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1.
2.
Serially propagated with 3T3 feeder layer support, epithelial cells derived from normal rat endometrium expressed estrogen receptor activity. Specific binding of 17-beta-estradiol was in the range of 30-60 fmol/mg of protein and was of high affinity (Kd = 0.3 nM). A survey of cell lines derived from several other normal epithelia showed that rat vaginal and human cervical cultures also had high-affinity estrogen receptors (6-13 fmol/mg of protein), while rat epidermal and esophageal cells had no detectable activity. In the endometrial cultures, receptor levels were elevated nearly two- to fourfold by cholera toxin or forskolin in the medium. This effect was detectable after 4 hr but not 1 hr of treatment and did not occur in the presence of cycloheximide. We conclude that serially cultivated rat endometrial cells retain hormonal properties expressed in vivo while exhibiting some keratinocyte character. These cells may provide a useful model for study of receptor modulation. 相似文献
3.
Sea urchins have elaborated multiple defenses to assure monospermic fertilization. In this work, we have concentrated on a study of the mechanism(s) by which hydrogen peroxide (H2O2) prevents polyspermy in Arbacia punctulata. We found that it is not H2O2 but probably hypochlorous acid/hypochlorite (HOCl/OCl?) derived from H2O2 that is toxic to the supernumerary sperm. The spermicidal activity of H2O2 is potentiated by at least one order of magnitude by cupric ions (Cu2+). This increased toxicity is not due to the formation of hydroxyl radicals (·OH) because ·OH scavengers did not counteract the activity of Cu2+. More-over, substitution of Cu2+ by ferrous ions (Fe2+), which are known to cause formation of ·OH from H2O2, had no effect on fertilization even at 102?103 times higher concentrations. In contrast, 3-amino-1,2,4-triazole (AT), an HOCl/OCl? scavenger, totally reversed the toxic effects of Cu2+. Furthermore, we found that HOCl/OCl? is generated in solutions of H2O2 and Cu2+ in the presence of 0.5 M NaCl and that its accumulation is abolished by AT. Thus it is possible that the antifertility properties of copper are due to its ability to mediate formation of HOCl/OCl?. HOCl/OCl? generated by Cu2+ from H2O2 and Cl?, a low concentration of exogenously added HOCl/OCl?, or increased concentrations of H2O2 has similar inhibitory effects on the fertilization process in sea urchins. Therefore, we suggest that polyspermy is prevented by the action of a myeloperoxidase that affects the formation of HOCl/OCl? from the Cl? present in sea water through reaction with H2O2 generated by the newly fertilized egg. 相似文献
4.
Plastids affected by either iojap or chloroplast mutator fail to green, and altered plastids are maternally transmitted to subsequent generations. The ultrastructure of iojap-affected plastids indicates that these plastids contain no ribosomes and are capable of supporting little internal membrane organization in either light or dark-grown plants. Chloroplast mutator-affected plastids of light-grown plants contain some organized internal membrane structures. In dark-grown plants, chloroplast mutator-aftected plastids contain a crystalline prolamellar body, numerous vesicles, and osmiophilic granules. The chloroplast mutator-affecled etioplasts display an abnormal distribution of lamellar membranes; these membranes, rather than radiating in a spokelike pattern from the prolamellar body, are condensed into a portion of the organelle. Light causes disruption of the prolamellar body in chloroplast mutator-affected plastids without promoting the organization of a normal thylakoid membrane system. The effects of iojap and chloroplast mutator are cell autonomous and apparently influence the individual plastid, as evidenced by the persistence of heteroplastidic cells containing normal and affected plastids. 相似文献
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6.
Book reviewed in this article:
ARCHEOLOGY: Papers of the New World Archaeological Foundation
No. 6. The Carved Human Femurs from Tomb 1, Chiapa de Corzo, Chiapas, Mexico . P ierre A grinier
No. 7. Archaeological Explorations in the Region of the Frailesca, Chiapas, Mexico . C arlos N avarrete
Nos. 8–11. Excavations at Chiapa de Corzo, Chiapas, Mexico . G areth W. L owe
No. 12. Mound 5 and Minor Excavations, Chiapa de Corzo, Chiapas, Mexico . G areth W. L owe
No. 13. Ceramic Stratigraphy at Santa Cruz, Chiapas, Mexico . W illiam T. S anders
No. 14. The Santa Marta Rock Shelter, Ocozocoautla, Chiapas, Mexico . R ichard S. M ac N eish and F redrick A. P eterson 相似文献
ARCHEOLOGY: Papers of the New World Archaeological Foundation
No. 6. The Carved Human Femurs from Tomb 1, Chiapa de Corzo, Chiapas, Mexico . P ierre A grinier
No. 7. Archaeological Explorations in the Region of the Frailesca, Chiapas, Mexico . C arlos N avarrete
Nos. 8–11. Excavations at Chiapa de Corzo, Chiapas, Mexico . G areth W. L owe
No. 12. Mound 5 and Minor Excavations, Chiapa de Corzo, Chiapas, Mexico . G areth W. L owe
No. 13. Ceramic Stratigraphy at Santa Cruz, Chiapas, Mexico . W illiam T. S anders
No. 14. The Santa Marta Rock Shelter, Ocozocoautla, Chiapas, Mexico . R ichard S. M ac N eish and F redrick A. P eterson 相似文献
7.
The properties, origin, and mechanism of conversion-type inheritance at the B locus in maize 总被引:4,自引:3,他引:1 下载免费PDF全文
Coe EH 《Genetics》1966,53(6):1035-1063
8.
9.
Book reviewed in this article:
LINGUISTICS: Pis'mennost'
LINGUISTICS: Pis'mennost'
10.
Previous references to "necking" behaviour, and the main features of the study area are briefly outlined.
"Necking" behaviour in giraffe takes place only in all male herds. When the animals are in a head to head posture the intensity is either high or low, but when animals take up a head to tail posture the actions are always of high intensity and appear to have greater sexual significance.
The significance of "necking" is discussed, and it is suggested that these ritualized actions form an important sexuo-social bonding mechanism whereby a hierarchy is created amongst the males, and movement between strictly bachelor and mixed herds helps to maintain contact between the sexes in this polygamous mammal. 相似文献
"Necking" behaviour in giraffe takes place only in all male herds. When the animals are in a head to head posture the intensity is either high or low, but when animals take up a head to tail posture the actions are always of high intensity and appear to have greater sexual significance.
The significance of "necking" is discussed, and it is suggested that these ritualized actions form an important sexuo-social bonding mechanism whereby a hierarchy is created amongst the males, and movement between strictly bachelor and mixed herds helps to maintain contact between the sexes in this polygamous mammal. 相似文献