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Andrea Thieme Beate Mitulla Friedemann Schulze Aribert W. J. Spiegier 《Human genetics》1993,91(3):295-297
This study contains the largest body of epidemiological data on Werdnig-Hoffmann disease (acute infantile spinal muscular atrophy; ASMA) in West-Thüringen in Germany. The incidence of ASMA was calculated to be 1 in 10202 live births. The prevalence was 1 in 595362 of the general population (as of 31 December 1987). The study gives an unexpectedly high incidence rate confirming the suggestion that ASMA in Central and Eastern Europe might be more frequent than in Western Europe. However, we consider that this high incidence rate in West-Thüringen is a result of the almost complete ascertainment made possible because of the well-organised and centralised health system existing in Thüringen over the last few decades. 相似文献
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Claudia Schiffczyk Barbara Romero Christina Jonas Constanze Lahmeyer Friedemann Müller Matthias W Riepe 《BMC neurology》2010,10(1):48
Background
Quality of life (QoL) is increasingly used to characterize the impact of disease and the efficacy of interventions. 相似文献224.
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Friedemann Awiszus 《Biological cybernetics》1993,68(6):553-558
There are several different strategies to control the timing of a stimulus with respect to the ongoing discharge during the recording of neuronal stimulus-response characteristics. One possible strategy consists of delivering stimuli in such a way that a constant pre-stimulus spike density is reached. Another strategy enforces spike application with a constant stimulus latency after a spontaneous discharge. In this paper the sensitivity of these different strategies for statistical verification of small excitatory response components was investigated. It was found that the difference between observed poststimulus spike distribution and expected spike distribution under the null hypothesis of no stimulus effect was larger using a constant-stimulus-latency (CSL) strategy with an appropriate value for the stimulus latency. Thus, the statistical verification of neuronal response components is clearly facilitated if a CSL strategy is used. This superiority of the CSL strategy is marked, especially for small excitations at neurons discharging slowly with low discharge variability. 相似文献