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61.
A V Bogdanov A G Galashina 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1989,39(6):1070-1078
Impulses series, singled out from multineuronal activity by means of amplitude discriminator, were analyzed by creating crosscorrelation histograms. The authors consider that in studying of net brain activity with crosscorrelation method of analysis "window" discrimination of impulses series in multineuronal record is a quite correct method and may be used along with discrimination of spikes by form. It is shown that the size of the "window", used for singling out of separate impulses series, is not a determining parameter in search of temporal dependence in the activity of the investigated cells, as final discrimination of the impulses of dependently acting neuronal pairs occurs at the level of the crosscorrelation method itself. The step of the analysis under the use of crosscorrelation method is of decisive significance for revealing of direct interconnections between neurones in the cases when these connections are masked on histograms with wide peaks reflecting the influences of common sources, on the recorded cells. 相似文献
62.
IL-7 is known foremost for its immunostimulatory capacities, including potent T cell-dependent catabolic effects on bone. In joint diseases like rheumatoid arthritis and osteoarthritis, IL-7, via immune activation, can induce joint destruction. Now it has been demonstrated that increased IL-7 levels are produced by human articular chondrocytes of older individuals and osteoarthritis patients. IL-7 stimulates production of proteases by IL-7 receptor-expressing chondrocytes and enhances cartilage matrix degradation. This indicates that IL-7, indirectly via immune activation, but also by a direct action on cartilage, contributes to joint destruction in rheumatic diseases. 相似文献
63.
Relations between activities of neurons simultaneously recorded in the left and right sensorimotor brain cortices of rabbits were analyzed in a series of experiments before the induction of the immobilization state ("animal hypnosis"), in the state of immobilization, and after its termination. The total baseline percent of significant correlations between activities of neighboring (within 50 microns) neurons in the left hemisphere was significantly lower than in the right hemisphere. This characteristic of the left hemisphere changed neither in the immobilization state nor after its termination. In the right-hemisphere cortex, the total percent of correlations between neighboring neurons significantly decreased during immobilization and returned to the baseline level after the termination of this state. In contrast, percent of correlations between the activities of remote (within 500 microns) neurons in the right-hemisphere did not change during immobilization, whereas in the left cortex it changed significantly and reached its baseline level after the normalization of rabbit's state. Further analysis showed that the revealed cortical interhemispheric asymmetry is underlain by asymmetric activities of individual neurons and small neuronal populations. Thus, for example, changes in the structure of interneuronal correlations in cortical microareas of the left and macroareas of the right hemispheres could be of different directions, whereas correlated activities in microareas of the right and macroareas of the left-hemispheres could change synergetically. In other words, asymmetry was revealed at different levels of neuronal integration (neuronal pairs, micro- or macrogroups of neurons). This finding testifies to a mosaic character of neuronal activity, which finally results in the general functional asymmetry during the "animal hypnosis". Certain changes in the structure of functional relations between neurons of the sensorimotor cortex that developed in the state of "animal hypnosis" persisted and even augmented after the termination of this state. 相似文献
64.
Levshina IP Bogdanov AV Galashina AG Shuĭkin NN 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2004,54(3):420-424
Breathing patterns were recorded during "animal hypnosis" in seven Chinchilla rabbits. The state of "animal hypnosis" was evoked by the hand pressure on the thorax and the waist of a rabbit. Breathing pattern was recorded by means of an elastic coal-powder element that was set round the rabbit's thorax. Distortions of the breathing patterns in the active state and in the course of hypnosis development were marked by numbers 0, 1, 2. In all rabbits, modifications of the breathing patterns depended on the features of the animal state: quiet state, tension, and "animal hypnosis". 相似文献
65.
66.
A nearly universal feature of intron sequences is that even closely related
species exhibit a large number of insertion/deletion differences. The goal
of the analysis described here is to test whether the observed pattern of
insertion/deletion events in the genealogy of the myosin alkali light chain
(Mlc1) gene is consistent with neutrality, and if not, to determine the
underlying forces of evolutionary change. Mlc1 pre-mRNA is alternatively
spliced, and one constraint is that signals necessary for
tissue-specificity of directed splicing must be conserved. If the total
length of an intron is functionally constrained, then the distribution of
indels on branches of the gene genealogy should reflect a departure from
randomness. Here we perform a phylogenetic analysis, inferring ancestral
states wherever possible on a phylogeny of 29 alleles of Mlc1 from six
species of Drosophila. Observed patterns of indels on the genealogy were
compared to those from simulated data, with the result that we cannot
reject the null hypothesis of neutrality. A clear departure from a neutral
prediction was seen in the excess folding free energy predicted for the
introns flanking the alternatively spliced exon. Relative rate tests also
suggest a retardation in the rate of Mlc1 sequence evolution in the
simulans clade.
相似文献
67.
Conservation of alternative splicing and genomic organization of the myosin alkali light-chain (Mlc1) gene among Drosophila species 总被引:3,自引:0,他引:3
The Mlc1 gene of Drosophila melanogaster encodes two MLC1 isoforms via
developmentally regulated alternative pre-mRNA splicing. In larval muscle
and tubular and abdominal muscles of adults, all of the six exons are
included in the spliced mRNA, whereas, in the fibrillar indirect flight
muscle of adult, exon 5 is excluded from the mRNA. We show that this
tissue-specific pattern of alternative splicing of the Mlc1 pre-mRNA is
conserved in D. simulans, D. pseudoobscura, and D. virilis. Isolation and
sequencing of the Mlc1 genes from these three other Drosophila species have
revealed that the overall organization of the genes is identical and that
the genes have maintained a very high level of sequence identity within the
coding region. Pairwise amino acid identities are 94%-99%, and there are no
charge changes among the proteins. Total nucleotide divergence within the
coding region of the four genes supports the accepted genealogy of these
species, but the data indicate a significantly higher rate of amino acid
replacement in the branch leading to D. pseudoobscura. A comparison of
nucleotide substitutions in the coding portions of exon 5 and exon 6, which
encode the alternative carboxyl termini of the two MLC1 isoforms, suggests
that exon 5 is subject to greater evolutionary constraints than is exon 6.
In addition to the coding sequences, there is significant sequence
conservation within the 5' and 3' noncoding DNA and two of the introns,
including one that flanks exon 5. These regions are candidates for cis-
regulatory elements. Our results suggest that evolutionary constraints are
acting on both the coding and noncoding sequences of the Mlc1 gene to
maintain proper expression and function of the two MLC1 polypeptides.
相似文献
68.
69.
The work was conducted on cats with recording multineuronal activity of the motor cortex at the elaboration of conditioned reflex to time. Strength of interaction was estimated between the adjacent and remote neurones in the limits of 0.5 m. The dynamics of strengths of interneuronal interaction in most cases did not correlate with the dynamics of impulses frequency of the studied neurones. Changes of strengths of interaction between mutually remote neurones at CRT were met more frequently than between the adjacent ones, what may serve as one more evidence of the hypothesis on more strict structure of connections within microsystems and greater plasticity of connections between microsystems. 相似文献
70.
Adelmo L Cechin Marialva Sinigaglia Ney Lemke Sérgio Echeverrigaray Odalys G Cabrera Gonçalo AG Pereira José CM Mombach 《BMC plant biology》2008,8(1):50