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排序方式: 共有1033条查询结果,搜索用时 171 毫秒
991.
Marion Picard Satoru Yonekura Karolina Slowicka Ioanna Petta Conrad Rauber Bertrand Routy Corentin Richard Valerio Iebba Maryam Tidjani Alou Sonia Becharef Pierre Ly Eugenie Pizzato Christian H. K. Lehmann Lukas Amon Christophe Klein Paule Opolon Ivo Gomperts Boneca Jean-Yves Scoazec Antoine Hollebecque David Malka Franois Ghiringhelli Diana Dudziak Geert Berx Lars Vereecke Geert van Loo Guido Kroemer Laurence Zitvogel Maria Paula Roberti 《Cell death and differentiation》2021,28(5):1532
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993.
Bruno Verschuere Geert Crombez Lieselot Smolders Armand De Clercq 《Applied psychophysiology and biofeedback》2009,34(3):237-244
Using physiological measures, concealed information can be validly assessed. Orienting theory has been proposed to account
for concealed information testing. As orienting is characterized by heart rate deceleration, one would expect this type of
heart rate response to concealed information. However, with some exceptions, an initial heart rate acceleration to concealed
information is typically observed. In the present paper, we examine the role of verbalization to explain the mixed pattern
of heart rate changes. Using a within-subjects design, 30 participants were asked to either remain silent or to give an overt
verbal response (“yes”/”no”) to concealed autobiographical and control information. The results indicate that verbalization
accounts for the initial heart rate acceleration. In line with the orienting theory, initial heart rate deceleration is observed
when participants remained silent.
Bruno Verschuere is a postdoctoral fellow of the Scientific Research Foundation (FWO). 相似文献
994.
Johan Verbeeck Christel Faes Thomas Neyens Niel Hens Geert Verbeke Patrick Deboosere Geert Molenberghs 《Biometrics》2023,79(1):417-425
The Corona Virus Disease (COVID-19) pandemic has increased mortality in countries worldwide. To evaluate the impact of the pandemic on mortality, the use of excess mortality rather than reported COVID-19 deaths has been suggested. Excess mortality, however, requires estimation of mortality under nonpandemic conditions. Although many methods exist to forecast mortality, they are either complex to apply, require many sources of information, ignore serial correlation, and/or are influenced by historical excess mortality. We propose a linear mixed model that is easy to apply, requires only historical mortality data, allows for serial correlation, and down-weighs the influence of historical excess mortality. Appropriateness of the linear mixed model is evaluated with fit statistics and forecasting accuracy measures for Belgium and the Netherlands. Unlike the commonly used 5-year weekly average, the linear mixed model is forecasting the year-specific mortality, and as a result improves the estimation of excess mortality for Belgium and the Netherlands. 相似文献
995.
Jegan Iyyathurai Jean-Paul Decuypere Luc Leybaert Catheleyne D’hondt Geert Bultynck 《BMC cell biology》2016,17(Z1):S20
Connexins mediate intercellular communication by assembling into hexameric channel complexes that act as hemichannels and gap junction channels. Most connexins are characterized by a very rapid turn-over in a variety of cell systems. The regulation of connexin turn-over by phosphorylation and ubiquitination events has been well documented. Moreover, different pathways have been implicated in connexin degradation, including proteasomal and lysosomal-based pathways. Only recently, autophagy emerged as an important connexin-degradation pathway for different connexin isoforms. As such, conditions well known to induce autophagy have an immediate impact on the connexin-expression levels. This is not only limited to experimental conditions but also several pathophysiological conditions associated with autophagy (dys)function affect connexin levels and their presence at the cell surface as gap junctions. Finally, connexins are not only substrates of autophagy but also emerge as regulators of the autophagy process. In particular, several connexin isoforms appear to recruit pre-autophagosomal autophagy-related proteins, including Atg16 and PI3K-complex components, to the plasma membrane, thereby limiting their availability and capacity for regulating autophagy. 相似文献
996.
Helias A. Udo de Haes Geert R. de Snoo 《The International Journal of Life Cycle Assessment》1996,1(3):168-170
Environmental certification of companies is a promising tool for steering the economy in a more environmentally sound direction. It can also be put in a chain perspective so that companies which constitute a production-consumption chain will conclude agreements between each other with respect to their environmental performance. A legal basis is formed by the EMS of ISO 14001 and the EMAS directive of the EU. However, apart from procedural aspects, substantive aspects should also be included. The major steering factor consists of the image of a company. This in contrast to product policy, where the major steering factor lies in the purchase behaviour of consumers. The two types of life cycle approaches should complement each other. 相似文献
997.
Ben Scheres Heather McKhann Claudia van den Berg Viola Willemsen Harald Wolkenfelt Geert de Vrieze Peter Weisbeek 《Plant and Soil》1996,187(1):97-105
The cellular organisation of theArabidopsis thaliana root is remarkably regular. A fate map of the primary root and root meristem that predicts the developmental destinies of cells within the embryonic root primordium has been constructed. Nevertheless, laser ablation experiments demonstrate that root meristem cells develop according to position and not according to lineage. Mutational analysis has identified genes required for cell specification in the radial as well as in the apical-basal dimension. The corresponding gene functions appear to be necessary during embryogenesis for the formation of a correctly patterned primary root. H Lambers Section editor 相似文献
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999.
Geert A.A. Nibourg Justin D. Boer Tessa V. van der Hoeven Mariëtte T. Ackermans Thomas M. van Gulik Robert A.F.M. Chamuleau Ruurdtje Hoekstra 《Biotechnology and bioengineering》2012,109(12):3182-3188
Bioartificial livers (BALs) are bioreactors containing liver cells that provide extracorporeal liver support to liver‐failure patients. Theoretically, the plasma perfusion flow rate through a BAL is an important determinant of its functionality. Low flow rates can limit functionality due to limited substrate availability, and high flow rates can induce cell damage. This hypothesis was tested by perfusing the AMC‐BAL loaded with the liver cell line HepaRG at four different medium flow rates (0.3, 1.5, 5, and 10 mL/min). Hepatic functions ammonia elimination, urea production, lactate consumption, and 6β‐hydroxylation of testosterone showed 2–20‐fold higher rates at 5 mL/min compared to 0.3 mL/min, while cell damage remained stable. However, at 10 mL/min cell damage was twofold higher, and maximal hepatic functionality was not changed, except for an increase in lactate elimination. On the other hand, only a low flow rate of 0.3 mL/min allowed for an accurate measurement of the ammonia and lactate mass balance across the bioreactor, which is useful for monitoring the BAL's condition during treatment. These results show that (1) the functionality of a BAL highly depends on the perfusion rate; (2) there is a universal optimal flow rate based on various function and cell damage parameters (5 mL/min for HepaRG‐BAL); and (3) in the current set‐up the mass balance of substrate, metabolite, or cell damage markers between in‐and out‐flow of the bioreactor can only be determined at a suboptimal, low, perfusion rate (0.3 mL/min for HepaRG‐BAL). Biotechnol. Bioeng. 2012; 109: 3182–3188. © 2012 Wiley Periodicals, Inc. 相似文献
1000.