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641.
642.
Koury JC de Oliveira Kde J Lopes GC de Oliveira AV Portella ES de Moura EG Donangelo CM 《Biological trace element research》2007,115(1):23-30
This study evaluated levels of plasma zinc, copper, and leptin, body composition, and their relationship in nine elite female
judo athletes under two different training conditions. Body composition and biochemical measurements (hematological indexes,
plasma zinc, plasma copper, and plasma leptin) were analyzed 24 h after intense training and following a 5-d period without
training (no-training). Plasma leptin and plasma zinc increased with no-training. Plasma zinc correlated negatively with percent
fat mass (r=−0.62; r=0.05) and positively with plasma leptin (r=0.83; p=0.002) in the no-training condition Plasma copper did not change during the study and correlated positively with plasma leptin
(r=0.66; p=0.05) and with percent fat mass (r=0.80; p=0.007) after training. Percent fat mass was associated negatively with plasma zinc (r=−0.62; p=0.05) in the no-training condition. Moreover percent fat mass was negatively associated with the Zn/Cu plasma ratio under
both training conditions (r<−0.78, p<0.001). These results are consistent with the possible function of zinc as a lipid-mobilizing factor and of copper
as a limiting factor in energy metabolism. 相似文献
643.
Andr Tavares da Silva Fernandes Silvia Bahadian Moreira Luciane Pinto Gaspar Marisol Simes Ana Carolina dos Reis Albuquerque Cajaraville Renata Carvalho Pereira Mariana Pierre de Barros Gomes Jos Henrique Rezende Linhares Vanessa de Oliveira Santos Renata Tourinho Santos Juliana Fernandes Amorim Tamiris Azamor da Costa Barros Juliana Gil Melgao Andra Marques Vieira da Silva Camilla Bayma Fernandes Luciana Neves Tubaro Jane da Silva Elena Cristina Caride Maria Beatriz Borges Rosane Cuber Guimares Renato Srgio Marchevsky Sheila Maria Barbosa de Lima Ana Paula Dinis Ano Bom Patrícia Cristina da Costa Neves Alcides Pissinatti Marcos da Silva Freire 《Journal of medical primatology》2021,50(1):36-45
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645.
Paolla M. V. Abreu Clicia G. Gaspar David S. Buss José A. Ventura Paulo C. G. Ferreira Patricia M. B. Fernandes 《PloS one》2014,9(7)
MicroRNAs are implicated in the response to biotic stresses. Papaya meleira virus (PMeV) is the causal agent of sticky disease, a commercially important pathology in papaya for which there are currently no resistant varieties. PMeV has a number of unusual features, such as residence in the laticifers of infected plants, and the response of the papaya to PMeV infection is not well understood. The protein levels of 20S proteasome subunits increase during PMeV infection, suggesting that proteolysis could be an important aspect of the plant defense response mechanism. To date, 10,598 plant microRNAs have been identified in the Plant miRNAs Database, but only two, miR162 and miR403, are from papaya. In this study, known plant microRNA sequences were used to search for potential microRNAs in the papaya genome. A total of 462 microRNAs, representing 72 microRNA families, were identified. The expression of 11 microRNAs, whose targets are involved in 20S and 26S proteasomal degradation and in other stress response pathways, was compared by real-time PCR in healthy and infected papaya leaf tissue. We found that the expression of miRNAs involved in proteasomal degradation increased in response to very low levels of PMeV titre and decreased as the viral titre increased. In contrast, miRNAs implicated in the plant response to biotic stress decreased their expression at very low level of PMeV and increased at high PMeV levels. Corroborating with this results, analysed target genes for this miRNAs had their expression modulated in a dependent manner. This study represents a comprehensive identification of conserved miRNAs inpapaya. The data presented here might help to complement the available molecular and genomic tools for the study of papaya. The differential expression of some miRNAs and identifying their target genes will be helpful for understanding the regulation and interaction of PMeV and papaya. 相似文献
646.
