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Fridolin Krasser 《Plant Systematics and Evolution》1885,35(11):373-377
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Thomas Pradeu Bertrand Daignan-Fornier Andrew Ewald Pierre-Luc Germain Samir Okasha Anya Plutynski Sébastien Benzekry Marta Bertolaso Mina Bissell Joel S. Brown Benjamin Chin-Yee Ian Chin-Yee Hans Clevers Laurent Cognet Marie Darrason Emmanuel Farge Jean Feunteun Jérôme Galon Elodie Giroux Sara Green Fridolin Gross Fanny Jaulin Rob Knight Ezio Laconi Nicolas Larmonier Carlo Maley Alberto Mantovani Violaine Moreau Pierre Nassoy Elena Rondeau David Santamaria Catherine M. Sawai Andrei Seluanov Gregory D. Sepich-Poore Vanja Sisirak Eric Solary Sarah Yvonnet Lucie Laplane 《Biological reviews of the Cambridge Philosophical Society》2023,98(5):1668-1686
Cancers rely on multiple, heterogeneous processes at different scales, pertaining to many biomedical fields. Therefore, understanding cancer is necessarily an interdisciplinary task that requires placing specialised experimental and clinical research into a broader conceptual, theoretical, and methodological framework. Without such a framework, oncology will collect piecemeal results, with scant dialogue between the different scientific communities studying cancer. We argue that one important way forward in service of a more successful dialogue is through greater integration of applied sciences (experimental and clinical) with conceptual and theoretical approaches, informed by philosophical methods. By way of illustration, we explore six central themes: (i) the role of mutations in cancer; (ii) the clonal evolution of cancer cells; (iii) the relationship between cancer and multicellularity; (iv) the tumour microenvironment; (v) the immune system; and (vi) stem cells. In each case, we examine open questions in the scientific literature through a philosophical methodology and show the benefit of such a synergy for the scientific and medical understanding of cancer. 相似文献
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Dr. Fridolin Krasser 《Plant Systematics and Evolution》1897,47(8):273-281
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Dr. Fridolin Krasser 《Plant Systematics and Evolution》1897,47(10):349-356
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Dr. Fridolin Krasser 《Plant Systematics and Evolution》1893,43(1):14-22
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