全文获取类型
收费全文 | 2767篇 |
免费 | 225篇 |
国内免费 | 1篇 |
出版年
2022年 | 28篇 |
2021年 | 58篇 |
2020年 | 34篇 |
2019年 | 44篇 |
2018年 | 60篇 |
2017年 | 49篇 |
2016年 | 78篇 |
2015年 | 94篇 |
2014年 | 122篇 |
2013年 | 152篇 |
2012年 | 193篇 |
2011年 | 170篇 |
2010年 | 106篇 |
2009年 | 112篇 |
2008年 | 128篇 |
2007年 | 113篇 |
2006年 | 103篇 |
2005年 | 93篇 |
2004年 | 94篇 |
2003年 | 74篇 |
2002年 | 76篇 |
2001年 | 64篇 |
2000年 | 59篇 |
1999年 | 48篇 |
1998年 | 20篇 |
1997年 | 30篇 |
1996年 | 21篇 |
1993年 | 20篇 |
1992年 | 54篇 |
1991年 | 29篇 |
1990年 | 30篇 |
1989年 | 29篇 |
1988年 | 40篇 |
1987年 | 31篇 |
1986年 | 28篇 |
1985年 | 49篇 |
1984年 | 27篇 |
1983年 | 34篇 |
1982年 | 19篇 |
1981年 | 30篇 |
1980年 | 20篇 |
1979年 | 30篇 |
1978年 | 30篇 |
1977年 | 21篇 |
1976年 | 19篇 |
1975年 | 29篇 |
1974年 | 16篇 |
1973年 | 23篇 |
1972年 | 22篇 |
1971年 | 19篇 |
排序方式: 共有2993条查询结果,搜索用时 484 毫秒
111.
Bandyopadhyay Arindam Garai Saraswati Banerjee Prajna Paramita Bhattacharya Shelley Chattopadhyay Ansuman 《Molecular biology reports》2021,48(3):2497-2505
Molecular Biology Reports - Globally, breast cancer is a serious concern that exhibits a persistent rise in its incidence and related mortality even after significant advancement in the field of... 相似文献
112.
Gayatri Jayaraman Karikalan Sinha Subodh Kumar Roy Pranita Mandal Pranab Kumar 《Plant Molecular Biology Reporter》2021,39(3):520-545
Plant Molecular Biology Reporter - Polyploidization plays an important role in the genesis of cultivated wheat (hexaploid and tetraploid) from its diploid progenitors. Thus, evolution during... 相似文献
113.
Erukainure Ochuko L. Salau Veronica F. Atolani Olubunmi Ravichandran Rahul Banerjee Priyanka Preissner Robert Koorbanally Neil A. Islam Md. Shahidul 《Amino acids》2021,53(7):1135-1151
Amino Acids - The antidiabetic effect of l-leucine has been attributed to its modulatory effect on glucose uptake and lipid metabolism in muscles. However, there is a dearth on its effect on... 相似文献
114.
115.
John A. Kloetzel Anne Aubusson-Fleury Maurice D. Butler Deben Banerjee Matteo Mozzicafreddo 《The Journal of eukaryotic microbiology》2021,68(3):e12850
In the hypotrich ciliate Euplotes, many individual basal bodies are grouped together in tightly packed clusters, forming ventral polykinetids. These groups of basal bodies (which produce compound ciliary organelles such as cirri and oral membranelles) are cross-linked into ordered arrays by scaffold structures known as “basal-body cages.” The major protein comprising Euplotes cages has been previously identified and termed “cagein.” Screening a E. aediculatus cDNA expression library with anti-cagein antisera identified a DNA insert containing most of a putative cagein gene; standard PCR techniques were used to complete the sequence. Probes designed from this gene identified a macronuclear “nanochromosome” of ca. 1.5 kb in Southern blots against whole-cell DNA. The protein derived from this sequence (463 residues) is predicted to be hydrophilic and highly charged; however, the native cage structures are highly resistant to salt/detergent extraction. This insolubility could be explained by the coiled-coil regions predicted to extend over much of the length of the derived cagein polypeptide. One frameshift sequence is found within the gene, as well as a short intron. BLAST searches find many ciliates with evident homologues to cagein within their derived genomic sequences. 相似文献
116.
