D-xylo and Lyxofuranonucleosides Reviewed: Some Suggestions on The Mechanism of Activity of Antiviral Nucleosides

Abstract

D-Xylo and Lyxofuranonucleosides have not been extensively studied. Therefore in order to perform a systematic Structure-Antiviral Activity Relationship of the nucleoside analogs we have first synthesized their α and β anomers, some of them being unknown or their structure doubtful in the literature.     

Gas exchange and resource-use patterns along a Mediterranean successional gradient

Abstract. Gas exchange, leaf-nitrogen concentration and water potential were measured in early and late spring in early successional herbaceous plants occurring after cutting and after fire, and in mature woody species from the Mediterranean climax community Quercetum ilicis in central Italy. Net photosynthesis peaked in early spring in all species studied when values for temperature and light were lower but leaf-nitrogen content was higher as compared to late spring, suggesting that nitrogen more than energy input controlled photosynt-hetic rates. Herbaceous pioneer species occurring after cutting showed higher field photo synthetic capacity than evergreen climax trees and shrubs. By contrast, net photosynthesis of herbaceous species occurring in a persistent stage after fire, was in the same range as that of climax trees. This evidence suggests that carbon-gaining appears to be partly related to the dynamic stage of succession and not solely to the growth form.     

Study of the binding of jatrophone to Escherichia coli s-ribonucleic acid

The interaction of jatrophone with sRNA from Escherichia coli has been investigated through UV, CD, and 1H NMR measurements. The results obtained show that the interaction with jatrophone increases the stability of the polynucleotide. It appears that the optical properties of jatrophone depend upon the jatrophone/nucleotide ratio. The observed behaviour can only be explained by the existence of different types of interaction between jatrophone and sRNA. Even for a jatrophone/nucleotide ratio as low as 0.17 the 1H NMR spectra show a multiplicity of resonances that can only be explained by the simultaneous existence of two different binding modes involving the jatrophone molecules.     

Free amino acids from pollens

Pollens from Pinus canariensis, P. nigra, P. pinaster, P. pinea, Castanea sativa, Magnolia grandiflora, Olea sativa cv frantoio, cv itrana, cv pisciottana were examined for their free amino acid composition. A large amount of proline was found in all species; pollens of Olea also contain a large amount of serine.     

Inhibition of cardiolipin synthesis by end-products and other complex lipids in membrane preparations of Micrococcus lysodeikticus.

Using membrane preparations of Micrococcus lysodeikticus, the end-products of cardiolipin synthesis, cardiolipin and glycerol, were shown to inhibit cardiolipin synthetase at several concentrations. Other phospholipids tested for inhibitory effects, phosphatidyl-ethanolamine, phosphatidylinositol, and phosphatidic acid were also shown to inhibit cardiolipin synthesis. Phosphatidic acid was considerably more inhibitory than cardiolipin, phosphatidylethanolamine was similar to cardiolipin, and phosphatidylinositol less inhibitory at the same concentrations. A non-phosphate-containing glycolipid was also inhibitory. In contrast, glycerophosphate had no effect on cardiolipin synthesis.     

Spectroscopic study of monosubstituted amides. II. Rotation isomers in amides substituted by aliphatic side-chain models

The influence of the substituents upon the Amide I and νNH frequencies has been analyzed for ten amides substituted by aliphatic side chains. By considering the aliphatic chain field effect, some data are obtained as to the conformation of the N? C_α bond. In two amides, the presence of an equilibrium between two conformers is shown and a semiquantitative estimation of the energies involved is obtained. The consequences for polypeptides conformation, especially for poly-L -valine, are discussed.     

Influence of environment upon the life history of gudgeon, Gobio gobio (L.): a recent and successful colonizer of the Iberian Peninsula

The growth and the reproductive tactics of gudgeon, Gobio gobio (L.) were assessed in three contrasting streams of the Iberian Peninsula: the Rivers Moros and Ucero, tributaries of the R. Duero, and the R. MatarrańGa, a tributary of the R. Ebro. The R. Duero gudgeon have spread in the last 50 years while their presence in the lower tributaries of the R. Ebro followed the construction of reservoirs in the mid 1960s. The life histories of the Moros and MatarrańnGa gudgeon are very similar; rapid growth in spring, early reproduction (1 -year-old), high reproductive cost, short life-span and trend to semelparity. Both populations are strongly influenced by the severe summer droughts that result in (I) reduction in the condition coefficient, (2) reduction in the growth rate (particularly in the River MatarrańGa), (3) single spawning and (4) no gonad development in the summer. The gudgeon in the Ucero delay maturity, grow slower, are multi-spawners and have a longer life span. All the Duero populations come from the same genetic pool and they are actually connected through the populations living along this river basin, whereas the MatarrańGa population is not genetically linked, we hypothesize that the differences between these populations are environmentally induced.