‘Nanlin895’ (Populus deltoides × Populus euramericana ‘Nanlin895’). Leaves of WT and transformant poplars revealed more symmetric methylation on CpG sites than roots and stems. In addition, leaves of transformant poplars revealed more methylated CpG sites in both 5.8S rDNA and histone H3 compared to WT types via 0, 50 and 100 mM NaCl treatments. In asymmetric methylation sites, transformant poplars exhibited more methylated CpHpG and CpHpH contexts than WT poplars. On the other hand, hypermethylation induced by PtROS1-RNAi construct resulted in pleiotropic phenotypic changes in transgenic poplars. The percentage of wavy leaves was increased maximum by ~45% in transgenic poplars. Also, the number of leaves was increased by ~200 number in transformants. Furthermore, shooting (%) and rooting (%) was decreased in transgenic poplars versus WT. 相似文献
117.
Elahe Dadkhodazade Abdorreza Mohammadi Saeedeh Shojaee-Aliabadi Amir Mohammad Mortazavian Leila Mirmoghtadaie Seyede Marzieh Hosseini 《Food biophysics》2018,13(4):404-411
In this study Saccharomyces cerevisiae yeast cells was used as a novel vehicle for encapsulation of vitamin D3. The effects of initial cholecalciferol concentration (100,000 and 500,000 IU/g yeast), yeast cell pretreatment (plasmolysis with NaCl) and drying method (spray or freeze drying) on microcapsules properties were investigated. It was found that the vitamin concentration and drying method had significant influence on encapsulation efficiency (EE) and size of yeast microcapsules. Furthermore, EE values were more increased by the plasmolysis treatment. The highest EE was obtained for plasmolysed and spray dried yeast cells prepared using initial cholecalciferol concentration of 2.5 mg per gram of yeast cells (76.10?±?6.92%). The values of mean particle size were 3.43–7.91 μm. The presence of cholecalciferol in yeast microcapsules was confirmed by X-ray diffraction (XRD) and Fourier transform-infrared (FT-IR) analyses. The in vitro cholecalciferol release from yeast microcapsules in phosphate buffer saline solution (PBS) followed a controlled release manner consistent with a Fickian diffusion mechanism. In addition, the release studies in simulated gastrointestinal tract showed sustained release of cholecalciferol in the stomach condition and significant release in intestinal medium. 相似文献
118.
119.
Vahid Kazemi Moghaddam Mahmood Yousefi Ahmad Khosravi Mehdi Yaseri Amir Hossein Mahvi Mostafa Hadei Ali Akbar Mohammadi Zahrasadat Robati Adel Mokammel 《Biological trace element research》2018,185(2):262-265
The presence of fluoride in drinking water can be either beneficial or harmful for human health, depending on its concentration. Most adverse effects of fluoride are observed at high concentrations (above 1.5 mg/L). This study was aimed to evaluate the effect of fluoride concentrations in drinking water on spontaneous abortion in two regions: one with low fluoride concentration and another with high fluoride concentration. The results showed that there is a relationship between the concentration of fluoride in drinking water and abortion, so that the risk of abortion increased at high concentrations of fluoride. However, further studies are needed to clarify this relationship due to the small area and population in this study. 相似文献
120.
Length–weight relationships of two endemic species of Alburnoides nicolausi (Bogutskaya & Coad, 2009) and Alburnus zagrosensis (Coad, 2009) in Houzian River,Lorestan Province,Iran
下载免费PDF全文
![点击此处可从《Zeitschrift fur angewandte Ichthyologie》网站下载免费的PDF全文](/ch/ext_images/free.gif)
A. Rezamand M. Pouladi A. Qadermarzi R. Ghorbani M. Mohammadi Movahed 《Zeitschrift fur angewandte Ichthyologie》2018,34(3):758-759
This investigation prepares the length–weight relationships (LWRs) of two fish species, including Alburnoides nicolausi (Bogutskaya & Coad, 2009) and Alburnus zagrosensis (Coad, 2009) from Houzian River (latitude 33°22′15.20″ to 33°21′31.57″N; longitude 49°44′39.66″ to 49°44′17.67″E), Lorestan province, Iran. Fish specimens were collected monthly using seine net with 5 mm (Stretched) mesh size between April to September 2017. The LWRs for fish species were W = 0.0059L3.405 (male) and W = 0.0053L3.494 (female) for A. nicolausi, W = 0.0035L3.341 (male) and W = 0.003L3.387 (female) for A. zagrosensis, respectively. The highest value of r2 was .931 for male of A. zagrosensis and lowest value was .964 for male of A. nicolausi. 相似文献