全文获取类型
收费全文 | 358篇 |
免费 | 35篇 |
专业分类
393篇 |
出版年
2022年 | 5篇 |
2021年 | 6篇 |
2019年 | 6篇 |
2018年 | 10篇 |
2017年 | 9篇 |
2016年 | 12篇 |
2015年 | 6篇 |
2014年 | 6篇 |
2013年 | 12篇 |
2012年 | 12篇 |
2011年 | 20篇 |
2010年 | 10篇 |
2009年 | 5篇 |
2008年 | 17篇 |
2007年 | 18篇 |
2006年 | 20篇 |
2005年 | 15篇 |
2004年 | 14篇 |
2003年 | 11篇 |
2002年 | 10篇 |
2001年 | 11篇 |
2000年 | 26篇 |
1999年 | 7篇 |
1998年 | 3篇 |
1997年 | 4篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1991年 | 9篇 |
1990年 | 7篇 |
1989年 | 10篇 |
1988年 | 10篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 4篇 |
1984年 | 6篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 5篇 |
1975年 | 4篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1970年 | 5篇 |
1969年 | 2篇 |
1968年 | 2篇 |
1967年 | 2篇 |
1966年 | 6篇 |
排序方式: 共有393条查询结果,搜索用时 15 毫秒
41.
42.
Polshakov VI Eliseev BD Birdsall B Frolova LY 《Protein science : a publication of the Protein Society》2012,21(6):896-903
The high-resolution NMR structure of the N-domain of human eRF1, responsible for stop codon recognition, has been determined in solution. The overall fold of the protein is the same as that found in the crystal structure. However, the structures of several loops, including those participating in stop codon decoding, are different. Analysis of the NMR relaxation data reveals that most of the regions with the highest structural discrepancy between the solution and solid states undergo internal motions on the ps-ns and ms time scales. The NMR data show that the N-domain of human eRF1 exists in two conformational states. The distribution of the residues having the largest chemical shift differences between the two forms indicates that helices α2 and α3, with the NIKS loop between them, can switch their orientation relative to the β-core of the protein. Such structural plasticity may be essential for stop codon recognition by human eRF1. 相似文献
43.
44.
45.
G R Matsevich M A Frolova R G Gudkova 《Zhurnal mikrobiologii, epidemiologii, i immunobiologii》1978,(4):24-26
Experiments were conducted on guinea pigs with the use of cell migration inhibition test of the peritoneal exudate; stimulation of a definite level of cell immunity in response to the administration of both live and of inactivated vaccine virus was shown. The results obtained are used for the interpretation of the action mechanism of the inactivated preparation in two-stage smallpox vaccination. 相似文献
46.
47.
48.
49.
50.
Leslie Edwards Danielle Turner Cody Champion Megha Khandelwal Kailee Zingler Cassidy Stone Ruwini D. Rajapaksha Jing Yang Mahinda I. Ranasinghe Alexander Kornienko Liliya V. Frolova Snezna Rogelj 《Bioorganic & medicinal chemistry letters》2018,28(10):1879-1886
Compounds based on the 2,3-distyrylindole scaffold were found to exhibit bactericidal properties upon irradiation with white light. At the concentration of 1?μM, the lead compound 1 completely (ca. 109?CFU/mL) eradicated such Gram-positive organisms as S. aureus (MRSA, MSSA), E. faecalis (VRE), S. pyogenes and S. mutans when irradiated with white light for 2?min. At the concentration of 5?μM and in the presence of polymyxin E at non-bactericidal 1.25?μg/mL concentration, 1 also showed a 7-log to 9-log reductions in bacterial counts of such Gram-negative organisms as multi-drug resistant (MDR) A. baumannii, MDR P. aeruginosa, E. coli and Klebsiella pneumoniae (CRE: KPC and NDM-1), also when irradiated with white light for 2?min. The structure-activity relationship studies revealed that unsubstituted at benzene rings 2,3-distyrylindole 2 was most potent and gave a 5-order of magnitude eradication of a MRSA strain at the concentration of 30?nM upon irradiation with white light. Initial mechanistic experiments revealed the disruption of bacterial cell membrane, but indicated that singlet oxygen production, which is commonly associated with photodynamic therapy, may not play a role in the bactericidal effects of the 2,3-distyrylindoles. 相似文献