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61.
It has recently been suggested that in the rat, sequence variation in the renin gene or closely linked genes may have the capacity to affect blood pressure and contribute to the pathogenesis of hypertension. To map the chromosomal location of the rat renin gene and to investigate its relationship to the inheritance of increased blood pressure, we studied a panel of rat x mouse somatic cell hybrids and a large set of recombinant inbred (RI) strains derived from spontaneously hypertensive rats (SHR) and normotensive Brown-Norway (BN) rats. We have found that in the rat, the renin gene is located on chromosome 13 and that it belongs to a conserved synteny group located on chromosome 1 in man and mouse. We have also found the median blood pressure of the RI strains that inherited the renin allele of the SHR to be greater than that of the RI strains that inherited the renin allele of the normotensive BN rat. These findings, together with the results of previous studies, suggest that in the rat, sequence variation in the renin gene, or in genes linked to the renin locus on chromosome 13, may have the capacity to affect blood pressure. 相似文献
62.
Human thymosin-beta 4/6-26 gene is part of a multigene family composed of seven members located on seven different chromosomes 总被引:1,自引:0,他引:1
We have isolated a cDNA encoding the human interferon-inducible gene 6-26, by screening a cDNA library with an oligodeoxynucleotide probe. Its sequence was found to be identical to that of the human thymosin-beta 4 cDNA, which encodes a protein present in most cell types, but whose function is not clear at present. By hybridization of the thymosin-beta 4/6-26 cDNA to the DNA of a panel of human-rodent somatic cell hybrids, we found that at least seven genes homologous to this cDNA are present in the human genome. We localized these genes, some of which might be pseudogenes, to seven distinct chromosomes, namely, chromosomes 1, 2, 4, 9, 11, 20, and X. 相似文献
63.
A processed pseudogene of the rat Hsc70 gene, Hsc70-ps1, is described, which still presents the open reading frame of the original gene. The pseudogene does not appear to be expressed. It maps to rat Chromosome (Chr) 2. The intron-carrying Hsc70 gene localizes to Chr 8. Hsc70-specific probes detect a large number of more than 20 cross-hybridizing fragments, which show only limited length polymorphism among various inbred rat strains. 相似文献
64.
Nicole L. Washington Karthik Gangavarapu Mark Zeller Alexandre Bolze Elizabeth T. Cirulli Kelly M. Schiabor Barrett Brendan B. Larsen Catelyn Anderson Simon White Tyler Cassens Sharoni Jacobs Geraint Levan Jason Nguyen Jimmy M. Ramirez Charlotte Rivera-Garcia Efren Sandoval Xueqing Wang David Wong Kristian G. Andersen 《Cell》2021,184(10):2587-2594.e7
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The assignment of three rat genes coding for plasma proteins has been deduced from the analysis of rat x mouse cell hybrids. The transferrin and the third component of complement genes were localized on rat chromosomes 8 and 9 respectively, and the beta-fibrinogen gene on chromosome 2. 相似文献
68.
Two recent studies report changes in human brain responses after exposure to?psilocybin, the active ingredient of hallucinogenic mushrooms. Psilocybin increased sensory cortex responses during emotional recollection, but decreased resting-state blood flow in prefrontal cortex, with potential implications for treating depression. 相似文献
69.
Auxin receptors: a new role for F-box proteins 总被引:15,自引:0,他引:15
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