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101.
Cruz-Jentoft AJ Triana FC Gómez-Cabrera MC López-Soto A Masanés F Martín PM Rexach JA Hidalgo DR Salvà A Viña J Formiga F 《Revista espa?ola de geriatría y gerontología》2011,46(2):100-110
Sarcopenia is a common and prominent geriatric syndrome, of major interest for daily clinical practice of professionals working with older people. The number of affected individuals and its relation with disability, frailty, many chronic diseases, lifestyle and adverse outcomes are extremely relevant for geriatric care. Moreover, biological changes that lead to the loss of muscle mass and strength are intrinsically related to the mechanisms of aging. It is not therefore surprising that research in this field is growing exponentially in recent years, and sarcopenia has been placed in recent years in the forefront of research in geriatric medicine and gerontology. The Spanish Society of Geriatrics and Gerontology has recently created an Observatory of Sarcopenia, which aims to promote educational and research activities in this field. The first activity of the Observatory has been to offer the Spanish speaking scientific community a review of the current status of sarcopenia, that may allow unifying concepts and fostering interest in this promising field of geriatrics. 相似文献
102.
Alfonso J. Cruz-JentoftFederico Cuesta Triana Mari Carmen Gómez-CabreraAlfonso López-Soto Ferran MasanésPilar Matía Martín José Antonio Serra RexachDomingo Ruiz Hidalgo Antoni SalvàJosé Viña Francesc Formiga 《Revista espa?ola de geriatría y gerontología》2011,46(2):100
Sarcopenia is a common and prominent geriatric syndrome, of major interest for daily clinical practice of professionals working with older people. The number of affected individuals and its relation with disability, frailty, many chronic diseases, lifestyle and adverse outcomes are extremely relevant for geriatric care. Moreover, biological changes that lead to the loss of muscle mass and strength are intrinsically related to the mechanisms of aging. It is not therefore surprising that research in this field is growing exponentially in recent years, and sarcopenia has been placed in recent years in the forefront of research in geriatric medicine and gerontology.The Spanish Society of Geriatrics and Gerontology has recently created an Observatory of Sarcopenia, which aims to promote educational and research activities in this field. The first activity of the Observatory has been to offer the Spanish speaking scientific community a review of the current status of sarcopenia, that may allow unifying concepts and fostering interest in this promising field of geriatrics. 相似文献
103.
104.
We report the presence of pigmented skin tumors in three populations of the endangered amphibian Montseny brook newt, Calotriton arnoldi, one of the European amphibian species with the smallest distribution range (40 km(2) in the Montseny Natural Park, Catalonia, Spain). Examination of one of the tumors by light microscopy was consistent with chromatophoroma and was most suggestive of a melanophoroma. Tumors were not found in juveniles. In adults, only two of three populations were affected. The proportions of males and females affected were not significantly different, but there was a positive correlation between body size and presence of tumors in both sexes. The etiology of chromatophoromas remains unknown but, in our study, they do not appear to have been caused by water quality or Ultraviolet B. 相似文献
105.
Nursing biocrusts: isolation,cultivation, and fitness test of indigenous cyanobacteria 总被引:2,自引:0,他引:2
Ana Giraldo‐Silva Corey Nelson Nichole N. Barger Ferran Garcia‐Pichel 《Restoration Ecology》2019,27(4):793-803
Biological soil crusts (biocrust) are microbial communities that develop at the soil surface of drylands and play an important role in erosion control and fertility. Soil surface disturbance from a broad range of natural and human processes (e.g. fire, livestock grazing, off‐road traffic) cause significant losses in biocrust cover and associated ecosystems services. Hence, biocrust restoration is emerging as an important intervention strategy to rehabilitate degraded dryland soils. In a multistep process, we designed protocols for the establishment of “microbial nurseries” to produce photosynthetic cyanobacterial inoculum for biocrust seeding at scale. We first report on the strategy for isolation, directly from the target site, of a large culture collection of cyanobacteria that included multiple representatives of the five most common biocrust taxa. After genetic pedigreeing of these isolates, we could select those that best matched field populations genetically for scale‐up cultivation. We then developed protocols for effective cyanobacterial biomass production to obtain sufficient inoculum. This was followed by conditioning treatments (hardening off) to preacclimate this inoculum to the stressful conditions expected in the field. Finally, we show that the inoculum obtained was fit to thrive in its original soil under natural outdoor conditions if sufficient water was available. We repeated this process successfully for four sites, two in the hot Chihuanuan desert and two in the cooler Great Basin Desert, and on two textural types of soils in each. The cyanobacterial biocrust nursery approach represents a versatile, viable, and safe tool for the rehabilitation of dryland soils. 相似文献
106.
