全文获取类型
收费全文 | 308篇 |
免费 | 36篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 5篇 |
2020年 | 5篇 |
2019年 | 1篇 |
2018年 | 6篇 |
2017年 | 9篇 |
2016年 | 4篇 |
2015年 | 16篇 |
2014年 | 14篇 |
2013年 | 27篇 |
2012年 | 25篇 |
2011年 | 26篇 |
2010年 | 11篇 |
2009年 | 11篇 |
2008年 | 24篇 |
2007年 | 19篇 |
2006年 | 24篇 |
2005年 | 14篇 |
2004年 | 23篇 |
2003年 | 16篇 |
2002年 | 21篇 |
2001年 | 1篇 |
2000年 | 3篇 |
1999年 | 1篇 |
1998年 | 4篇 |
1997年 | 2篇 |
1996年 | 2篇 |
1995年 | 2篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 1篇 |
1978年 | 2篇 |
1975年 | 1篇 |
1974年 | 1篇 |
1973年 | 2篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1970年 | 1篇 |
排序方式: 共有344条查询结果,搜索用时 171 毫秒
71.
Chemoimmunotherapy with cyclophosphamide and bestatin in experimental metastasis in mice 总被引:1,自引:0,他引:1
Fuminori Abe Mark Schneider Paul L. Black James E. Talmadge 《Cancer immunology, immunotherapy : CII》1989,29(4):231-236
Summary Bestatin has significant therapeutic activity (even following oral administration) for the treatment of metastatic disease, an activity which is limited by tumor burden. Therefore, the therapeutic potential of bestatin was examined in combination with chemotherapy to determine if there is additive activity for heavy tumor burdens. Bestatin significantly increased therapeutic activity and decreased the myelotoxicity of cyclophosphamide following a single injection of cyclophosphamide or split daily doses. In immune function studies, in tumor-bearing antimals, bestatin increased the number of colony-forming units (granulocyte-macrophage) (CFU) and alveolar macrophage tumoricidal activity. However, when bestatin was combined with cyclophosphamide, which depressed bone marrow and macrophage activity, it did not show apparent augmentation of macrophage and NK cell activity, but did significantly increase bone marrow CFU activity. Thus, in combined chemoimmunotherapy, bestatin appears to enhance therapeutic activity by accelerating the recovery of hematopoiesis. We suggest, therefore, that a combination chemotherapy protocol, with oral bestatin, may facilitate myelorestoration following aggressive chemotherapy. The majority of biological response modifiers require parental administration; thus, the identification of an orally active, synthetic immunoaugmenting agent with a defined receptor is of particular interest.This research was sponsored by the National Cancer Institute, DHHS, under contract no. N01-23910 with Program Resources Inc. The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. 相似文献
72.
Fuminori Abe Akira Matsuda Mark Schneider James E. Talmadge 《Cancer immunology, immunotherapy : CII》1990,32(2):75-80
Summary The effect of bestatin on hematopoietic parameters and bone marrow progenitor activity (colony-forming unit — granulocyte/macrophage: CFU-GM) was examined in normal and myelosuppressed C57BL/6 mice. CFU-GM frequency and absolute number were determined with a limiting dilution analysis of bone marrow cells in soft agar using recombinant murine colony-stimulating factor — granulocyte/macrophage. We report that bestatin increased splenic, bone marrow, and peripheral blood cellularity and the number of CFU-GM over a dose range from 2.5 mg/kg through 100 mg/kg following i.p., i.v., or oral administration. The greatest myeloid stimulation was observed following multiple injections of bestatin. Bestatin also increased the recovery from cyclophosphamide-induced myelodepression as measured by these parameters. The hematopoietic properties of bestatin following oral administration is of potential importance for clinical application.By acceptance of this article, the publisher or recipient acknowledges the right of the U. S. Government to retain a nonexclusive, royalty-free license in and to any copyright covering the article. This research was supported by the DHHS, under contract no. N01-23910 with Program Resources Inc. The contents of this publication do not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U. S. Government. 相似文献
73.
74.
Ichiro Azuma Fuminori Kanetsuna Yoshinori Tanaka Yuichi Yamamura Luis M. Carbonell 《Mycopathologia》1974,54(1):111-125
Serologically active polysaccharide, galactomannan, was isolated from whole cells ofH. capsulatum, H. duboisii, P. brasiliensis andB. dermatitidis, and their chemical structure and immunological properties were described. 相似文献
75.
Kenro Tazaki Masako Miyatani Fuminori Ando 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1986,159(4):521-533
Summary The stomatogastric nervous system of a mantis shrimp,Squilla oratoria, is described. The motor nerves of the stomatogastric ganglion (STG) and their innervation of muscles of the posterior cardiac plate (pcp) and pyloric systems are detailed.The STG contains more than 25 neurons. It sends out one pair of major output nerves. The pcp-pyloric cycle recorded from the motor axons in this nerve consists of rhythmic bursts of several units which fire with a characteristic phase relationship to each other. The rhythm is intrinsic to the STG itself, but it is modifiable.Recordings from the peripheral nerves reveal that identifiable cardiac plate, pyloric dilator and pyloric neurons control sequential contractions of the pcp and pyloric muscles to constrict or dilate a number of their attached ossicles.Several modulatory input fibres in the stomatogastric nerve, activated via stimulation of the superior or inferior oesophageal nerve (son, ion), prime or trigger the cyclic motor outputs. The son inputs induce distinct effects on the cardiac and pcp-pyloric pattern generators, while the ion inputs, via the oesophageal ganglion, excite only the pcp-pyloric generator.On the basis of anatomical and physiological observations, the possible functions of motor neurons involved in the pcp-pyloric cycle are described with reference to opening of the pcp and pyloric channels.This stomatogastric nervous system inSquilla is compared to that in decapods which has been well analyzed.Abbreviations
CG
commissural ganglion
-
ion
inferior oesophageal nerve
-
lvn
lateral ventricular nerve
-
OG
oesophageal ganglion
-
pep
posterior cardiac plate
-
son
superior oesophageal nerve
-
STG
stomatogastric ganglion
-
stn
stomatogastric nerve
-
ivn
inferior ventricular nerve 相似文献
76.
