全文获取类型
收费全文 | 23147篇 |
免费 | 1992篇 |
国内免费 | 58篇 |
出版年
2022年 | 155篇 |
2021年 | 276篇 |
2020年 | 162篇 |
2019年 | 228篇 |
2018年 | 259篇 |
2017年 | 228篇 |
2016年 | 391篇 |
2015年 | 699篇 |
2014年 | 759篇 |
2013年 | 1140篇 |
2012年 | 1255篇 |
2011年 | 1291篇 |
2010年 | 781篇 |
2009年 | 747篇 |
2008年 | 1160篇 |
2007年 | 1188篇 |
2006年 | 1104篇 |
2005年 | 1110篇 |
2004年 | 1039篇 |
2003年 | 1012篇 |
2002年 | 995篇 |
2001年 | 296篇 |
2000年 | 271篇 |
1999年 | 339篇 |
1998年 | 292篇 |
1997年 | 227篇 |
1996年 | 238篇 |
1995年 | 213篇 |
1994年 | 230篇 |
1993年 | 195篇 |
1992年 | 244篇 |
1991年 | 223篇 |
1990年 | 193篇 |
1989年 | 202篇 |
1988年 | 224篇 |
1987年 | 197篇 |
1986年 | 187篇 |
1985年 | 225篇 |
1984年 | 234篇 |
1983年 | 224篇 |
1982年 | 232篇 |
1981年 | 256篇 |
1980年 | 216篇 |
1979年 | 187篇 |
1978年 | 220篇 |
1977年 | 198篇 |
1976年 | 161篇 |
1975年 | 170篇 |
1974年 | 182篇 |
1973年 | 177篇 |
排序方式: 共有10000条查询结果,搜索用时 328 毫秒
31.
Elizabeth M. A. Valleley Christine J. Harrison Yvonne Cook Mark W. J. Ferguson Paul T. Sharpe 《Chromosoma》1994,103(7):502-507
Comparative mapping studies of X-linked genes in mammals have provided insights into the evolution of the X chromosome. Many reptiles including the American alligator, Alligator mississippiensis, do not appear to possess heteromorphic sex chromosomes, and sex is determined by the incubation temperature of the egg during embryonic development. Mapping of homologues of mammalian X-linked genes in reptiles could lead to a greater understanding of the evolution of vertebrate sex chromosomes. One of the genes used in the mammalian mapping studies was ZFX, an X-linked copy of the human ZFY gene which was originally isolated as a candidate for the mammalian testis-determining factor (TDF). ZFX is X-linked in eutherians, but maps to two autosomal locations in marsupials and monotremes, close to other genes associated with the eutherian X. The alligator homologue of the ZFY/ZFX genes, Zfc, has been isolated and described previously. A detailed karyotype of A. mississippiensis is presented, together with chromosomal in situ hybridisation data localising the Zfc gene to chromosome 3. Further chromosomal mapping studies using eutherian X-linked genes may reveal conserved chromosomal regions in the alligator that have become part of the eutherian X chromosome during evolution. 相似文献
32.
33.
34.
35.
36.
37.
38.
T Henry A Ferguson 《Comparative biochemistry and physiology. B, Comparative biochemistry》1986,85(2):491-496
Informative crosses have verified the genetic basis of a polymorphism at the Ldh-1 locus in brown trout and enzyme activity measurements indicate that the previously described polymorphism at this locus is best explained by a null allele. The LDH-1, LDH-2, LDH-3 and LDH-4 homotetrameric isozymes were purified and subjected to enzyme kinetic analysis. While LDH-1 and LDH-2 displayed catalytic equivalence, important kinetic differences were found between the LDH-3 and LDH-4 isozymes. 相似文献
39.
Activation of the sympathetic system by phencyclidine (PCP) should result in catecholamine release from the adrenals. However, adrenalectomy does not reduce PCP-induced hypertension. In an attempt to rectify this inconsistency, the direct effects of PCP on the bovine adrenal medulla were examined. At (3×10?6M), PCP reduced the acetylcholine-(ACh)-induced catecholamine release by 50%. Surprisingly, barium-induced secretion of catecholamines was also reduced by PCP. ACh-induced catecholamine release was not altered by 10?3M 4-aminopyridine (4 AP), the potassium channel blocker. Thus, calcium antagonist actions of PCP and consequent block of catecholamine secretion from adrenal medulla may explain the lack of effect of adrenalectomy on PCP-induced hypertension. Possible contributions of calcium and/or potassium channel blockade to other manifestations of PCP overdosage are discussed. 相似文献
40.
Ferguson E. W.; Bernier L. L.; Banta G. R.; Yu-Yahiro J.; Schoomaker E. B. 《Journal of applied physiology》1987,62(4):1416-1421
Sixty healthy men in three physical fitness categories (sedentary, on no organized fitness program; joggers, running 5-15 miles/wk; and marathoners, running greater than 50 miles/wk) were evaluated for changes in blood clotting and fibrinolytic activity before and after maximum exercise on a treadmill according to the Bruce protocol. The rate of blood clotting, as measured by prothrombin times, partial thromboplastin times and thrombin times, was accelerated by exercise (all P less than 0.005). The ability of euglobulin clots and plasma clots to lyse incorporated 125I-fibrin, termed 125I-euglobulin clot lysis (IEL) and 125I-plasma clot lysis (IPCL), were used as indexes of fibrinolytic activity. Marathoners had greater increases in fibrinolytic activity with exercise (76% compared with 63% for joggers and 55% for sedentary subjects by IEL; 427% compared with 418% for joggers and 309% for sedentary subjects by IPCL; all P less than 0.05). Fibrin degradation products increased with exercise (P less than 0.005 for the total group of 60 subjects). The absolute concentrations of alpha 2-plasmin inhibitor, alpha 2-macroglobulin, and antithrombin III increased with exercise (all P less than 0.005), but when concentrations were corrected for acute shifts of plasma water during exercise, the quantity of these inhibitors actually decreased (all P less than 0.005). The changes in clotting assays with exercise were not significantly correlated with changes in whole blood lactate, blood pyruvate, or rectal temperatures. Fibrinolytic assays before and after exercise correlated poorly to moderately with blood lactates (IEL: r = 0.441 and r = 0.425, respectively; IPCL: r = 0.294 and r = 0.544, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献