全文获取类型
收费全文 | 341篇 |
免费 | 19篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 8篇 |
2020年 | 3篇 |
2019年 | 4篇 |
2018年 | 7篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 16篇 |
2014年 | 23篇 |
2013年 | 24篇 |
2012年 | 32篇 |
2011年 | 35篇 |
2010年 | 25篇 |
2009年 | 20篇 |
2008年 | 23篇 |
2007年 | 17篇 |
2006年 | 19篇 |
2005年 | 16篇 |
2004年 | 11篇 |
2003年 | 9篇 |
2002年 | 7篇 |
2001年 | 4篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 7篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1991年 | 1篇 |
1989年 | 1篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1981年 | 1篇 |
1980年 | 2篇 |
1977年 | 1篇 |
1975年 | 1篇 |
1974年 | 1篇 |
排序方式: 共有360条查询结果,搜索用时 31 毫秒
51.
Juan Carlos Berrío Arnoud Boom Pedro José Botero Luisa Fernanda Herrera Henry Hooghiemstra Freddy Romero Gustavo Sarmiento 《Vegetation History and Archaeobotany》2001,10(3):161-174
An environmental reconstruction of the last 10,000 14C years of a frequently flooded wetland ecosystem in the lower Magdalena valley in northern Colombia is presented, on the
basis of a multi-disciplinary study of the sediments of the upper 15 m of the core from Boquillas (74°33'E, 9°7'N; 20 m a.
s. l.). We used the following studies: pollen, lithology, organic structures, clay mineralogy, soil and sediment geochemistry,
and δ13C values. The chronology is based on 13 AMS radiocarbon dates; the humic acid fractions were used in the case of seven samples.
Pollen from local origin (swamps, open grass-rich vegetation, and gallery forest) show the development of the wetland area.
River-transported pollen from a greater distance (dry forest, montane forest, Alnus) show changes in river activity and reflect large-scale changes of climatic conditions in the Momposina basin. From c. 10,010
to 9370 uncal B. P. (zone BQS-Ia) the river system was of high energy, as inferred by the lithological changes. The landscape
was dominated by open grass-rich vegetation with gallery forest along the streams. A marked representation of Alnus and montane forest taxa indicate significant water transport and river dynamics. Climatic conditions were dry. From c. 9370-8430
uncal B. P. (zone BQS-Ib) wetlands were isolated from the main river system, and clayey sediments with kaolinite, smectite
and illite as the main minerals accumulated in a lower-energy environment. Climatic conditions were dry and changes in the
seasonal precipitation favoured the expansion of the gallery forest. From c. 8430 to 8040 uncal B. P. (zone BQS-Ic) low values
of river-transported pollen indicate dry climatic conditions and open vegetation became more abundant. The flooding frequency
of the Boquillas site diminished. From 8040 to 4900 uncal B. P. (zone BQS-Id) the Boquillas site was dominated by open vegetation
with patches of gallery forest along the streams. Supply of river-transported allochthonous pollen (from many sources) was
minimal. Clay minerals from the sediments suggest variable temperature and precipitation. From c. 4900 to 1550 uncal B. P.
)zone BQS-II) the site was within the reach of the main river system as is the case today. Frequent flooding, coinciding with
peaks of river-transported grains of Alnus and high sediment supply, point to high precipitation in the composite catchment area of the Magdalena, Cauca, San Jorge,
and Cesár rivers. High values of phosphorous in the upper part of the core point to the presence of a pre-Hispanic civilization,
approximately from 2000 uncal B. P. onward. Construction of an extensive drainage system allowed irrigation as well as drainage
depending the annual cycle of precipitation. The landscape was significantly modified and allowed an extensive crop production
on a system of raised fields.
Received May 18, 2001 / Accepted June 15, 2001 相似文献
52.
53.
Calibration and non‐orthogonality correction of three‐axis Hall sensors for the monitoring of MRI workers' exposure to static magnetic fields 下载免费PDF全文
54.
