全文获取类型
收费全文 | 1480篇 |
免费 | 147篇 |
国内免费 | 2篇 |
出版年
2023年 | 9篇 |
2022年 | 11篇 |
2021年 | 31篇 |
2020年 | 14篇 |
2019年 | 17篇 |
2018年 | 24篇 |
2017年 | 20篇 |
2016年 | 36篇 |
2015年 | 61篇 |
2014年 | 75篇 |
2013年 | 94篇 |
2012年 | 119篇 |
2011年 | 105篇 |
2010年 | 67篇 |
2009年 | 76篇 |
2008年 | 102篇 |
2007年 | 97篇 |
2006年 | 79篇 |
2005年 | 86篇 |
2004年 | 71篇 |
2003年 | 74篇 |
2002年 | 84篇 |
2001年 | 13篇 |
2000年 | 8篇 |
1999年 | 10篇 |
1998年 | 17篇 |
1997年 | 15篇 |
1996年 | 8篇 |
1995年 | 9篇 |
1994年 | 6篇 |
1993年 | 5篇 |
1992年 | 5篇 |
1990年 | 6篇 |
1988年 | 6篇 |
1986年 | 5篇 |
1985年 | 8篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 10篇 |
1980年 | 5篇 |
1978年 | 5篇 |
1974年 | 6篇 |
1973年 | 4篇 |
1971年 | 4篇 |
1969年 | 4篇 |
1966年 | 4篇 |
1908年 | 5篇 |
1899年 | 3篇 |
1889年 | 4篇 |
1887年 | 3篇 |
排序方式: 共有1629条查询结果,搜索用时 15 毫秒
51.
Jacqueline MacDonald Gibson Jens Thomsen Frederic Launay Elizabeth Harder Nicholas DeFelice 《PloS one》2013,8(3)
Background
This study estimates the potential health gains achievable in the United Arab Emirates (UAE) with improved controls on environmental pollution. The UAE is an emerging economy in which population health risks have shifted rapidly from infectious diseases to chronic conditions observed in developed nations. The UAE government commissioned this work as part of an environmental health strategic planning project intended to address this shift in the nature of the country’s disease burden.Methods and Findings
We assessed the burden of disease attributable to six environmental exposure routes outdoor air, indoor air, drinking water, coastal water, occupational environments, and climate change. For every exposure route, we integrated UAE environmental monitoring and public health data in a spatially resolved Monte Carlo simulation model to estimate the annual disease burden attributable to selected pollutants. The assessment included the entire UAE population (4.5 million for the year of analysis). The study found that outdoor air pollution was the leading contributor to mortality, with 651 attributable deaths (95% confidence interval [CI] 143–1,440), or 7.3% of all deaths. Indoor air pollution and occupational exposures were the second and third leading contributors to mortality, with 153 (95% CI 85–216) and 46 attributable deaths (95% CI 26–72), respectively. The leading contributor to health-care facility visits was drinking water pollution, to which 46,600 (95% CI 15,300–61,400) health-care facility visits were attributed (about 15% of the visits for all the diseases considered in this study). Major study limitations included (1) a lack of information needed to translate health-care facility visits to quality-adjusted-life-year estimates and (2) insufficient spatial coverage of environmental data.Conclusions
Based on international comparisons, the UAE’s environmental disease burden is low for all factors except outdoor air pollution. From a public health perspective, reducing pollutant emissions to outdoor air should be a high priority for the UAE’s environmental agencies. 相似文献52.
Alistar Ottochian Chiara Ricca Frederic Labat Carlo Adamo 《Journal of molecular modeling》2016,22(3):61
The diffusion and ionic conductivity of Li x Na1?x CO3 salt mixtures were studied by means of Molecular Dynamics (MD) simulations, using the Janssen and Tissen model (Janssen and Tissen, Mol Simul 5:83–98; 1990). These salts have received particular attention due to their central role in fuel cells technology, and reliable numerical methods that could perform as important interpretative tool of experimental data are thus required but still lacking. The chosen computational model nicely reproduces the main structural behaviour of the pure Li2CO3, Na2CO3 and K2CO3 carbonates, but also of their Li/K and Li/Na mixtures. However, it fails to accurately describe dynamic properties such as activation energies of diffusion and conduction processes, outlining the need to develop more accurate models for the simulation of molten salt carbonates. 相似文献
53.
Olaia Liñero Jean-Yves Cornu Frederic Candaudap Oleg S. Pokrovsky Sylvie Bussière Cécile Coriou Théophile Humann-Guilleminot Thierry Robert Stéphane Thunot Alberto de Diego Christophe Nguyen 《Plant and Soil》2016,408(1-2):163-181
Aims
This work concentrated on understanding the allocation of Cd recently taken up between the organs of sunflower at early and middle reproductive growth stages. The roles of transpiration and allometry were investigated.Methods
Sunflowers were grown hydroponically in greenhouse, being exposed to low concentrations of Cd (pCd2+ = 11.03). At flower bud and grain filling stages, plants were exposed for three days to 111Cd and at the same time, subjected or not to fans to increase the transpiration. The partitioning of 111Cd between plant organs measured by high resolution ICP-MS was then modelled.Results
Although the use of fans increased the plant water uptake and transpiration by about 20%, there were no significant effects on the partitioning of recent Cd. Most of the recent Cd was recovered in roots (60%) and only 2.8% were found in seeds (0.8% for the husk and 2.0% for the almonds). The sequestration of recent Cd in a plant organ was successfully explained by its biomass and except for leaves, by the biomass of other organs acting as competitive sinks.Conclusions
This work proposes a modelling approach for the partitioning of the labelled Cd between plant organs in sunflower.54.
