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11.
Elvira D'Alessandro Corinna De Matteis Vaccarella Maria Luisa Lo Re Francesco Cappa Angela D'Alfonso Stefania Discepoli Maria Rosa Della Penna Giuseppe Del Porto 《Human genetics》1988,80(2):203-204
Summary Pericentric inversion of chromosome 19 has been found in several members of three unrelated families from a restricted geographical region. In one of the families, an additional pericentric inversion of chromosome 9 was observed. Reproductive problems, multiple abortions in two families and a neonatal death in the third, were present. A review of previously described cases is included, and the genetic risk connected with this type of rearrangement is also discussed. 相似文献
12.
Most growth active hormones and peptides are mitogenic only in the presence of other growth factors [e.g., Platelet Derived Growth Factor (PDGF) and Epidermal Growth Factor (EGF) in "competence-progression" fibroblast model]. We have previously described that EGF alone is able to induce the signals which appear necessary for the mitogenic stimulation of EL2 rat embryo fibroblast line. Recently, we have demonstrated that Transforming Growth Factor beta (TGF beta) slightly stimulates the mitogenic response in EL2 cells. Here, we show that in EGF-treated EL2 cells the induction of at least four inducible-secreted proteins (ISPs, range from 29,000 to 68,000 Mr) is accompanied by a marked increase in DNA synthesis. In contrast, TGF beta or different concentrations of EGF induce a slow increase of the ISPs proportional to slow induction in DNA synthesis. Our results suggest that the mitogenic response in EL2 cell line may be connected with the qualitative and quantitative induction of these secreted proteins. 相似文献
13.
Summary The effects of positive and negative ions on man and on animals have been widely studied by numerous teams of researchers.
It is well-known that negative ions have beeeficial effects on chronic and allergy-related bronchopathies in man; they stimulate
the activity of the endocrine glands and psychomotor, muscular and cerebral functions. They have a beneficial effect on general
circulation, and in particular on the microcirculatory system, such that they are suggested for use in prophylaxis and prevention
of senescence, in acute, chronic and allergy-related pneumopathies, and in neuro-vegetative dystonia. The use of artificial
negative ion producers may be a useful tool for both preventive and therapeutic purposes, as well as hygienic/domestic applications.
Systematic measurements ere taken of negative ions artificially produced in a confined space. The spatial distribution of
artificially-produced negative ions in a confined space is presented. Applications relative to artificial generators are also
suggested in order to obtain repeatable experimental conditions. 相似文献
14.
Bianca Colonna Maria Bernardini Gioacchino Micheli Francesco Maimone Mauro Nicoletti Mariassunta Casalino 《Plasmid》1988,20(3):221-231
Tn1935, a 23.5-kb transposon mediating resistance to ampicillin, kanamycin, mercury, spectinomycin, and sulfonamide was isolated from pZM3, an IncFIme virulence plasmid from Salmonella wien. Tn1935 possesses the entire sequence of Tn21 and contains two additional DNA segments of 0.95 and 2.7 kb carrying the ampicillin and kanamycin resistance genes, respectively. The latter is part of a composite element since it is flanked by two IS15-like insertion sequences (IS1936) in direct orientation. IS1936 is about 800 bp long and is closely related to IS15 delta, IS26, IS46, IS140, and IS176. Functional analysis of IS1936-mediated cointegrates shows that both insertion sequences are active and able to form cointegrates at the same frequency. Resolution of the cointegrates requires the presence of the host Rec system. The presence of the composite IS1936-element within Tn1935 supports the hypothesis that multidrug resistance transposons evolved by insertion of antibiotic determinants which are themselves transposable. 相似文献
15.
Development of tool use in a macaque and a gorilla 总被引:3,自引:0,他引:3
Francesco Natale Patrizia Poti' Giovanna Spinozzi 《Primates; journal of primatology》1988,29(3):413-416
The development of the capacity to use a stick as a tool was tested in a macaque (Macaca fuscata) and a gorilla (Gorilla gorilla gorilla) infants that had previously shown to be able to use strings and supports as dragging tools. Subjects were tested between
15 and 38 months of age. Different levels of competence between the subjects emerged over testing. The macaque developed a
stereotyped strategy to cope with the problem, only getting random successes, whilst the gorilla developed a flexible strategy
and revealed to be able to mentally represent the solution of the problem. In fact, when not successful using the stick, the
gorilla thought out an alternative strategy, choosing and adapting a new object to use it as a tool. 相似文献
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18.
Gianluigi Discalzi Francesco Furno Luigi Gagliardi Mario Ambroso Jacqueline Mavro 《Aerobiologia》1992,8(1):62-68
Summary The purpose of this study is to verify and assess, in working conditions, the respiratory exposure to PPD of hairdressing parlour personnel. Several air samples collected in a hairdressing parlour during the time required for 8 applications of dyeing products containing PPD 2.52% have been analyzed. Tests are also carried out by extracting air immediately above the bowls containing the dyeing products, both at room temperature and at 37°C. PPD was assessed by means of HPLC. Only air sampled directly on bowls at 37°C has shown a level of 1 g, corresponding to an environmental release of PPD equivalent to 8 applications of dyeing products. On the basis of these experimental data, the PPD concentration in the air according to the parlour volume and to the supposed air exchanges has been calculated. Our results show a substantial insignificance of the concentration of PPD released in the environmental air during normal operations of hair dyeing: authors are of the opinion that hairdressers can't be truly considered as a PPD-asthmatic risk category like other workers exposed to PPD dust dispersed in the air of their working environment. 相似文献
19.
Giuseppe Frenguelli Emma Bricchi Bruno Romano Gianfranco Mincigrucci Francesco Ferranti Evasio Antognozzi 《Aerobiologia》1992,8(3):415-418
Summary 7 years of airborne pollen monitoring in Perugia (central Italy) were used to determine the temperature requirements to break dormancy and to resume growth and bloom ofCorylus avellana L.,Corylus needs 1000 chill-units to complete its dormancy and this value, in the Perugian area, is met by the end of December or the first days of January. MoreoverCorylus trees require 220 growth degree hours before they are able to flower. If air temperature is high, this value can be achieved in only 10 days, but if the temperature remains too low, the heat accumulation can require up to 35 days. With these parameters it is possible to build a model to predict the date of the beginning ofCorylus avellana pollen season. 相似文献
20.
Silvio De Flora Francesco D'Agostini Alberto Izzotti Roumen Balansky 《Mutation research》1991,250(1-2):87-93
The daily i.t. administration of benzo[a]pyrene (BP) to Sprague-Dawley rats, for 3 consecutive days, did not cause any toxicity or clastogenicity in bone marrow cells, as evaluated by monitoring the ratio of polychromatic to normochromatic erythrocytes and the frequency of micronucleated polychromatic erythrocytes. However, BP produced a considerable enhancement of binucleated and micronucleated pulmonary alveolar macrophages, as well as a significant increase in polymorphonucleates recovered by bronchoalveolar lavage. These effects were prevented by administering the thiol N-acetylcysteine (NAC) by gavage 5 h before each BP instillation. In addition, the i.t. treatment with BP resulted in the formation of BP diolepoxide (BPDE)-DNA adducts in lungs and liver, as assessed by synchronous fluorescence spectrophotometry, with fluorescence peaks of similar magnitude in the 2 tissues. Pretreatment with NAC by gavage completely prevented BPDE adducts to liver DNA and significantly decreased those to lung DNA. 相似文献