Wormmeester Louktje; De Medina Fermin Sanchez; Kokke Freddy; Tse Chung-Ming; Khurana Seema; Bowser Joellyn; Cohen Michael E.; Donowitz Mark 《American journal of physiology. Cell physiology》1998,274(5):C1261
Intestinal neutral NaCl absorption, which is made up ofbrush-border (BB)Na+/H+exchange linked to BBCl/HCO3exchange, is up- and downregulated as part of digestion and diarrhealdiseases. Glucocorticoids stimulate ileal NaCl absorption and BBNa+/H+exchange. Intestinal BB contains twoNa+/H+exchanger isoforms, NHE2 and NHE3, but their relative roles in rabbitileal BBNa+/H+exchange has not been determined. A technique to separate the contribution of NHE2 and NHE3 to ileal BBNa+/H+exchange activity was standardized by using an amiloride-related compound, HOE-694. Under basal conditions, both NHE2 and NHE3 contribute ~50% to ilealNa+/H+exchange. Glucocorticoids (methylprednisolone) increase BBNa+/H+exchange (2.5 times) but increase only ileal NHE3 activity (4.1 times),without an effect on NHE2 activity. Thus ileal BBNa+/H+exchange in animals treated with glucocorticoids is 69% via NHE3. Aquantitative Western analysis for NHE3 was developed, using as aninternal standard a fusion protein of the COOH-terminal 85 amino acidsof NHE3 and maltose binding protein. Glucocorticoid treatment increasedthe amount of BB NHE3. The quantitative Western analysis showed thatNHE3 makes up 0.018% of ileal BB protein in control rabbits and0.042% (2.3 times as much) in methylprednisolone-treated rabbits.Methylprednisolone treatment did not alter the amount of ileal BB NHE2protein. NHE3 turnover number was estimated to be 458 cycles/s underbasal conditions and 708 cycles/s in glucocorticoid-treated ileum. Thusmethylprednisolone stimulates ileal BBNa+/H+exchange activity only by an effect on NHE3 and not on NHE2; it does soprimarily by increasing the amount of BB NHE3, although it alsoincreases the NHE3 turnover number. 相似文献
55.
Historical Ecology on Sandoy, Faroe Islands: Palaeoenvironmental and Archaeological Perspectives 总被引:1,自引:1,他引:0
Ian T. Lawson Mike J. Church Tom H. McGovern Símun V. Arge James Woollet Kevin J. Edwards Freddy J. Gathorne-Hardy Andrew J. Dugmore Gordon Cook Kerry-Anne Mairs Amanda M. Thomson Guðrún Sveinbjarnardótti 《Human ecology: an interdisciplinary journal》2005,33(5):651-684
We present palaeoenvironmental, geomorphological, archaeological, and place-name data which allow a holistic assessment of
the history of landscape change on Sandoy, Faroe Islands, especially in terms of the changes that occurred in response to
the colonization of the island by humans. In contrast to other situations in the North Atlantic region, there is considerable
continuity in the patterns and processes of landscape evolution across the initial settlement horizon. Many of the characteristic
features of post-settlement North Atlantic landscapes—absence of trees, widespread blanket mires, high rates of soil erosion—were
already in place when the first people arrived. Although human impact on Sandoy appears to have been light, conversely, the
unusual environment forced major alterations of the subsistence economy imported by the colonists. Settlement-era archaeological
records suggest that, from the start, patterns of resource use differed substantially from the regional norm, and these differences
became amplified over time as the Faroese economy created a locally sustainable cultural landscape. 相似文献
56.
57.
Montoya-Lerma J Solarte YA Giraldo-Calderón GI Quiñones ML Ruiz-López F Wilkerson RC González R 《Memórias do Instituto Oswaldo Cruz》2011,106(Z1):223-238
Here we present a comprehensive review of the literature on the vectorial importance of the major Anopheles malaria vectors in Colombia. We provide basic information on the geographical distribution, altitudinal range, immature habitats, adult behaviour, feeding preferences and anthropophily, endophily and infectivity rates. We additionally review information on the life cycle, longevity and population fluctuation of Colombian Anopheles species. Emphasis was placed on the primary vectors that have been epidemiologically incriminated in malaria transmission: Anopheles darlingi, Anopheles albimanus and Anopheles nuneztovari. The role of a selection of local, regional or secondary vectors (e.g., Anopheles pseudopunctipennis and Anopheles neivai) is also discussed. We highlight the importance of combining biological, morphological and molecular data for the correct taxonomical determination of a given species, particularly for members of the species complexes. We likewise emphasise the importance of studying the bionomics of primary and secondary vectors along with an examination of the local conditions affecting the transmission of malaria. The presence and spread of the major vectors and the emergence of secondary species capable of transmitting human Plasmodia are of great interest. When selecting control measures, the anopheline diversity in the region must be considered. Variation in macroclimate conditions over a species' geographical range must be well understood and targeted to plan effective control measures based on the population dynamics of the local Anopheles species. 相似文献
58.