Delphine Lapaillerie Benoît Lelandais Eric Mauro Floriane Lagadec Camille Tumiotto Csaba Miskey Guillaume Ferran Natacha Kuschner Christina Calmels Mathieu Mtifiot Caroline Rooryck Zoltan Ivics Marc Ruff Christophe Zimmer Paul Lesbats Jrme Toutain Vincent Parissi 《Nucleic acids research》2021,49(19):11241
The stable insertion of the retroviral genome into the host chromosomes requires the association between integration complexes and cellular chromatin via the interaction between retroviral integrase and the nucleosomal target DNA. This final association may involve the chromatin-binding properties of both the retroviral integrase and its cellular cofactor LEDGF/p75. To investigate this and better understand the LEDGF/p75-mediated chromatin tethering of HIV-1 integrase, we used a combination of biochemical and chromosome-binding assays. Our study revealed that retroviral integrase has an intrinsic ability to bind and recognize specific chromatin regions in metaphase even in the absence of its cofactor. Furthermore, this integrase chromatin-binding property was modulated by the interaction with its cofactor LEDGF/p75, which redirected the enzyme to alternative chromosome regions. We also better determined the chromatin features recognized by each partner alone or within the functional intasome, as well as the chronology of efficient LEDGF/p75-mediated targeting of HIV-1 integrase to chromatin. Our data support a new chromatin-binding function of integrase acting in concert with LEDGF/p75 for the optimal association with the nucleosomal substrate. This work also provides additional information about the behavior of retroviral integration complexes in metaphase chromatin and the mechanism of action of LEDGF/p75 in this specific context. 相似文献
107.
108.
Ferran Sayol Oriol Lapiedra Simon Ducatez Daniel Sol 《Evolution; international journal of organic evolution》2019,73(10):2085-2093
Evidence is accumulating that species traits can spur their evolutionary diversification by influencing niche shifts, range expansions, and extinction risk. Previous work has shown that larger brains (relative to body size) facilitate niche shifts and range expansions by enhancing behavioral plasticity but whether larger brains also promote evolutionary diversification is currently backed by insufficient evidence. We addressed this gap by combining a brain size dataset for >1900 avian species worldwide with estimates of diversification rates based on two conceptually different phylogenetic‐based approaches. We found consistent evidence that lineages with larger brains (relative to body size) have diversified faster than lineages with relatively smaller brains. The best supported trait‐dependent model suggests that brain size primarily affects diversification rates by increasing speciation rather than decreasing extinction rates. In addition, we found that the effect of relatively brain size on species‐level diversification rate is additive to the effect of other intrinsic and extrinsic factors. Altogether, our results highlight the importance of brain size as an important factor in evolution and reinforce the view that intrinsic features of species have the potential to influence the pace of evolution. 相似文献
109.
Ferran Garcia-Pichel Michael Kühl Ulrich Nübel Gerard Muyzer 《Journal of phycology》1999,35(2):227-238
We used benthic flux chambers and microsensor profiling under standardized incubation conditions to compare the short-term (hours) and long-term (days) functional responses to salinity in eight different hypersaline microbial mats. The short-term response of productivity to changes in salinity was specific for each community and in accordance with optimal performance at the respective salinity of origin. This pattern was lost after long-term exposure to varying salinities when responses to salinity were found to approach a general pattern of decreasing photosynthesis and oxygen exchange capacity with increasing salinity. Exhaustive measurements of oxygen export in the light, oxygen consumption in the dark and gross photosynthesis indicated that a salinity-dependent limitation of all three parameters occurred. Maximal values for all three parameters decreased exponentially with increasing salinity; exponential decay rates (base 10) were around 4–5 mL·g−1 . The values of mats in steady state with respect to salinity tended to approach this salinity-dependent limit. On the basis of environmental and ecophysiological data, we argue that this limitation was not caused directly by salinity effects on the microorganisms. Rather, the decreasing diffusive supply of O2 in the dark and the increasing diffusion barriers to O2 escape in the light, which intensify with increasing salinity, were likely responsible for the salinity-dependent limitations observed. 相似文献
110.