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981.
H Van Halbeek J Breg J F Vliegenthart A Klein G Lamblin P Roussel 《European journal of biochemistry》1988,177(2):443-460
The carbohydrate chains of the respiratory-mucus glycoproteins of a patient suffering from bronchiectasis due to Kartagener's syndrome were released by alkaline borohydride treatment. Low-molecular-mass, monosialyl oligosaccharide-alditols were isolated by anion-exchange chromatography and fractionated by consecutive straight-phase high-performance liquid chromatography (HPLC) on a silica-based alkylamine column, and reverse-phase HPLC on a silica-based octadecyl column, respectively. The structures of the oligosaccharidealditols were determined by 500-MHz 1H-NMR spectroscopy in combination with sugar composition analysis. The 24 structures established range in size from disaccharides to heptasaccharides. Novel oligosaccharides obtained from the bronchiectasis mucus glycoproteins are: (formula; see text) 23 of the 24 monosialyl oligosaccharides characterized can be conceived of as extensions of neutral oligosaccharides purified from the bronchial mucus of this patient [Klein, A. et al. (1988) Eur. J. Biochem. 171, 631-642; Breg, J. et al. (1988) Eur. J Biochem. 171, 643-654]. The sialic acid residue was found to occur either in alpha (2----3)- or alpha (2----6)-linkage to a galactosyl residue or in alpha (2----6)-linkage to GalNAc-ol. 相似文献
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Kevin A. Kovalchik Qing Ma Laura Wessling Frederic Saab Jérôme D. Duquette Peter Kubiniok David J. Hamelin Pouya Faridi Chen Li Anthony W. Purcell Anne Jang Eustache Paramithiotis Marco Tognetti Lukas Reiter Roland Bruderer Joël Lanoix Éric Bonneil Mathieu Courcelles Isabelle Sirois 《Molecular & cellular proteomics : MCP》2022,21(1):100178
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986.
Nadia Sivova David Launay Lidwine Wémeau-Stervinou Pascal De Groote Martine Remy-Jardin Guillaume Denis Marc Lambert Nicolas Lamblin Sandrine Morell-Dubois Marie Fertin Guillaume Lefevre Vincent Sobanski Olivier Le Rouzic Pierre-Yves Hatron Benoit Wallaert Eric Hachulla Thierry Perez 《PloS one》2013,8(10)
We investigated whether partitioning DLCO into membrane conductance for CO (DmCO) and pulmonary capillary blood volume (Vcap) was helpful in suspecting precapillary pulmonary (arterial) hypertension (P(A)H) in systemic sclerosis (SSc) patients with or without interstitial lung disease (ILD). We included 63 SSc patients with isolated PAH (n=6), isolated ILD (n=19), association of both (n=12) or without PAH and ILD (n=26). Partitioning of DLCO was performed by the combined DLNO/DLCO method. DLCO, DmCO and Vcap were equally reduced in patients with isolated PAH and patients with isolated ILD but Vcap/alveolar volume (VA) ratio was significantly lower in the isolated PAH group. In patients without ILD, DLCO, DmCO, Vcap and Vcap/VA ratio were reduced in patients with isolated PAH when compared to patients without PAH and both Vcap/VA and DLCO had the highest AUC to detect PAH. In patients with ILD, Vcap had the highest AUC and performed better than DLCO to detect PH in this subgroup. In conclusion, Vcap/VA was lower in PAH than in ILD in SSC whereas DLCO was not different. Vcap/VA ratio and DLCO had similar high performance to detect PAH in patients without ILD. Vcap had better AUC than DLCO, DmCO and FVC/DLCO ratio to detect PH in SSC patients with ILD. These results suggest that partitioning of DLCO might be of interest to detect P(A)H in SSC patients with or without ILD. 相似文献
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Frederic Wood Jones 《BMJ (Clinical research ed.)》1908,2(2486):455-458
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