Frederic Bartumeus Daniel Campos William S. Ryu Roger Lloret‐Cabot Vicenç Méndez Jordi Catalan 《Ecology letters》2016,19(11):1299-1313
Understanding the structural complexity and the main drivers of animal search behaviour is pivotal to foraging ecology. Yet, the role of uncertainty as a generative mechanism of movement patterns is poorly understood. Novel insights from search theory suggest that organisms should collect and assess new information from the environment by producing complex exploratory strategies. Based on an extension of the first passage time theory, and using simple equations and simulations, we unveil the elementary heuristics behind search behaviour. In particular, we show that normal diffusion is not enough for determining optimal exploratory behaviour but anomalous diffusion is required. Searching organisms go through two critical sequential phases (approach and detection) and experience fundamental search tradeoffs that may limit their encounter rates. Using experimental data, we show that biological search includes elements not fully considered in contemporary physical search theory. In particular, the need to consider search movement as a non‐stationary process that brings the organism from one informational state to another. For example, the transition from remaining in an area to departing from it may occur through an exploratory state where cognitive search is challenged. Therefore, a more comprehensive view of foraging ecology requires including current perspectives about movement under uncertainty. 相似文献
55.
56.
Robert M. W. Ferguson Sonia Garcia‐Alcega Frederic Coulon Alex J. Dumbrell Corinne Whitby Ian Colbeck 《Molecular ecology resources》2019,19(3):672-690
Bioaerosols (or biogenic aerosols) have largely been overlooked by molecular ecologists. However, this is rapidly changing as bioaerosols play key roles in public health, environmental chemistry and the dispersal ecology of microbes. Due to the low environmental concentrations of bioaerosols, collecting sufficient biomass for molecular methods is challenging. Currently, no standardized methods for bioaerosol collection for molecular ecology research exist. Each study requires a process of optimization, which greatly slows the advance of bioaerosol science. Here, we evaluated air filtration and liquid impingement for bioaerosol sampling across a range of environmental conditions. We also investigated the effect of sampling matrices, sample concentration strategies and sampling duration on DNA yield. Air filtration using polycarbonate filters gave the highest recovery, but due to the faster sampling rates possible with impingement, we recommend this method for fine ‐scale temporal/spatial ecological studies. To prevent bias for the recovery of Gram‐positive bacteria, we found that the matrix for impingement should be phosphate‐buffered saline. The optimal method for bioaerosol concentration from the liquid matrix was centrifugation. However, we also present a method using syringe filters for rapid in‐field recovery of bioaerosols from impingement samples, without compromising microbial diversity for high ‐throughput sequencing approaches. Finally, we provide a resource that enables molecular ecologists to select the most appropriate sampling strategy for their specific research question. 相似文献
57.
58.
59.
60.
De Leeuw F Zhang T Wauquier C Huez G Kruys V Gueydan C 《Experimental cell research》2007,313(20):4130-4144
The cold-inducible RNA-binding protein (CIRP) is a nuclear 18-kDa protein consisting of an amino-terminal RNA Recognition Motif (RRM) and a carboxyl-terminal domain containing several RGG motifs. First characterized for its overexpression upon cold shock, CIRP is also induced by stresses such as UV irradiation and hypoxia. Here, we investigated the expression as well as the subcellular localization of CIRP in response to other stress conditions. We demonstrate that oxidative stress leads to the migration of CIRP to stress granules (SGs) without alteration of expression. Stress granules are dynamic cytoplasmic foci at which stalled translation initiation complexes accumulate in cells subjected to environmental stress. Relocalization of CIRP into SGs also occurs upon other cytoplasmic stresses (osmotic pressure or heat shock) as well as in response to stresses of the endoplasmic reticulum. CIRP migration into SGs is independent from TIA-1 which has been previously reported to be a general mediator of SG formation, thereby suggesting the existence of multiple pathways leading to SG formation. Moreover, deletion mutants revealed that both RGG and RRM domains can independently promote CIRP migration into SGs. However, the methylation of arginine residues in the RGG domain is necessary for CIRP to exit the nucleus to be further recruited into SGs. By RNA-tethering experiments, we also show that CIRP down-regulates mRNA translation and that this activity is carried by the carboxyl-terminal RG-enriched domain. Altogether, our findings further reveal the diversity of mechanisms by which CIRP is regulated by environmental stresses and provide new insights into CIRP cytoplasmic function. 相似文献