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171.
Beta phorbol ester- and diacylglycerol-induced augmentation of transmitter release is mediated by Munc13s and not by PKCs. 总被引:13,自引:0,他引:13
Jeong Seop Rhee Andrea Betz Sonja Pyott Kerstin Reim Frederique Varoqueaux Iris Augustin D?rte Hesse Thomas C Südhof Masami Takahashi Christian Rosenmund Nils Brose 《Cell》2002,108(1):121-133
Munc13-1 is a presynaptic protein with an essential role in synaptic vesicle priming. It contains a diacylglycerol (DAG)/beta phorbol ester binding C(1) domain and is a potential target of the DAG second messenger pathway that may act in parallel with PKCs. Using genetically modified mice that express a DAG/beta phorbol ester binding-deficient Munc13-1(H567K) variant instead of the wild-type protein, we determined the relative contribution of PKCs and Munc13-1 to DAG/beta phorbol ester-dependent regulation of neurotransmitter release. We show that Munc13s are the main presynaptic DAG/beta phorbol ester receptors in hippocampal neurons. Modulation of Munc13-1 activity by second messengers via the DAG/beta phorbol ester binding C(1) domain is essential for use-dependent alterations of synaptic efficacy and survival. 相似文献
172.
Sergio Crespo-Garcia Pamela R. Tsuruda Agnieszka Dejda Rathi D. Ryan Frederik Fournier Shawnta Y. Chaney Frederique Pilon Taner Dogan Gael Cagnone Priyanka Patel Manuel Buscarlet Sonali Dasgupta Gabrielle Girouard Surabhi R. Rao Ariel M. Wilson Robert O’Brien Rachel Juneau Vera Guber Przemyslaw Sapieha 《Cell metabolism》2021,33(4):818-832.e7
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173.
Andrew Cristinacce Amanda Ladkoo Richard Switzer Lara Jordan Vanessa Vencatasamy Frederique de Ravel Koenig Carl Jones Diana Bell 《Zoo biology》2008,27(4):255-268
In‐situ captive rearing of endangered passerines for reintroduction has rarely been used as a conservation tool. Nests of Mauritius fodies threatened with predation by introduced mammalian predators were harvested from the wild, and chicks were reared to independence for release onto an offshore, predator‐free island. The daily probability of the survival was higher in captivity than in the wild, and 69 chicks were reared to fledging of which 47 would have been expected to fledge in the wild. Harvesting of nests probably had little impact on the wild population. Captive breeding trials on Mauritius fodies showed that large numbers of individuals could be produced for a release program from a small number of pairs if enough space was provided. Artificial incubation of passerine eggs and rearing of chicks can be used to increase the productivity of endangered taxa. Zoos can play an important role in in‐situ conservation programs through provision of avicultural expertise and training of local staff. Zoo Biol 27:255–268, 2008. © 2008 Wiley‐Liss, Inc. 相似文献
174.
Marie-Laure Guillemin Sylvain Faugeron Christophe Destombe Frederique Viard Juan A Correa Myriam Valero 《Evolution; international journal of organic evolution》2008,62(6):1500-1519
The extent of changes in genetic diversity and life-history traits associated with farming was investigated in the haploid-diploid red alga, Gracilaria chilensis, cultivated in Chile. This alga belongs to one of the most frequently cultivated seaweed genera around the world. Fifteen farmed populations, 11 wild populations, and two subspontaneous populations were sampled along the Chilean coast. The frequency of reproductive versus vegetative individuals and of haploid versus diploid individuals was checked in each population. In addition, the distribution of genetic variation in wild and cultivated populations was analyzed using six microsatellite markers. Our results first demonstrated that farmed populations are maintained almost exclusively by vegetative propagation. Moreover, the predominance of diploid individuals in farms showed that farming practices had significantly modified life-history traits as compared to wild populations. Second, the expected reduction in genetic diversity due to a cultivation bottleneck and subsequent clonal propagation was detected in farms. Finally, our study suggested that cultural practices in the southern part of the country contributed to the spread of selected genotypes at a local scale. Altogether, these results document for the first time that involuntary selection could operate during the first step of domestication in a marine plant. 相似文献