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101.
R P Gildersleeve J P Thaxton C R Parkhurst T R Scott M J Galvin D I McRee 《Comparative biochemistry and physiology. A, Comparative physiology》1987,87(2):375-380
1. Coturnix coturnix japonica eggs were exposed to 2.45-GHz continuous wave microwave radiation at an incident power density of 5 mW/cm2 (SAR = 4 mW/g) during the first 12 days of embryogeny. After hatching, leukocyte differential changes were measured in response to an injection with Alectoris graeca chukar red blood cells (CRBC) and in response to a phytohemagglutinin (PHA) injection in irradiated and nonirradiated (sham) quail of both sexes. 2. Microwave irradiation did not affect anti-CRBC hemagglutinin titers, PHA-evoked dermal swelling or leukocyte numbers and percentages. 3. In both the irradiated and sham irradiated males, lymphocyte percentages decreased while heterophil percentages increased after CRBC or PHA injection. 4. In ovo irradiation with microwaves did not alter the time course of either a humoral immune response or a cell-mediated immune response in Japanese quail. 相似文献
102.
Background
Stroke is a leading cause of disability among adults worldwide. Evidence suggests that increased duration of exercise therapy following stroke has a positive impact on functional outcome following stroke. The main objective of this randomised controlled trial is to evaluate the impact of additional family assisted exercise therapy in people with acute stroke. 相似文献103.
Watson RJ Allen DR Birch HL Chapman GA Galvin FC Jopling LA Knight RL Meier D Oliver K Meissner JW Owen DA Thomas EJ Tremayne N Williams SC 《Bioorganic & medicinal chemistry letters》2008,18(1):147-151
The optimization of a series of 1-aryl-3-piperidinyl urea derivatives is described in which incorporation of tropenyl and homotropenyl moieties has led to significant improvements in activity and drug-like properties. Replacement of the central piperidine with an exo-tropanyl unit led to the identification of compound 15 which provides a combination of excellent potency against human and murine receptors, drug-like properties and pharmacokinetics, thus providing a valuable tool for the evaluation of CXCR3 antagonists in models of human disease. 相似文献
104.
Knight RL Allen DR Birch HL Chapman GA Galvin FC Jopling LA Lock CJ Meissner JW Owen DA Raphy G Watson RJ Williams SC 《Bioorganic & medicinal chemistry letters》2008,18(2):629-633
The synthesis and biological evaluation of a novel series of 2-aminoquinoline substituted piperidines and tropanes incorporating a homotropene moiety is herein described. The series exhibits potent antagonism of the CXCR3 receptor and superior physicochemical properties. Compound 24d was found to be orally bioavailable, and PK/PD studies suggested it as a suitable tool for studying the role of CXCR3 in models of disease. 相似文献
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Complete genome sequence of the oral pathogenic Bacterium porphyromonas gingivalis strain W83 总被引:7,自引:0,他引:7
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Nelson KE Fleischmann RD DeBoy RT Paulsen IT Fouts DE Eisen JA Daugherty SC Dodson RJ Durkin AS Gwinn M Haft DH Kolonay JF Nelson WC Mason T Tallon L Gray J Granger D Tettelin H Dong H Galvin JL Duncan MJ Dewhirst FE Fraser CM 《Journal of bacteriology》2003,185(18):5591-5601
The complete 2,343,479-bp genome sequence of the gram-negative, pathogenic oral bacterium Porphyromonas gingivalis strain W83, a major contributor to periodontal disease, was determined. Whole-genome comparative analysis with other available complete genome sequences confirms the close relationship between the Cytophaga-Flavobacteria-Bacteroides (CFB) phylum and the green-sulfur bacteria. Within the CFB phyla, the genomes most similar to that of P. gingivalis are those of Bacteroides thetaiotaomicron and B. fragilis. Outside of the CFB phyla the most similar genome to P. gingivalis is that of Chlorobium tepidum, supporting the previous phylogenetic studies that indicated that the Chlorobia and CFB phyla are related, albeit distantly. Genome analysis of strain W83 reveals a range of pathways and virulence determinants that relate to the novel biology of this oral pathogen. Among these determinants are at least six putative hemagglutinin-like genes and 36 previously unidentified peptidases. Genome analysis also reveals that P. gingivalis can metabolize a range of amino acids and generate a number of metabolic end products that are toxic to the human host or human gingival tissue and contribute to the development of periodontal disease. 相似文献
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108.
The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function 总被引:17,自引:0,他引:17
Thirunavukkarasu K Halladay DL Miles RR Yang X Galvin RJ Chandrasekhar S Martin TJ Onyia JE 《The Journal of biological chemistry》2000,275(33):25163-25172
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