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141.
142.
The association of structurally disordered proteins with a number of diseases has engendered enormous interest and therefore
demands a prediction method that would facilitate their expeditious study at molecular level. The present study describes
the development of a computational method for predicting disordered proteins using sequence and profile compositions as input
features for the training of SVM models. First, we developed the amino acid and dipeptide compositions based SVM modules which
yielded sensitivities of 75.6 and 73.2% along with Matthew’s Correlation Coefficient (MCC) values of 0.75 and 0.60, respectively.
In addition, the use of predicted secondary structure content (coil, sheet and helices) in the form of composition values
attained a sensitivity of 76.8% and MCC value of 0.77. Finally, the training of SVM models using evolutionary information
hidden in the multiple sequence alignment profile improved the prediction performance by achieving a sensitivity value of
78% and MCC of 0.78. Furthermore, when evaluated on an independent dataset of partially disordered proteins, the same SVM
module provided a correct prediction rate of 86.6%. Based on the above study, a web server (“DPROT”) was developed for the
prediction of disordered proteins, which is available at . 相似文献
143.
Isolation, identification and application of novel bacterial consortium TJ-1 for the decolourization of structurally different azo dyes 总被引:2,自引:0,他引:2
A novel bacterial consortium (TJ-1), which could decolorize Acid Orange 7 (AO7) and manyother azo dyes, was developed. In TJ-1 three bacterial strains were identified as Aeromonas caviae, Proteus mirabilis and Rhodococcus globerulus by 16S rRNA gene sequence analysis. AO7 decolorization was significantly higher with the use of consortium as compared to the use of individual strains, indicating complementary interactions among these strains. AO7 decolorization was observed under microaerophilic condition in the presence of organic carbon source. Either yeast extract (YE) alone or a combination of YE and glucose resulted in much higher decolorization of AO7 as compared to glucose alone, peptone or starch. Kinetic studies with different initial AO7 concentrations showed that more than 90% decolorization could be achieved even at 200mg/l within 16h. Fed-batch studies showed that AO7 decolorization required 10h during the first cycle and 5h in the second and third cycles, showing that bacterial cells could be used for multiple cycles. The consortium also decolorized fifteen other azo dyes individually as well as a simulated wastewater containing a mixture of all the sixteen azo dyes, thus, conferring the possibility of application of TJ-1 for the treatment of industrial wastewaters. 相似文献
144.
Influence of Water Stress on Water Relations, Photosynthetic Parameters and Nitrogen Metabolism of Moth Bean Genotypes 总被引:1,自引:0,他引:1
Effects of water stress at pre-flowering stage were studied in three genotypes (RMO-40, Maru moth and CZM-32 E) of moth bean [Vigna aconitifolia (Jacq.) Marechal]. Increasing water stress progressively decreased plant water potential, leaf area, net photosynthetic rate, starch and soluble protein contents and nitrate reductase activity while contents of reducing sugars, total soluble sugar, free amino acids and free proline progressively increased. Significant genotypic differences were observed and genotype CZM-32-E displayed a better drought tolerance than other genotypes. 相似文献
145.
We have found in this report, and an earlier one, that in a variety of instances an inverted parabolic relationship between biological activity and CMR or logP is observed. That is, activity first decreases as CMR or logP increases and then turns about and increases. This could be attributed to the ligands causing a change in the receptor structure. The present report considers QSAR for a variety of resistant and sensitive cancer cells. 相似文献
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147.
Y.S. Chauhan V.S. Rathore G.K. Garg Aruna Bhargava 《Biochemical and biophysical research communications》1978,83(4):1237-1245
An enzyme activity which brings about a rapid indole disappearance has been detected in cell free extracts of maize ( L.) leaves. The indole utilization by this enzyme system is not dependent on L-serine and pyridoxal phosphate. It does not result in incorporation of (5-3H) indole or (1-14C) serine into tryptophan. There was no net tryptophan synthesis concomittant with indole disappearance. The enzyme activity is strongly inhibited by dithionite and diethyl-dithiocarbamate. The inhibition by the latter could be specifically removed by Cu2+. The activity of dialyzed enzyme could be restored by addition of Cu2+ and FAD. The products of indole oxidation were characterized as anthranilic acid and anthranil (2,1-benzisooxazole). The activity of the indole oxidizing system was 2 to 3 times higher in normal maize varieties (Ganga-2 and Ganga-5) than in Opaque-2. 相似文献
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