Jo?o B. A. Neto Cecília R. da Silva Maria A. S. Neta Rosana S. Campos Janaína T. Siebra Rose A. C. Silva Danielle M. Gaspar Hemerson I. F. Magalh?es Manoel O. de Moraes Marina D. P. Lobo Thalles B. Grangeiro Tatiane S. C. Carvalho Emilay B. T. Diogo Eufranio N. da Silva Júnior Felipe A. R. Rodrigues Bruno C. Cavalcanti Hélio V. N. Júnior 《PloS one》2014,9(5)
In recent decades, the incidence of candidemia in tertiary hospitals worldwide has substantially increased. These infections are a major cause of morbidity and mortality; in addition, they prolong hospital stays and raise the costs associated with treatment. Studies have reported a significant increase in infections by non-albicans Candida species, especially C. tropicalis. The number of antifungal drugs on the market is small in comparison to the number of antibacterial agents available. The limited number of treatment options, coupled with the increasing frequency of cross-resistance, makes it necessary to develop new therapeutic strategies. The objective of this study was to evaluate and compare the antifungal activities of three semisynthetic naphthofuranquinone molecules against fluconazole-resistant Candida spp. strains. These results allowed to us to evaluate the antifungal effects of three naphthofuranquinones on fluconazole-resistant C. tropicalis. The toxicity of these compounds was manifested as increased intracellular ROS, which resulted in membrane damage and changes in cell size/granularity, mitochondrial membrane depolarization, and DNA damage (including oxidation and strand breakage). In conclusion, the tested naphthofuranquinones (compounds 1–3) exhibited in vitro cytotoxicity against fluconazole-resistant Candida spp. strains. 相似文献
647.
In the last 15 years, remarkable progress has been realized in identifying the genes that encode the ion-transporting proteins involved in exocrine gland function, including salivary glands. Among these proteins, Ca2+-dependent K+ channels take part in key functions including membrane potential regulation, fluid movement and K+ secretion in exocrine glands. Two K+ channels have been identified in exocrine salivary glands: (1) a Ca2+-activated K+ channel of intermediate single channel conductance encoded by the KCNN4 gene, and (2) a voltage- and Ca2+-dependent K+ channel of large single channel conductance encoded by the KCNMA1 gene. This review focuses on the physiological roles of Ca2+-dependent K+ channels in exocrine salivary glands. We also discuss interesting recent findings on the regulation of Ca2+-dependent K+ channels by protein–protein interactions that may significantly impact exocrine gland physiology. 相似文献
648.
649.
Canopy insect herbivores in the Azorean Laurisilva forests: key host plant species in a highly generalist insect community 总被引:4,自引:0,他引:4
Srvio P. Ribeiro Paulo A. V. Borges Clara Gaspar Catarina Melo Artur R. M. Serrano Joo Amaral Carlos Aguiar Genage Andr Jos A. Quartau 《Ecography》2005,28(3):315-330
This article explores patterns of insect herbivore distribution in the canopy of the Laurisilva forests on seven islands in the Azores archipelago. To our knowledge, this is one of the first extensive study of this type in tree or shrub canopies of oceanic island ecosystems. One of the most frequently debated characteristics of such ecosystems is the likely prevalence of vague, ill‐defined niches due to taxonomic disharmony, which may have implications for insect‐plant interactions. For instance, an increase in ecological opportunities for generalist species is expected due to the lack of predator groups and reduced selection for chemical defence in host plants. The following two questions were addressed: 1) Are specialists species rare, and insect herbivore species randomly distributed among host plant species in the Azores? 2) Are the variances in insect herbivore species composition, frequency and richness explained by host plants or by regional island effects? We expect a proportional distribution of herbivore species between host plants, influenced by host frequency and distinct island effects; otherwise, deviation from expectation might suggest habitat preference for specific host tree crowns. Canopy beating tray samples were performed on seven islands, comprising 50 transects with 1 to 3 plant species each (10 replicates per species), giving 1320 samples from ten host species trees or shrubs in total. From a total of 129 insect herbivore species, a greater number of herbivore species was found on Juniperus brevifolia (s=65) and Erica azorica (s=53). However, the number of herbivore species per individual tree crown was higher for E. azorica than for any other host, on all islands, despite the fact that it was only the fourth more abundant plant. In addition, higher insect species richness and greater insect abundance were found on the trees of Santa Maria Island, the oldest in the archipelago. Insect species composition was strongly influenced by the presence of E. azorica, which was the only host plant with a characteristic fauna across the archipelago, whereas the fauna of other plant crowns was grouped by islands. The great insect occurrence on E. azorica reflects strong habitat fidelity, but only four species were clearly specialists. Our findings indicate a broadly generalist fauna. The simplicity of Azorean Laurisilva contributed to the understanding of insect‐plant mechanisms in canopy forest habitats. 相似文献
650.