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Hilde Moyaert Frank Pasmans Annemie Decostere Richard Ducatelle & Freddy Haesebrouck 《FEMS immunology and medical microbiology》2009,57(1):14-16
Helicobacter equorum colonizes the caecum, colon and rectum of horses. The agent is highly prevalent in <6-month-old foals. In adult horses, the prevalence of H. equorum seems to be rather low, but these animals may harbour low, subdetectable numbers of this microorganism in their intestines. So far, no association could be made between the presence of H. equorum and clinical disease or intestinal lesions in adult horses. Further research is necessary to elucidate the pathogenic potential of this bacterial species towards young foals. Helicobacter equorum DNA was not detected in human faeces, indicating that this microorganism does not commonly spread from horses towards humans. 相似文献
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Freddy Bravo Hans Pohl Alberto Silva-Neto Rolf G. Beutel 《Cladistics : the international journal of the Willi Hennig Society》2009,25(6):614-623
An adult male of a newly discovered strepsipteran species from Brazil— Bahiaxenos relictus— is described. A new family Bahiaxenidae is suggested based on cladistic analyses of comprehensive morphological data sets with a broad taxon sampling including the stem group. It is unambiguously placed as the sister group of all other extant families of Strepsiptera. Bahiaxenos relictus is the only species of basal, i.e. non-stylopidian, Strepsiptera occurring in the New World. It appears to be a relict taxon that has survived in the fossil sand dunes of the São Francisco River (Bahia State). The loss of the 8th antennomere and the greatly reduced labrum are autapomorphies of Strepsiptera s.s . excluding Bahiaxenidae. The sister group relationship between†Protoxenidae and the remaining Strepsiptera, and between † Cretostylops and a clade comprising † Mengea and Strepsiptera s.s. , is confirmed, as is the monophyly of Stylopidia and Stylopiformia. 相似文献
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Caterina Collodet Jessica Sordet‐Dessimoz Maria Pilar Giner Stefan Christen Sofia Moco Marion Leleu Laurence de Leval Ute Koch Andreas Trumpp Kei Sakamoto Friedrich Beermann Freddy Radtke 《The EMBO journal》2018,37(5)
Although c‐Myc is essential for melanocyte development, its role in cutaneous melanoma, the most aggressive skin cancer, is only partly understood. Here we used the NrasQ61KINK4a?/? mouse melanoma model to show that c‐Myc is essential for tumor initiation, maintenance, and metastasis. c‐Myc‐expressing melanoma cells were preferentially found at metastatic sites, correlated with increased tumor aggressiveness and high tumor initiation potential. Abrogation of c‐Myc caused apoptosis in primary murine and human melanoma cells. Mechanistically, c‐Myc‐positive melanoma cells activated and became dependent on the metabolic energy sensor AMP‐activated protein kinase (AMPK), a metabolic checkpoint kinase that plays an important role in energy and redox homeostasis under stress conditions. AMPK pathway inhibition caused apoptosis of c‐Myc‐expressing melanoma cells, while AMPK activation protected against cell death of c‐Myc‐depleted melanoma cells through suppression of oxidative stress. Furthermore, TCGA database analysis of early‐stage human melanoma samples revealed an inverse correlation between C‐MYC and patient survival, suggesting that C‐MYC expression levels could serve as a prognostic marker for early‐stage disease. 相似文献
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