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61.
Shiro Ohki Yoshimasa Nishigaki Katsuhiro Imaki Masayasu Kurono Fumio Hirata Toshio Hanyu Nobuhiko Nakazawa 《Prostaglandins & other lipid mediators》1976,12(2):181-186
Radioimmunoassay technique for measuring 5α,7α-dihydroxy-11-keto-tetranorprosta-1,16-dioic acid, the main urinary metabolite of PGF1α and PGF2α (PGF2α-MUM), was further improved.It was postulated based on some experimental data that the PGF2α-MUM exists in the urine mostly as dioic acid form, not as δ-lactone formThe daily excretion of PGF2α-MUM in men ranged from 14.43 μg to 36.14 μg and in women from 5.21 μg to 14.25 μg. 相似文献
62.
Keishi Abe Yoichi Otsuka Minoru Yasujima Satoru Ciba Masahide Seino Nobuo Irokawa Kaoru Yoshinaga Fumio Hirata Shiro Ohki Nobuhiko Nakazawa Toshio Hanyu 《Prostaglandins & other lipid mediators》1976,12(5):843-848
The excretion rates of main urinary metabolite of PG F2α were measured radioimmunologically in 4 healthy persons and in 13 essential hypertensives. The resting values were 9.3±0.73 in the former and 10.4±2.17 ng/min in the latter. There was no significant differences between them. The excretion of the metabolite decresed prominently after the administration of furosemide. The percent decrease was 57% in healthy persons and 70% in essential hypertension. The percent result supports that furosemide inhibit the catabolism of PG F2α. 相似文献
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Motosugi Nanane Nakamura Futoshi Nakajima Souta Takahata Chihiro Kawamura Kazuhiro Morimoto Junko 《Landscape and Ecological Engineering》2021,17(2):95-106
Landscape and Ecological Engineering - There have been many earlier studies of the biodiversity and ecosystem services of abandoned farmlands, but studies of abandoned villages are limited,... 相似文献
67.
Sakiyama Tomoki Morimoto Junko Matsubayashi Jun Furukawa Yasuto Kondo Mami Tsuruga Hifumi Mano Tsutomu Nakamura Futoshi 《Landscape and Ecological Engineering》2021,17(3):351-362
Landscape and Ecological Engineering - Investigating factors underlying human-wildlife conflicts in agricultural landscapes is important for both preventing crop damage and wildlife conservation.... 相似文献
68.
Hiroe Nakazawa Naoto Fukuyama Shunya Takizawa Chizuko Tsuji Motoyuki Yoshitake Hideyuki Ishida 《Free radical research》2013,47(6):771-784
The formation of peroxynitrite and nitrotyrosine was examined in a variety of in vitro and in vivo animal models and its relation to cell or tissue damage was examined. In polymorphonuclear leukocyte (PMN)-induced injury to cardiac myocytes or endothelial cells, activated PMN produced peroxynitrite. Peroxynitrite appears to be responsible for the injury but it was not a major mediator of endothelial cell injury. In the experiment of ischemia-reperfusion injury of the rat brain nitrotyrosine was formed in the peri-infarct and core-of infarct regions. The degradation curve of nitrotyrosine revealed that its t1/2 was about 2.2 hours. In the radiation-induced lung injury of rats, nitrotyrosine was also formed but it was not the sole mechanism for the injury. Levels of nitrotyrosine correlated with the severity of myocardial dysfunction in the canine model of cytokine-induced cardiac injury. Inhibition of NO generation abolished the formation of peroxynitrite and nitrotyrosine in all experiments. In conclusion; although nitrotyrosine is formed in a variety of pathological conditions where the generation of NO is increased, its presence does not always correlate with the severity of injury. 相似文献
69.
Kohji Ichimori Naoto Fukuyama Hiroe Nakazawa Yasuaki Aratani Hideki Koyama Shunya Takizawa 《Free radical research》2013,47(5):481-489
Myeloperoxidase (MPO) catalyzes a nitration reaction to form nitrotyrosine in the presence of high nitrite, the metabolite of NO. Human leukocyte was shown to cause phenolic nitration using released MPO as a catalyst in the presence of nitrite. It opposes our previous finding that inhibition of MPO was essential for phenol nitration in human leukocyte study. To clarify the role of MPO, we utilized MPO-deficient human leukocytes and MPO-knockout mice. Even in the absence of exogenously added nitrite, high nitration product was observed in MPO-deficient leukocytes. In liver subjected to ischemia/reperfusion injury, a significantly higher amount of nitrotyrosine was produced in MPO-knockout mice than in normal mice. These results clearly demonstrate that MPO inhibits the accumulation of nitration products in vivo . Further experiments showed that MPO could degrade nitrotyrosine in the presence of glutathione. Thus, MPO-induced degradation of nitration products may cause the underestimation of the nitration product generated in vivo . We conclude that MPO may act predominantly to scavenge nitrotyrosine under physiological nitrite condition, and protect against injurious effect of nitrotyrosine. 相似文献
70.
Maki Sugaya Futoshi Nishimura Akira Katoh Kazuo Harada 《Nucleosides, nucleotides & nucleic acids》2013,32(5):534-545
In this study, the ability to tailor the peptide-binding specificity of an RNA was investigated. First, variants of the Rev-response element (RRE) RNA with different specificities toward the natural binding partner, Rev, and two RRE-binding aptamers, the RSG-1.2 and the Kl peptides, were identified. Next, hybrid RRE mutants with combinations of two sets of specificity-altering substitutions were tested for peptide-binding specificity. It was shown that in most cases the results of the combination of individual mutations were of an additive nature, therefore providing a way to manipulate the peptide-binding specificity of an RNA in a predictable manner. 相似文献