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Glen K. Ward Stephen S. Stewart Gus Dotsikas Gerald B. Price William J. Mackillop 《The Histochemical journal》1992,24(9):685-694
Summary Flow cytometry was used to measure the binding of a panel of ten fluorescein isothiocyanate(FITC)-conjugated lectins to fifteen samples of normal and neoplastic human urothelium. Concurrent measurement of light scattering and fluorescence permitted the quantification of lectin binding to cellular subpopulations defined by their light-scattering properties. In normal urothelium, we previously demonstrated levels of lectin binding to the cellular subpopulations derived from the superficial and intermediate cell layers which were higher than levels which bound to the subpopulation derived from the basal cell layer (Wardet al., 1987). This difference was most marked withMaclura pomifera agglutinin (MPA),Ricinus communis agglutinin (RCA) andUlex europus agglutinin (UEA). We now report a similar correlation between the degree of differentiation of a cellular subpopulation and the level of lectin binding in human transitional cell carcinomas (TCCs). Morphological differentiation in human TCCs is accompanied by alterations in cell-surface carbohydrates which are similar to those which accompany cellular differentiation in the corresponding normal tissue. No systematic difference in lectin binding was observed between the corresponding subpopulations of normal and neoplastic urothelial cells. 相似文献
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David A. Sandham Claire Adcock Kamlesh Bala Lucy Barker Zarin Brown Gerald Dubois David Budd Brian Cox Robin A. Fairhurst Markus Furegati Catherine Leblanc Jodie Manini Rachael Profit John Reilly Rowan Stringer Alfred Schmidt Katharine L. Turner Simon J. Watson Jennifer Willis Gareth Williams Caroline Wilson 《Bioorganic & medicinal chemistry letters》2009,19(16):4794-4798
High throughput screening identified a 7-azaindole-3-acetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a highly selective compound with good functional potency for inhibition of human eosinophil shape change in whole blood and oral bioavailability in the rat. 相似文献
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A recent examination of color vision in the ringtail lemur produced evidence that these prosimians could make color discriminations consistent with a diagnosis of trichromatic color vision. However, it was unclear if this behavior reflected the presence of three classes of cone or whether lemurs might be able to utilize signals from rods in conjunction with those from only two classes of cone. To resolve that issue, spectral sensitivity functions were obtained from ringtail lemurs (Lemur catta) and brown lemurs (Eulemur fulvus) using a noninvasive electrophysiological procedure, electroretinographic flicker photometry. Results from experiments involving chromatic adaptation indicate that these lemurs routinely have only a single class of cone photopigment in the middle to long wavelengths (peak sensitivity of about 545 nm); they also have a short-wavelengthsensitive cone pigment with peak of about 437 nm. The earlier behavioral results are suggested to have resulted from the ability of lemurs to jointly utilize signals from rods and cones. The cone pigment complements of these lemurs differ distinctly from those seen among the anthropoids. © 1993 Wiley-Liss, Inc. 相似文献
956.
Gerald D. Carr 《Brittonia》1971,23(3):280-291
The karyology and taxonomy ofPedicularis parryi A. Gray is discussed, and it is proposed that the species consists of three subspecies: ssp.parryi, ssp.purpurea, and ssp.mogollonica. A key to these taxa, and also a key to the Rocky Mountain species most likely to be confused with them are presented. 相似文献
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