Intensive use of pesticides is common and increasing despite a growing and historically well documented awareness of the costs and hazards. The benefits from pesticides of increased yields from sufficient pest control may be outweighed by developed resistance in pests and killing of beneficial natural enemies. Other negative effects are human health problems and lower prices because of consumers' desire to buy organic products. Few studies have examined these trade-offs in the field. Here, we demonstrate that Nicaraguan cabbage (Brassica spp.) farmers may suffer economically by using insecticides as they get more damage by the main pest diamondback moth, Plutella xylostella (L.) (Lepidoptera: Plutellidae), at the same time as they spend economic resources on insecticides. Replicated similarly sized cabbage fields cultivated in a standardized manner were either treated with insecticides according common practice or not treated with insecticides over two seasons. Fields treated with insecticides suffered, compared with nontreated fields, equal or, at least in some periods of the seasons, higher diamondback moth pest attacks. These fields also had increased leaf damage on the harvested cabbage heads. Weight and size of the heads were not affected. The farmers received the same price on the local market irrespective of insecticide use. Rates of parasitized diamondback moth were consistently lower in the treated fields. Negative effects of using insecticides against diamondback moth were found for the density of parasitoids and generalist predatory wasps, and tended to affect spiders negatively. The observed increased leaf damages in insecticide-treated fields may be a combined consequence of insecticide resistance in the pest, and of lower predation and parasitization rates from naturally occurring predators that are suppressed by the insecticide applications. The results indicate biological control as a viable and economic alternative pest management strategy, something that may be particularly relevant for the production of cash crops in tropical countries where insecticide use is heavy and possibly increasing. 相似文献
59.
Moore MM Honma M Clements J Awogi T Douglas GR van Goethem F Gollapudi B Kimura A Muster W O'Donovan M Schoeny R Wakuri S 《Mutation research》2011,723(2):84-86
The Mouse Lymphoma Expert Workgroup of the International Workshop for Genotoxicity Tests (IWGT) met in Basel, Switzerland in August of 2009. The Workgroup (WG) was tasked with discussing the appropriate top concentration for non-pharmaceuticals that would be required for the conduct of the mouse lymphoma assay (MLA) when sufficient cytotoxicity [to between 10 and 20% relative total growth (RTG)] has not been attained. The WG approached this task by (1) enumerating the various regulatory decisions/use for MLA data, (2) discussing the appropriate assays to which MLA data and assay performance should be compared and (3) discussing all the proposals put forth concerning the top concentration for non-pharmaceuticals. In addition, one of the members presented a summary of a re-evaluation of the National Toxicology Program MLA data using the IWGT harmonized guidance that was underway as a separate (non IWGT) activity, being conducted by two members of the Expert WG. The WG was asked to vote on each of the various proposals for top concentration for when cytotoxicity is not concentration limiting. While there was general agreement that the top concentration for non-pharmaceuticals should be re-evaluated and likely lowered from the current recommended levels, there was no agreement on a specific new recommendation. 相似文献
60.
Marisol Aguirre Daisy M. A. E. Jonkers Freddy J. Troost Guus Roeselers Koen Venema 《PloS one》2014,9(11)
The aim of this study was to investigate the effect of galacto-oligosaccharides, lactulose, apple fiber and sugar beet pectin on the composition and activity of human colonic microbiota of lean and obese healthy subjects using an in vitro model of the proximal colon: TIM-2. Substrate fermentation was assessed by measuring the production of short-chain and branched-chain fatty acids, lactate and ammonia and by studying the composition of the bacterial communities over time. The results suggest that energy harvest (in terms of metabolites) of lean and obese microbiotas is different and may depend on the fermentable substrate. For galacto-oligosaccharides and lactulose, the cumulative amount of short-chain fatty acids plus lactate produced in TIM-2 was lower in the fermentation experiments with the lean microbiota (123 and 155 mmol, respectively) compared to the obese (162 and 173 mmol, respectively). This was reversed for the pectin and the fiber. The absolute amount produced of short-chain fatty acids including lactate was higher after 72 h in the fermentation experiments with apple fiber-L (108 mmol) than with apple fiber-O (92 mmol). Sugar beet-L was also higher (130 mmol) compared to sugar beet-O (103 mmol). Galacto-oligosaccharides and lactulose boosted the balance of health-promoting over toxic metabolites produced by the microbiota from obese subjects. Firmicutes were more predominant in the inoculum prepared from feces of obese subjects compared to lean subjects. The average abundance at time zero was 92% and 74%, respectively. On the other hand, Bacteroidetes were more dominant in the microbiota prepared with homogenates from lean subjects with an average abundance of 22% compared with the microbiota prepared with homogenates from obese subjects (3.6%). This study brings evidence that different fermentable carbohydrates are fermented differently by lean and obese microbiotas, which contributes to the understanding of the role of diet and the microbiota in tackling obesity. 相似文献