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Host larvae of Drosophila melanogaster injected with the eicosanoid biosynthesis inhibitor, dexamethasone, prior to parasitization by the wasp Leptopilina boulardi, exhibited significantly reduced rates of melanotic encapsulation in comparison with control and saline-injected larvae. The results of this investigation suggest that prostaglandins and other eicosanoids are involved as cell-signaling molecules in the hemocytic encapsulation reaction of D. melanogaster larvae. 相似文献
114.
An integrated linkage-radiation hybrid map of the canine genome 总被引:12,自引:0,他引:12
Cathryn S. Mellersh Christophe Hitte Melissa Richman Francoise Vignaux Catherine Priat Sophie Jouquand Petra Werner Catherine André Susan DeRose Donald F. Patterson Elaine A. Ostrander Francis Galibert 《Mammalian genome》2000,11(2):120-130
Purebred dogs are a unique resource for dissecting the molecular basis of simple and complex genetic diseases and traits.
As a result of strong selection for physical and behavioral characteristics among the 300 established breeds, modern dogs
are characterized by high levels of interbreed variation, complemented by significant intrabreed homogeneity. A high-resolution
map of the canine genome is necessary to exploit the mapping power of this unusual resource. We describe here the integration
of an expanded canine radiation hybrid map, comprised of 600 markers, with the latest linkage map of 341 markers, to generate
a map of 724 markers—the densest map of the canine genome described to date. Through the inclusion of 217 markers on both
the linkage and RH maps, the 77 RH groups are reduced to 44 syntenic groups, thus providing comprehensive coverage of most
of the canine genome.
Received: 10 June 1999 / Accepted: 23 September 1999 相似文献
115.
Correspondence analysis of HLA gene frequency data from 124 population samples. 总被引:3,自引:0,他引:3
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Correspondence analysis, a variant of principal components analysis, is used to interpret and compare gene frequencies of the HLA system for 124 samples from different populations studied in the Fifth and Sixth International Histocompatibility Workshops. The major advantage of this analysis is that populations and HLA genes are represented simultaneously with respect to the same axes in multidimensional space. This permits the visual interpretation of genetic differences between populations, the relative participation of each gene in the dispersion, and the correspondence between populations and genes. By this method a clear separation of ethnic groups in the world is obtained. Furthermore, within Europe the separation of samples from different countries is concordant with their geographical distances. The HLA system appears sufficiently polymorphic to define a population by its gene frequencies. 相似文献
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Delphine Delample Fabienne Durand Arnold Severac Monia Belghith Emilie Mas Francoise Michel 《Free radical research》2013,47(9):807-814
Objective: The aim of this study was to determine the implication of xanthine oxidase (XO) in the exercise-induced muscle oxidative stress and muscle dysfunction of these patients.Methods: A randomized, crossover and double-blind study was conducted in nine severe COPD patients, who performed a localized quadriceps endurance test after oral treatment with allopurinol, a XO inhibitor or placebo. Redox status was studied in arterial and venous femoral blood before and after the endurance test.Results: In placebo condition, muscle exercise resulted in a significant increase in AOPP and isoprostanes, with a significant increase in the venoarterial difference (v-a) in isoprostanes after exercise as compared with before (p<0.05). In contrast, allopurinol treatment prevented the elevation in AOPP levels and v-a isoprostanes after exercise. However, no significant improvement in quadriceps muscle endurance was observed, but allopurinol treatment seemed to preserve muscle strength properties.Conclusion: This study demonstrates that XO is implicated in the exercise-induced muscle oxidative stress of COPD patients. Allopurinol administration seemed to improve only some muscle properties. Therefore other sources of muscle oxidative stress should be implicated in muscle dysfunction observed in these patients. 相似文献
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Halley F Reinshagen J Ellinger B Wolf M Niles AL Evans NJ Kirkland TA Wagner JM Jung M Gribbon P Gul S 《Journal of biomolecular screening》2011,16(10):1227-1235
Histone deacetylase (HDAC) enzymes modify the acetylation state of histones and other important proteins. Aberrant HDAC enzyme function has been implicated in many diseases, and the discovery and development of drugs targeting these enzymes is becoming increasingly important. In this article, the authors report the evaluation of homogeneous, single-addition, bioluminogenic HDAC enzyme activity assays that offer less assay interference by compounds in comparison to fluorescence-based formats. The authors assessed the key operational assay properties including sensitivity, scalability, reproducibility, signal stability, robustness (Z'), DMSO tolerance, and pharmacological response to standard inhibitors against HDAC-1, HDAC-3/NcoR2, HDAC-6, and SIRT-1 enzymes. These assays were successfully miniaturized to a 10 μL assay volume, and their suitability for high-throughput screening was tested in validation experiments using 640 drugs approved by the Food and Drug Administration and the Hypha Discovery MycoDiverse natural products library, which is a collection of 10 049 extracts and fractions from fermentations of higher fungi and contains compounds that are of low molecular weight and wide chemical diversity. Both of these screening campaigns confirmed that the bioluminogenic assay was high-throughput screening compatible and yielded acceptable performance in confirmation, counter, and compound/extract and fraction concentration-response assays. 相似文献
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Todorova D Sabatier F Doria E Lyonnet L Vacher Coponat H Robert S Despoix N Legris T Moal V Loundou A Morange S Berland Y George FD Burtey S Paul P 《PloS one》2011,6(10):e26663