Following four hypotheses on the production of soldiers were tested in the Pheidole fervida colonies collected in the natural field:
- The proportion of new soldiers is primarily dependent on the population size of old workers.
- The abundance of old soldiers reduces the proportion of new soldiers.
- The production of sexuals reduces the proportion of new soldiers.
- The number of soldiers is correlated with the size of defense zone.
77.
Koichiro Fukuoka Fuminori Suda Ryo Suzuki Masahide Ishikawa Hiroshi Takaku Tsujiaki Hata 《Nucleosides, nucleotides & nucleic acids》2013,32(6-7):1557-1567
Abstract Bifunctional phosphorylating reagents 1 and 2 were employed for the synthesis of the cap part, m7G7 pppG, from guanosine 5′-phosphates on a large scale without any protecting groups. 相似文献
78.
We describe a strategy to establish cyanobacterial strains with high levels of H2 production that involves the identification of promising wild-type strains followed by optimization of the selected strains
using genetic engineering. Nostoc sp. PCC 7422 was chosen from 12 other heterocystous strains, because it has the highest nitrogenase activity. We sequenced
the uptake hydrogenase (Hup) gene cluster as well as the bidirectional hydrogenase gene cluster from the strain, and constructed
a mutant (ΔhupL) by insertional disruption of the hupL gene. The ΔhupL mutant produced H2 at 100 μmoles mg chlorophyll a
-1 h-1, a rate three times that of the wild-type. The ΔhupL cells could accumulate H2 to about 29% (v/v) accompanied by O2 evolution in 6 days, under a starting gas phase of Ar + 5% CO2. The presence of 20% O2 in the initial gas phase inhibited H2 accumulation of the ΔhupL cells by less than 20% until day 7. 相似文献
79.
Fuminori Tokunaga Hiroshi Nishimasu Ryuichiro Ishitani Eiji Goto Takuya Noguchi Kazuhiro Mio Kiyoko Kamei Averil Ma Kazuhiro Iwai Osamu Nureki 《The EMBO journal》2012,31(19):3856-3870
LUBAC (linear ubiquitin chain assembly complex) activates the canonical NF-κB pathway through linear polyubiquitination of NEMO (NF-κB essential modulator, also known as IKKγ) and RIP1. However, the regulatory mechanism of LUBAC-mediated NF-κB activation remains elusive. Here, we show that A20 suppresses LUBAC-mediated NF-κB activation by binding linear polyubiquitin via the C-terminal seventh zinc finger (ZF7), whereas CYLD suppresses it through deubiquitinase (DUB) activity. We determined the crystal structures of A20 ZF7 in complex with linear diubiquitin at 1.70–1.98 Å resolutions. The crystal structures revealed that A20 ZF7 simultaneously recognizes the Met1-linked proximal and distal ubiquitins, and that genetic mutations associated with B cell lymphomas map to the ubiquitin-binding sites. Our functional analysis indicated that the binding of A20 ZF7 to linear polyubiquitin contributes to the recruitment of A20 into a TNF receptor (TNFR) signalling complex containing LUBAC and IκB kinase (IKK), which results in NF-κB suppression. These findings provide new insight into the regulation of immune and inflammatory responses. 相似文献
80.
Dopamine selectively induces migration and homing of naive CD8+ T cells via dopamine receptor D3 总被引:1,自引:0,他引:1
Watanabe Y Nakayama T Nagakubo D Hieshima K Jin Z Katou F Hashimoto K Yoshie O 《Journal of immunology (Baltimore, Md. : 1950)》2006,176(2):848-856
The nervous systems affect immune functions by releasing neurohormones and neurotransmitters. A neurotransmitter dopamine signals via five different seven-transmembrane G protein-coupled receptors termed D1 to D5. The secondary lymphoid tissues are highly innervated by sympathetic nerve fibers that store dopamine at high contents. Lymphocytes also produce dopamine. In this study, we examined expression and function of dopamine receptors in lymphocytes. We found that D3 was the predominant subtype of dopamine receptors in the secondary lymphoid tissues and selectively expressed by naive CD8+ T cells of both humans and mice. Dopamine induced calcium flux and chemotaxis in mouse L1.2 cells stably expressing human D3. These responses were almost completely inhibited by pertussis toxin, indicating that D3 was coupled with the Galphai class of G proteins. Consistently, dopamine selectively induced chemotactic responses in naive CD8+ T cells of both humans and mice in a manner sensitive to pertussis toxin and D3 antagonists. Dopamine was highly synergistic with CCL19, CCL21, and CXCL12 in induction of chemotaxis in naive CD8+ T cells. Dopamine selectively induced adhesion of naive CD8+ T cells to fibronectin and ICAM-1 through activation of integrins. Intraperitoneal injection of mice with dopamine selectively attracted naive CD8+ T cells into the peritoneal cavity. Treatment of mice with a D3 antagonist U-99194A selectively reduced homing of naive CD8+ T cells into lymph nodes. Collectively, naive CD8+ T cells selectively express D3 in both humans and mice, and dopamine plays a significant role in migration and homing of naive CD8+ T cells via D3. 相似文献