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ABSTRACT. Explaining the low incidence of invasive disease (10%) in humans infected with Entamoeba histolytica has occupied the attention of generations of both clinical and nonclinical investigators. One possible explanation would be the existence of two morphologically identical species—one an invasive pathogen, the other noninvasive. This was first proposed by Brumpt in 1925, but his explanation was virtually ignored until 1978 when the first of several publications appeared suggesting that E. histolytica did indeed consist of two species. We have reexamined Brumpt's claim in light of recent biochemical, immunological and genetic studies and conclude that the data derived from these investigations provide unequivocal evidence supporting his hypothesis. With this in mind, we redescribe the invasive parasite retaining the name Entamoeba histolytica Schaudinn, 1903 (Emended Walker, 1911), and set it apart from the noninvasive parasite described by Brumpt, Entamoeba dispar Brumpt, 1925. 相似文献
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We have examined a variety of invertebrate and vertebrate musclesin the electron microscope and have seen evidence of a third,very thin (25 Ä) filament in all of them. This filamenthas been seen in H zones, A bands, and I bands, as well as bridgingthe gap between actin and myosin filaments in greatly stretchedmuscle. It, thus, seems likely that, if a third filament exists,it is elastic and extends throughout the sarcomere from Z discto Z disc, unlike the hypothetical actin-actin(s) filament ofHanson and Huxley (1955), or the actinmyosin gap filaments ofSjostrand (1962) and Carlsen, et al. (1965). These filaments therefore provide an answer to some of the presentparadoxes of muscle ultrastructure. 相似文献
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MARGARET HESLIN LOUISE HOWARD MORVEN LEESE PAUL McCRONE CHRISTOPHER RICE MANUELA JARRETT TERRY SPOKES PETER HUXLEY GRAHAM THORNICROFT 《World psychiatry》2011,10(2):132-137
Studies from North America have concluded that supported employment using the Individual Placement and Support (IPS) model is effective in helping individuals with severe and persistent mental illness gain competitive employment. The aim of this study was to investigate the effectiveness and cost-effectiveness of IPS in England in patients followed up for 2 years. Patients with severe mental illness were randomised to IPS or local vocational services (treatment as usual). Service use and costs were measured. Two hundred-nineteen participants were randomised, and 86% re-assessed 2 years later. In the multivariate analysis, relatively low rates of competitive employment were found in both the intervention group and the treatment as usual group, although significantly more patients obtained competitive employment in the treatment arm (22% vs. 11%, p=0.041). There were no significant differences in costs. The employment rate among participants receiving IPS was lower than in previously published reports, and the number needed to treat to obtain the benefit of IPS was relatively high. This may reflect difficulties in the implementation of IPS where it is not structurally integrated within mental health teams, as well as economic disincentives which lead to lower levels of motivation for patients and mental health professionals. 相似文献
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Ninety-nine selected compounds and eleven antibiotic-producing organisms were tested for antiphage activity and host toxicity. A paper disc-agar diffusion method was used for primary screening and quantitative methods were employed for confirmatory investigation. Most of the agents tested, although previously reported as inhibitory to one or more other virus-host systems, did not selectively prevent multiplication of lactic streptococcus bacteriophage. Several compounds which prevented mass lysis were extremely toxic to host bacteria. Crystal violet suppressed growth of two phage strains at a level (1.0 x 10(-7)M) which permitted normal growth of the host cells. Failure of crystal violet to prevent multiplication of many phage strains suggested possible variations in the multiplication mechanisms of different strains of virus. Virustatic levels of crystal violet did not destroy unadsorbed virus, reduce adsorption, or prevent invasion; increase of virus was reduced in one-step growth experiments; mass lysis was prevented or delayed in long time experiments. Addition and removal of crystal violet at various intervals during the latent period resulted in virus yields directly related to the portion of the latent period during which no dye was present. Duration of the latent period was unaffected. Single burst experiments indicated that the yield of plaque-forming particles per infected bacterium was reduced; the proportion of infected bacteria giving rise to active progeny did not appear to be influenced to a significant degree. Crystal violet apparently interferes with intracellular multiplication of the virus, possibly by combination of the dye with phage DNA or fractions thereof at some critical stage in the incorporation of DNA into the virus particle. 相似文献
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MARTIN ZUSCHIN P. GRAHAM OLIVER 《Lethaia: An International Journal of Palaeontology and Stratigraphy》2003,36(2):133-149
This study quantified the degree of coincidence between living and dead molluscan faunas in a shallow-water coral reef environment in the Indian Ocean. The results were compared with those from a similar life:death study in the northern Red Sea, and with those published for reef corals and soft substrata molluscs. The proportions of quantitatively important taxa are robust to sampling intensity, but fidelity indices and rank-order correlations are strongly influenced by quantitatively unimportant taxa. Distinct differences between life and death assemblages were recognized, which are due to distinct biases in the death assemblage. Bivalves that lived in close contact with living corals are preferentially overgrown after death and should provide considerable temporal and ecological information in a potential fossil record, as they will be preserved within a rapidly growing reef framework. Some gastropod taxa are preferentially transported into surrounding soft substrata postmortem. Here they will be affected by time-averaging and taphonomic disintegration typically occurring in sediments resulting in the associated loss of much temporal information. Most gastropod shells, however, are inhabited by hermit crabs postmortem, which may strongly alter the fossil gastropod community structure. The results are similar to a comparable study in the northern Red Sea, with a major exception being the strong dominance of hermit crab-inhabited gastropod shells in the death assemblage of the Seychelles. Comparison of life:death assemblages between hard and soft substrata, in keeping with the northern Red Sea study, showed the strong dominance of dead shells in the soft substrata with the converse on the hard substrata. This results from different accumulation conditions for dead shells in soft substrata. Fidelity indices are well suited to demonstrate that sedimentary death assemblages are typically remarkably robust reflections of local community composition but they do not record the strong biases in death assemblages of coral reef associated hard substrata molluscs and are therefore unsuitable for comparisons of life and death assemblages in reef environments. 相似文献