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101.
102.
Sebastian Schlafer Birgit Riep Ann L Griffen Annett Petrich Julia Hübner Moritz Berning Anton Friedmann Ulf B Göbel Annette Moter 《BMC microbiology》2010,10(1):66
Background
Bacteria in periodontal pockets develop complex sessile communities that attach to the tooth surface. These highly dynamic microfloral environments challenge both clinicians and researchers alike. The exploration of structural organisation and bacterial interactions within these biofilms is critically important for a thorough understanding of periodontal disease. In recent years, Filifactor alocis, a fastidious, Gram-positive, obligately anaerobic rod was repeatedly identified in periodontal lesions using DNA-based methods. It has been suggested to be a marker for periodontal deterioration. The present study investigated the epidemiology of F. alocis in periodontal pockets and analysed the spatial arrangement and architectural role of the organism in in vivo grown subgingival biofilms. 相似文献103.
104.
Hormone sensitive calcium uptake by liver microsomes 总被引:2,自引:0,他引:2
The effects of glucagon and insulin on hepatic microsomal calcium uptake were investigated. Microsomes isolated from perfused rat liver accumulated calcium in the presence of ATP and oxalate. Addition of glucagon to the perfusate significantly increased calcium uptake by microsomes subsequently isolated. In contrast, addition of insulin to the perfusate resulted in a decreased microsomal calcium uptake and inhibition of the glucagon effect. Because the effects of glucagon and insulin on hepatic microsomal calcium uptake are opposite, as are the metabolic effects of these hormones, it is likely that the observed differences are of physiological importance. 相似文献
105.
Dissociation of esterolytic and clotting activities of thrombin by trypsin-binding macroglobulin 总被引:18,自引:0,他引:18
106.
The effects of glucagon and insulin administration on hepatic mitochondrial Ca2+ uptake were compared with the effects of these hormones when they were added directly to the perfused liver. Glucagon administration increased mitochondrial calcium uptake both and in the perfused liver. In contrast, while injection of insulin into rats stimulated, addition of insulin to the perfusate, inhibited Ca2+ uptake. Cyclic AMP, when added to the perfusate, also increased the uptake of Ca2+ by mitochondria, subsequently isolated. The possible implications of the results are discussed. 相似文献
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108.
Alzheimer's disease‐causing proline substitutions lead to presenilin 1 aggregation and malfunction
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Tziona Ben‐Gedalya Lorna Moll Michal Bejerano‐Sagie Samuel Frere Wayne A Cabral Dinorah Friedmann‐Morvinski Inna Slutsky Tal Burstyn‐Cohen Joan C Marini Ehud Cohen 《The EMBO journal》2015,34(22):2820-2839
Do different neurodegenerative maladies emanate from the failure of a mutual protein folding mechanism? We have addressed this question by comparing mutational patterns that are linked to the manifestation of distinct neurodegenerative disorders and identified similar neurodegeneration‐linked proline substitutions in the prion protein and in presenilin 1 that underlie the development of a prion disorder and of familial Alzheimer's disease (fAD), respectively. These substitutions were found to prevent the endoplasmic reticulum (ER)‐resident chaperone, cyclophilin B, from assisting presenilin 1 to fold properly, leading to its aggregation, deposition in the ER, reduction of γ‐secretase activity, and impaired mitochondrial distribution and function. Similarly, reduced quantities of the processed, active presenilin 1 were observed in brains of cyclophilin B knockout mice. These discoveries imply that reduced cyclophilin activity contributes to the development of distinct neurodegenerative disorders, propose a novel mechanism for the development of certain fAD cases, and support the emerging theme that this disorder can stem from aberrant presenilin 1 function. This study also points at ER chaperones as targets for the development of counter‐neurodegeneration therapies. 相似文献
109.