排序方式: 共有49条查询结果,搜索用时 15 毫秒
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L I Gabain 《Arkhiv anatomii, gistologii i émbriologii》1985,88(3):54-61
The literature concerning the problems of myocyrdial sinusoids has been analysed and morphological investigation of 98 human hearts has been performed. As demonstrates the comparison of the literature data, the term "sinusoid" in the human heart is applied to different structures. In some cases--to designate dilated areas of the venous part of the blood bed in the ventricular walls, in others--"hollow spaces", "intercellular spaces" and Vieussens--Thebesius vessels. Combining methods of intravascular injections and studying serial histological sections, it has been found that the sinusoids--the "hollow spaces", the "intercellular spaces", the "Veussens--Thebesius vessels" present the areas of intertrabcular spaces, which get into the planes of some sections, not being components of the myocardial blood bed. Spatial angioarchitectonics of the sinusoids--dilated areas in the venous part of the myocardial blood bed have been investigated by means of the plastic reconstruction method. It is suggested to apply the term "sinusoids" only to the given parts of the cardiac blood bed. 相似文献
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Genetic studies of cleavage-initiated mRNA decay and processing of ribosomal 9S RNA show that the Escherichia coli ams and rne loci are the same 总被引:12,自引:0,他引:12
We show in the present paper that the cleavages initiating decay of the ompA mRNA are suppressed both in the Escherichia coli ams(ts) strain (originally defined by a prolonged bulk mRNA half-life) and in the me(ts) strain (originally defined by aberrant 9S RNA processing). The temperature-sensitive defects of both these strains are complemented by a recombinant lambda phage containing a genomic segment that carries the putative ams locus. A 5.8 kb fragment from this genomic DNA segment was cloned into a low-copy plasmid and used to transform the ams(ts) and rne(ts) strains. This resulted in growth at the non-permissive temperature and a reoccurrence of the cleavages initiating decay of the ompA mRNA. Deletion analyses of this 5.8 kb fragment indicated that the putative ams open reading frame could complement both the Ams(ts) and the Rne(ts) phenotype with regard to the ompA cleavages. In addition we showed that the ams(ts) strain suppresses 9S RNA processing to 5S RNA to the same extent as the rne(ts) strain, and that the rne(ts0 strain has a prolonged bulk mRNA half-life, as was reported for the ams(ts) strain. Therefore we suggest that ams and rne reflect the same gene locus; one which is involved both in mRNA decay and RNA processing. We discuss how this gene locus may related to the previously characterized endoribonucleolytic activities of RNase E and RNase K. 相似文献
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The EBNA2-related resistance towards alpha interferon (IFN-alpha) in Burkitt''s lymphoma cells effects induction of IFN-induced genes but not the activation of transcription factor ISGF-3. 下载免费PDF全文
K Kanda T Decker P Aman M Wahlstr?m A von Gabain B Kallin 《Molecular and cellular biology》1992,12(11):4930-4936
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Growth Phase-Regulated Induction of Salmonella-Induced Macrophage Apoptosis Correlates with Transient Expression of SPI-1 Genes 下载免费PDF全文
Urban Lundberg Ursula Vinatzer Daniela Berdnik Alexander von Gabain Manuela Baccarini 《Journal of bacteriology》1999,181(11):3433-3437
Invasive Salmonella has been reported to induce apoptosis in a fraction of infected macrophages within 2 to 14 h from the time of infection by a mechanism involving the type III secretion machinery encoded by the Salmonella pathogenicity island 1 (SPI-1). Here, we show that bacteria in the transition from logarithmic to stationary phase cause 90% of the macrophages to undergo phagocytosis-independent, caspase-mediated apoptosis within 30 to 60 min of infection. The ability of Salmonella to induce this rapid apoptosis was growth phase regulated and cell type restricted, with epithelial cells being resistant. Apoptosis induction was also abrogated by disruption of the hilA gene (encoding a regulator of SPI-1 genes) and by the expression of a constitutively active PhoPQ. hilA itself and a subset of SPI-1 genes were transiently expressed during aerobic growth in liquid medium. Interestingly, however, hilA was found to be required only for the expression of the prgH gene, while sipB, invA, and invF were expressed in a hilA-independent manner. The expression of SPI-1 genes and the secretion of invasion-associated proteins correlated temporally with the induction of apoptosis and are likely to represent its molecular basis. Thus, growth phase transition regulates the expression and secretion of virulence determinants and represents the most efficient environmental cue for apoptosis induction reported to date. 相似文献
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