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941.
Sean McCann Onour Moeri Tanya Jones Catherine Scott Grigori Khaskin Regine Gries Sean O'Donnell Gerhard Gries 《PloS one》2013,8(12)
Red-throated Caracaras Ibycter americanus (Falconidae) are specialist predators of social wasps in the Neotropics. It had been proposed that these caracaras possess chemical repellents that allow them to take the brood of wasp nests without being attacked by worker wasps. To determine how caracaras exploit nests of social wasps and whether chemical repellents facilitate predation, we: (1) video recorded the birds attacking wasp nests; (2) analyzed surface extracts of the birds'' faces, feet, and feathers for potential chemical repellents; and (3) inflicted mechanical damage on wasp nests to determine the defensive behavior of wasps in response to varying levels of disturbance. During caracara predation events, two species of large-bodied wasps mounted stinging attacks on caracaras, whereas three smaller-bodied wasp species did not. The “hit-and-run” predation tactic of caracaras when they attacked nests of large and aggressive wasps reduced the risk of getting stung. Our data reveal that the predation strategy of caracaras is based on mechanical disturbance of, and damage to, target wasp nests. Caracara attacks and severe experimental disturbance of nests invariably caused wasps to abscond (abandon their nests). Two compounds in caracara foot extracts [sulcatone and iridodial] elicited electrophysiological responses from wasp antennae, and were also present in defensive secretions of sympatric arboreal-nesting Azteca ants. These compounds appear not to be wasp repellents but to be acquired coincidentally by caracaras when they perch on trees inhabited with Azteca ants. We conclude that caracara predation success does not depend on wasp repellents but relies on the absconding response that is typical of swarm-founding polistine wasps. Our study highlights the potential importance of vertebrate predators in the ecology and evolution of social wasps. 相似文献
942.
Recent developments in lipid mass spectrometry enable extensive lipid class and species analysis in metabolic disorders such as diabesity and metabolic syndrome. The minor plasma lipid class sphingosylphosphorylcholine (SPC) was identified as a ligand for lipid sensitive G-protein coupled receptors playing a key role in cell growth, differentiation, motility, calcium signaling, tissue remodeling, vascular diseases and cancer. However, information about its role in diabesity patients is sparse. In this study, we analyzed plasma lipid species in patients at risk for diabesity and the metabolic syndrome and compared them with healthy controls. Our data show that SPC is significantly increased in plasma samples from metabolic syndrome patients but not in plasma from patients at risk for diabesity. Detailed SPC species analysis showed that the observed increase is due to a significant increase in all detected SPC subspecies. Moreover, a strong positive correlation is observed between total SPC and individual SPC species with both body mass index and the acute phase low grade inflammation marker soluble CD163 (sCD163). Collectively, our study provides new information on SPC plasma levels in metabolic syndrome and suggests new avenues for investigation. 相似文献
943.
Raffaele Teperino Sabine Amann Martina Bayer Sean L. McGeeAndrea Loipetzberger Timothy ConnorCarsten Jaeger Bernd KammererLilli Winter Gerhard WicheKevin Dalgaard Madhan SelvarajMichael Gaster Robert S. Lee-YoungMark A. Febbraio Claude KnaufPatrice D. Cani Fritz AbergerJosef M. Penninger J. Andrew Pospisilik Harald Esterbauer 《Cell》2012,151(2):414-426
944.
Gerhard Hübner 《Journal of Insect Behavior》2000,13(5):771-784
The behavioral interactions between the chemically protected aphid hyperparasitoid Alloxysta brevis and three trophobiotic ant species were examined in the field on thistles. The patterns were not essentially influenced by hyperparasitoid sex. Ants differed in their guarding behavior of aphids and their response toward A. brevis. Lasius niger attacked the hyperparasitoid more readily than Myrmica laevinodis, while aggression by Formica rufa was intermediate. Apart from applying chemical defense, A. brevis responded to ants by flying away (mainly at L. niger) or with avoidance behavior (mainly at M. laevinodis). Additionally, females might switch their tactics from flight to defense with increasing age. Females left the plant more often after encounters with L. niger or F. rufa than with M. laevinodis. Disturbance by any ant species affected the foraging activities, reducing oviposition success to nearly zero. 相似文献
945.
Our previous assignment of the gene loci HBB, HRAS1, INS, PTH, LDHA, and CAT to owl monkey chromosome 19 of karyotype VI (K-VI) indicated a putative homology of this owl monkey chromosome with the short arm of human chromosome 11 (HSA 11p). To investigate further the extent of shared homology, we localized in the owl monkey complement two genes known to be on HSA 11q. Segregation analysis of ETS1 and THY1 homologous DNA in three karyotypically different panels of rodent x owl monkey somatic cell hybrids provided evidence for the syntenic assignment of these loci to homologous chromosomes of three owl monkey karyotypes, namely, chromosomes 4 (K-VI), 3 (K-II), and 5 (K-V). The results indicate a disruption of syntenic gene loci on the distal portion of HSA 11q from 11p during primate evolution. 相似文献
946.
947.
Ghotas Evindar Sylvie G. Bernier Malcolm J. Kavarana Elisabeth Doyle Jeanine Lorusso Michael S. Kelley Keith Halley Amy Hutchings Albion D. Wright Ashis K. Saha Gerhard Hannig Barry A. Morgan William F. Westlin 《Bioorganic & medicinal chemistry letters》2009,19(2):369-372
In the design of potent and selective sphingosine-1-phosphate receptor agonists, we were able to identify two series of molecules based on phenylamide and phenylimidazole analogs of FTY-720. Several designed molecules in these scaffolds have demonstrated selectivity for S1P receptor subtype 1 versus 3 and excellent in vivo activity in mouse. Two molecules PPI-4621 (4b) and PPI-4691 (10a), demonstrated dose responsive lymphopenia, when administered orally. 相似文献
948.
949.
J Süss K H Vogt K J Stiller A Stelzner J Schmidt 《Acta biologica et medica Germanica》1979,38(1):107-118
A rapid and precise method for the assay of cell-mediated immune response basing on protein synthesis stimulation of mitogen-activated guinea pig lymphocytes is modified in a way that enables the study of virus-immunological problems. When used as a micromethod it has the following advantages over conventional methods: short-term cell culture, need of low quantities of cells and rapid preparation of great numbers of samples for radioactivity measurements. In this study we report the results of comparative experiments on measuring lymphocyte stimulation after addition of PHA and stimulation of sensitized lymphocytes following contact with homologous influenza virus antigen in vitro. The most important reaction parameters are as follows: 5-6 . 10(5) spleen lymphocytes/microculture in microtiter plates, use of Eagles's MEM cell culture medium without leucine, supplemented with HEPES buffer and 10% autologous guinea pig serum; optimum lymphocyte stimulation by addition of 0.5 microliter PHA or 0.1-1.0 microgram virus protein/ml; immuno-stimulation by PHA can be measured in vitro already after 6 h and by influenzavirus antigen already after 24 h. 相似文献
950.