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Nair Remya R. Corrochano Silvia Gasco Samanta Tibbit Charlotte Thompson David Maduro Cheryl Ali Zeinab Fratta Pietro Arozena Abraham Acevedo Cunningham Thomas J. Fisher Elizabeth M. C. 《Mammalian genome》2019,30(7-8):173-191
Mammalian Genome - Neurodegenerative disease encompasses a wide range of disorders afflicting the central and peripheral nervous systems and is a major unmet biomedical need of our time. There are... 相似文献
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Tamboli Y Lazzarato L Marini E Guglielmo S Novelli M Beffy P Masiello P Fruttero R Gasco A 《Bioorganic & medicinal chemistry letters》2012,22(11):3810-3815
We describe a new class of NO-donor hypoglycemic products obtained by joining tolbutamide, a typical hypoglycemic sulfonylurea, with a NO-donor moiety through a hard link. As NO-donors we chose either furoxan (1,2,5-oxadiazole 2-oxide) derivatives or the classical nitrooxy function. A preliminary biological characterization of these compounds, including stimulation of insulin release from cultured rat pancreatic β-cells and in vitro vasodilator and anti-aggregatory activities, is reported. 相似文献
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Valentina Candian Carlotta Savio Marco Meneguz Laura Gasco Rosemarie Tedeschi 《Insect Science》2023,30(4):933-946
Insect proteins have been proposed for human and animal food production. Safeguarding the health status of insects in mass rearing allows to obtain high-quality products and to avoid severe economic losses due to entomopathogens. Therefore, new strategies for preserving insect health must be implemented. Modulation of the insect immune system through the diet is one such strategy. We evaluated gene expression of two antimicrobial peptides (one defensin and one cecropin) in Hermetia illucens (L.) (Diptera: Stratiomyidae) reared on different diets. Analyses were performed on prepupae and 10-day-old larvae reared on cereal- and municipal organic waste-based diets and on only prepupae reared on a cereal-based diet supplemented with sunflower, corn, or soybean oil. The inclusion of sunflower oil at different points in the cereal-based diet was also evaluated. Moreover, diet-driven differences in the inhibitory activity of the hemolymph were tested against Escherichia coli DH5α and Micrococcus yunnanensis HI55 using diffusion assays in solid media. Results showed that a municipal organic waste-based diet produced a significant overexpression of antimicrobial peptides only in prepupae. Inclusion of vegetable oils caused an upregulation of at least one peptide, except for the corn oil. Higher expression of both genes was observed when sunflower oil was added 5 days before pupation. All hemolymph samples showed an inhibitory activity against bacteria colonies. Our results suggest that municipal organic waste-based diet and vegetable oil-added diet may successfully impact the immune system of H. illucens. Such alternatives may also exist for other species of economic interest. 相似文献
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Gustavo?F?GonzalesEmail author Sara?Miranda Jessica?Nieto Gilma?Fernández Sandra?Yucra Julio?Rubio Pedro?Yi Manuel?Gasco 《Reproductive biology and endocrinology : RB&E》2005,3(1):5
Background
Epidemiological studies have found that consumption of cruciferous vegetables is associated with a reduced risk of prostate cancer. This effect seems to be due to aromatic glucosinolate content. Glucosinolates are known for have both antiproliferative and proapoptotic actions. 相似文献16.
Konstantin Chegaev Chiara Riganti Barbara Rolando Loretta Lazzarato Elena Gazzano Stefano Guglielmo Dario Ghigo Roberta Fruttero Alberto Gasco 《Bioorganic & medicinal chemistry letters》2013,23(19):5307-5310
Doxorubicin-antioxidant multitarget compounds 6 and 7 were obtained by combining doxorubicin (DOX) with caffeic and ferulic acids through an ester linkage at C-14. The products were studied in in vitro models of cardiomyocytes and breast cancer cells, characterized by different degrees of resistance to DOX, due to different expressions of ATP binding cassette (ABC) transporters. Compound 7 was found to be less toxic than DOX in cardiomyocytes and to display the same possibly higher toxicity against the resistant breast cancer cells. This result shows that appropriate DOX-antioxidant co-drugs can limit the onset of cardiac damage, a significant side-effect of DOX, without impairing the antitumor activity of the parent antibiotic. 相似文献
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Lazzarato L Cena C Rolando B Marini E Lolli ML Guglielmo S Guaita E Morini G Coruzzi G Fruttero R Gasco A 《Bioorganic & medicinal chemistry》2011,19(19):5852-5860
A new group of derivatives of salicylic acid containing NO-donor furoxans, and the related des-NO-furazans, were synthesized and evaluated as new aspirin-like molecules. Their stability was assessed in acid (pH 1) and physiological solutions (pH 7.4), and in human serum. No compound exhibited COX-inhibitory activity against COX-1 and COX-2 isoforms, when tested up to 100μM, respectively, on isolated platelets and on monocytes. Phenylsulfonyl- and cyano-substituted furoxans inhibited platelet aggregation induced by collagen in human platelet-rich plasma, through a cGMP dependent mechanism. Furoxan derivatives displayed cGMP-dependent vasodilator activities, tested on rat aorta strips precontracted with phenylephrine. All products showed anti-inflammatory activity similar to that of ASA, tested on rats by the carrageenan-induced paw edema assay. Unlike ASA, all products showed markedly reduced gastrotoxicity in a rat lesion model. 相似文献
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Scale of human mobility in the southern Andes (Argentina and Chile): A new framework based on strontium isotopes
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Marco Blangetti Barbara Rolando Konstantin Chegaev Stefano Guglielmo Loretta Lazzarato Mariaconcetta Durante Emanuela Masini Nicoletta Almirante Elena Bastia Francesco Impagnatiello Roberta Fruttero Alberto Gasco 《Bioorganic & medicinal chemistry letters》2017,27(3):479-483
A small series of water-soluble NO-donor furoxans bearing a basic center at the 4-position, having a wide lipophilic-hydrophilic balance range, and endowed with different NO-release capacities, were synthesized and characterized. Selected members were studied for their IOP-lowering activity in the transient ocular hypertensive rabbit model at 1% dose. The most effective IOP-lowering products were compounds 3 and 7, whose activity 60 min after administration was similar to that of Timolol. Notably, 7 was characterized by a long-lasting action. The IOP-lowering activity in this series of products appeared to be modulated by the lipophilic-hydrophilic balance rather than by the NO-donor capacity. 相似文献
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Del Grosso E Boschi D Lazzarato L Cena C Di Stilo A Fruttero R Moro S Gasco A 《化学与生物多样性》2005,2(7):886-900
Several NO donor 3,4-diphenylfuroxan (= 3,4-diphenyl-1,2,5-oxadiazole 2-oxide) derivatives were synthesized and tested for their COX-inhibiting activities. The products were found to be selective COX-2 inhibitors, similar to the structurally related furazans (3,4-diphenyl-1,2,5-oxadiazole), devoid of the NO release property. This behavior was confirmed by a molecular-docking study. The NO-dependent platelet anti-aggregatory and vasodilating activities of the new furoxans 5-7 were studied in vitro. These properties can be modulated by inserting an appropriate spacer between the 4-phenyl group and the furoxan ring, giving rise to new, selective COX-2 furoxan derivatives endowed with anti-aggregatory and vasodilating activities, and with potentially reduced cardiotoxicities. 相似文献