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61.
BUdR-sensitive fluorescence of the dye 33258 Hoechst allows microfluorometric analysis of replication in human chromosomes. Comparison of the fluorescence patterns of male and female X chromosomes obtained with this technique reveals differences that may reflect regional alterations in DNA synthesis kinetics. 相似文献
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K Tanaka T Nakagawa T Hazama Y Matsuura K Asano T Iseki 《European journal of applied physiology and occupational physiology》1985,54(4):386-390
The predictability of anaerobic threshold (AT) from maximal aerobic power, distance running performance, chronological age, and total running distance achieved on the treadmill (TRD) was investigated in a sample of 53 male distance runners, 17-23 years of age. The dependent variable was oxygen uptake (Vo2) at which AT was detected (i.e. Vo2 @ AT). A regression analysis of the data indicated Vo2 @ AT could be predicted from the following four measurements with a multiple R = 0.831 and a standard error of the estimate of 2.66 ml . min-1 . kg-1: Vo2max (67.9 +/- 5.7 ml . min-1 . kg-1), 1,500-m running performance (254.5 +/- 14.2 s), TRD (6.82 +/- 1.13 km), and age (19.4 +/- 2.2 years). When independent variables were limited to Vo2max (X1) and 1,500-m running performance (X2) for simpler assessment, a multiple R = 0.806 and a standard error of the estimate of 2.76 ml . min-1 . kg-1 were computed. A useful prediction equation with this predictive accuracy was considered to be Vo2 @ AT = 0.386X1 - 0.128X2 + 57.11. To determine if the prediction equation developed for the 53 male distance runners could be generalized to other samples, cross-validation of the equation was tested, using 21 different distance runners, 17-22 years of age. A high correlation (R = 0.927) was obtained between Vo2 AT predicted from the above equation and directly measured Vo2 @ AT. It is concluded that the generalized equation may be applicable to young distance runners for indirect assessment of Vo2 @ AT. 相似文献
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Akira Sano Noriko Yamauchi Yasuo Kakimoto Osamu Komure Jun Kawai Fumitada Hazama Kazuyo Kuzume Nozomi Sano Ikuko Kondo 《Human genetics》1994,93(6):699-702
Anticipation refers to the progressively earlier onset and increase in disease severity in successive generations. We studied four families with hereditary dentatorubral-pallidoluysian atrophy (DRPLA), a neurodegenerative disease, and anticipation was present in the mode of inheritance. In subsequent generations DRPLA shows an earlier onset and more severe as well as additional symptoms. Older onset patients suffer from cerebellar ataxia with or without dementia, whereas younger onset patients present as progressive myoclonus epilepsy syndrome, which consists of mental retardation, dementia, and cerebellar ataxia as well as epilepsy and myoclonus. Anticipation with paternal transmission was significantly greater than with maternal transmission. 相似文献