全文获取类型
收费全文 | 183篇 |
免费 | 15篇 |
出版年
2022年 | 2篇 |
2021年 | 3篇 |
2019年 | 3篇 |
2016年 | 3篇 |
2015年 | 5篇 |
2014年 | 5篇 |
2013年 | 9篇 |
2012年 | 11篇 |
2011年 | 9篇 |
2010年 | 3篇 |
2009年 | 5篇 |
2008年 | 7篇 |
2007年 | 7篇 |
2006年 | 6篇 |
2005年 | 2篇 |
2004年 | 9篇 |
2003年 | 5篇 |
2002年 | 6篇 |
2001年 | 5篇 |
2000年 | 6篇 |
1999年 | 4篇 |
1998年 | 3篇 |
1997年 | 5篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1993年 | 3篇 |
1992年 | 2篇 |
1991年 | 7篇 |
1990年 | 5篇 |
1989年 | 3篇 |
1988年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 2篇 |
1981年 | 6篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 2篇 |
1977年 | 1篇 |
1976年 | 2篇 |
1975年 | 1篇 |
1974年 | 3篇 |
1973年 | 2篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1968年 | 2篇 |
1966年 | 1篇 |
1964年 | 1篇 |
1951年 | 3篇 |
1950年 | 1篇 |
排序方式: 共有198条查询结果,搜索用时 14 毫秒
31.
Janne Bigaard Kirsten Frederiksen Anne Tjnneland Birthe Lykke Thomsen Kim Overvad Berit Lillienthal Heitmann Thorkild I.A. Srensen 《Obesity (Silver Spring, Md.)》2004,12(7):1042-1049
Objective: To investigate whether the association between BMI and all‐cause mortality could be disentangled into opposite effects of body fat and fat‐free mass (FFM). Research Methods and Procedures: All‐cause mortality was studied in the Danish follow‐up study “Diet, Cancer and Health” with 27, 178 men and 29, 875 women 50 to 64 years old recruited from 1993 to 1997. By the end of year 2001, the median follow‐up was 5.8 years, and 1851 had died. Body composition was assessed by bioelectrical impedance. Cox regression models were used to estimate the relationships among body fat mass index (body fat mass divided by height squared), FFM index (FFM divided by height squared), and mortality. All analyses were adjusted for smoking habits. Results: Men and women showed similar associations. J‐shaped associations were found between body fat mass index and mortality adjusted for FFM and smoking. The mortality rate ratios in the upper part of body fat mass were 1.12 per kg/m2 (95% confidence interval: 1.07, 1.18) in men and 1.06 per kg/m2 (95% confidence interval: 1.02, 1.10) in women. Reversed J‐shaped associations were found between FFM index and mortality with a tendency to level off for high values of FFM. Discussion: Our findings suggest that BMI represents joint but opposite associations of body fat and FFM with mortality. Both high body fat and low FFM are independent predictors of all‐cause mortality. 相似文献
32.
A recombinant plasmid, pMLY12-1, screened from a Peronosclerospora sorghi library hybridizes only to DNA of P. sorghi, or to DNA from leaves infected with P. sorghi, not to DNA of P. sorghi Thailand isolate, P. philippinensis, P. sacchari, or P. maydis. The terminal sequences of the 1.3-kb insert, which appears to contain mitochondrial DNA, are 85% A and T. No polymorphisms were detected when the probe was hybridized to Southern blots containing DNA from P. sorghi pathotype 1, pathotype 3, or a Botswana isolate digested with any of the eight restriction endonucleases tested. The banding patterns were the same whether DNA was extracted directly from the fungus or from infected leaves. 相似文献
33.
Synthesis of low molecular weight RNA components in cells with a temperature-sensitive polymerase II 总被引:6,自引:0,他引:6
AF 8 cells are a mutant cell line of baby hamster kidney cells with a temperature-sensitive polymerase II activity. When these cells grow at the non-permissive temperature (40 degrees C) the syntheseis of low molecular weight RNA components D, C and A is preferentially inhibited, whereas the synthesis of rRNA, tRNA, 5 S RNA and component L is affected only a little or not at all. These results indicate that polymerase II catalyzes the synthesis of components D, C and A. 相似文献
34.
35.
LORENTE R DE NO R 《The Journal of general physiology》1951,35(2):183-201
The Et class of fibers includes fibers of Gasser's d.r. C group. The fibers of the dorsal root are more sensitive to the effect of lack of sodium than are the fibers of the ventral root. In the two roots there is a gradient of sensitivity to the lack of sodium, which is such that in all the root fibers the sensitivity decreases with increasing distance from the spinal cord. The gradient continues in the trunk up to about 10 to 12 mm. peripheral to the trunk-roots margin. No comparable gradient of sensitivity to the lack of sodium has been observed in the rest of the nerve trunk. The gradient of sensitivity to the lack of sodium has no relationship to the anatomical distribution of the epineurium. As a working hypothesis it is suggested that the gradient of sensitivity to the lack of sodium is one aspect of a transitional gradient that serves to establish a gradual change between the properties that the axons have inside the spinal cord and the properties that they have inside the nerve trunks. Details are given of the temporal course of the loss of excitability by root fibers deprived of sodium. It is suggested that sodium is present in the nerve fibers, in 2 forms, loosely and tightly bound sodium and that loss of loosely bound sodium is sufficient to render the nerve fibers unable to conduct impulses. If the rate of loss of loosely bound sodium is decreased, conversion of tightly bound into loosely bound sodium may temporarily restore the excitability of the nerve fibers. 相似文献
36.
S Frederiksen 《Archives of biochemistry and biophysics》1966,113(2):383-388
37.
38.
Siem Jakob Veenstra Heinrich Rueeger Markus Voegtle Rainer Lueoend Philipp Holzer Konstanze Hurth Marina Tintelnot-Blomley Mathias Frederiksen Jean-Michel Rondeau Laura Jacobson Matthias Staufenbiel Ulf Neumann Rainer Machauer 《Bioorganic & medicinal chemistry letters》2018,28(12):2195-2200
New amino-1,4-oxazine derived BACE-1 inhibitors were explored and various synthetic routes developed. The binding mode of the inhibitors was elucidated by co-crystallization of 4 with BACE-1 and X-ray analysis. Subsequent optimization led to inhibitors with low double digit nanomolar activity in a biochemical and single digit nanomolar potency in a cellular assays. To assess the inhibitors for their permeation properties and potential to cross the blood-brain-barrier a MDR1-MDCK cell model was successfully applied. Compound 8a confirmed the in vitro results by dose-dependently reducing Aβ levels in mice in an acute treatment regimen. 相似文献
39.
40.
A taxonomic revision of the genus Hystrix (Triticeae, Poaceae) 总被引:1,自引:0,他引:1