Hanpeng Liao Yudan Bai Chen Liu Chang Wen Qiue Yang Zhi Chen Samiran Banerjee Shungui Zhou Ville-Petri Friman 《Environmental microbiology》2021,23(12):7483-7496
Composting is widely used to reduce the abundance of antibiotic resistance genes (ARGs) in solid waste. While ARG dynamics have been extensively investigated during composting, the fate and abundance of residual ARGs during the storage remain unexplored. Here, we tested experimentally how ARG and mobile genetic element (MGE) abundances change during compost storage using metagenomics, quantitative PCR and direct culturing. We found that 43.8% of ARGs and 39.9% of MGEs quickly recovered already during the first week of storage. This rebound effect was mainly driven by the regrowth of indigenous, antibiotic-resistant bacteria that survived the composting. Bacterial transmission from the surrounding air had a much smaller effect, being most evident as MGE rebound during the later stages of storage. While hyperthermophilic composting was more efficient at reducing the relative abundance of ARGs and MGEs, relatively greater ARG rebound was observed during the storage of hyperthermophilic compost, exceeding the initial levels of untreated sewage sludge. Our study reveals that residual ARGs and MGEs left in the treated compost can quickly rebound during the storage via airborne introduction and regrowth of surviving bacteria, highlighting the need to develop better storage strategies to prevent the rebound of ARGs and MGEs after composting. 相似文献
117.
Minakshi Mazumdar Arghya Adhikary Samik Chakraborty Shravanti Mukherjee Argha Manna Shilpi Saha Suchismita Mohanty Amrita Dutta Pushpak Bhattacharjee Pallab Ray Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Arun K. Ray Gaurisankar Sa Tanya Das 《Apoptosis : an international journal on programmed cell death》2013,18(5):589-604
Mutations in REarranged during Transfection (RET) receptor tyrosine, followed by the oncogenic activation of RET kinase is responsible for the development of medullary thyroid carcinoma (MTC) that responds poorly to conventional chemotherapy. Targeting RET, therefore, might be useful in tailoring surveillance of MTC patients. Here we showed that theaflavins, the bioactive components of black tea, successfully induced apoptosis in human MTC cell line, TT, by inversely modulating two molecular pathways: (i) stalling PI3K/Akt/Bad pathway that resulted in mitochondrial transmembrane potential (MTP) loss, cytochrome-c release and activation of the executioner caspases-9 and -3, and (ii) upholding p38MAPK/caspase-8/caspase-3 pathway via inhibition of Ras/Raf/ERK. Over-expression of either constitutively active myristoylated-Akt-cDNA (Myr-Akt-cDNA) or dominant-negative-caspase-8-cDNA (Dn-caspase-8-cDNA) partially blocked theaflavin-induced apoptosis, while co-transfection of Myr-Akt-cDNA and Dn-caspase-8-cDNA completely eradicated the effect of theaflavins thereby negating the possibility of existence of other pathways. A search for the upstream signaling revealed that theaflavin-induced disruption of lipid raft caused interference in anchorage of RET in lipid raft that in turn stalled phosphorylation of Ras and PI3Kinase. In such anti-survival cellular micro-environment, pro-apoptotic signals were triggered to culminate into programmed death of MTC cell. These findings not only unveil a hitherto unexplained mechanism underlying theaflavin-induced MTC death, but also validate RET as a promising and potential target for MTC therapy. 相似文献
118.
119.
120.
Priyanka Banerjee Sanghamitra Ghosh Mainak Dutta Elavarasan Subramani Jaydeep Khalpada Sourav RoyChoudhury Baidyanath Chakravarty Koel Chaudhury 《PloS one》2013,8(11)
Poor endometrial perfusion during implantation window is reported to be one of the possible causes of idiopathic recurrent spontaneous miscarriage (IRSM). We have tested the hypothesis that certain angiogenic and vasoactive factors are associated with vascular dysfunction during implantation window in IRSM and, therefore, could play a contributory role in making the endometrium unreceptive in these women. This is a prospective case-controlled study carried out on 66 women with IRSM and age and BMI matched 50 fertile women serving as controls. Endometrial expression of pro-inflammatory (IL-1β, TNF-α, IFN-γ, TGF-β1), anti-inflammatory (IL-4, -10), angiogenesis-associated cytokines (IL-2, -6, -8), angiogenic and vasoactive factors including prostaglandin E2 (PGE2), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), nitric oxide (NO) and adrenomedullin (ADM) were measured during implantation window by ELISA. Subendometrial blood flow (SEBF) was assessed by color Doppler ultrasonography. Multivariate analysis was used to identify the significant factor(s) responsible for vascular dysfunction in IRSM women during window of implantation and further correlated with vascular dysfunction. Endometrial expression of pro-inflammatory cytokines and PGE2 were up-regulated and anti-inflammatory and angiogenesis-associated cytokines down-regulated in IRSM women as compared with controls. Further, the angiogenic and vasoactive factors including VEGF, eNOS, NO and ADM were found to be down-regulated and SEBF grossly affected in these women. Multivariate analysis identified IL-10, followed by VEGF and eNOS as the major factors contributing towards vascular dysfunction in IRSM women. Moreover, these factors strongly correlated with blood flow impairment. This study provides an understanding that IL-10, VEGF and eNOS are the principal key components having a contributory role in endometrial vascular dysfunction in women with IRSM. Down-regulation of these factors is also associated with impaired endometrial perfusion which possibly makes the endometrium unreceptive that may eventually cause early pregnancy loss. 相似文献