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排序方式: 共有407条查询结果,搜索用时 15 毫秒
401.
Gustavo R. Sarria Miguel Ángel Berenguer Francés Isabel Linares Galiana 《Reports of Practical Oncology and Radiotherapy》2019,24(1):65-67
Amongst all efforts for improving oncological management outcomes, nanoparticles enhanced radiation for breast cancer patient's treatment is a novel approach that has grown interest for research in the last decade. Multiple preclinical data has been published, from all around the globe; however, clinical evidence is still insufficient for implementing the method in routine practice and in disease specific management. Gold nanoparticles (AuNP), which may be among the most studed materials, account for the majority of available data; however, some new materials have also been used in preclinical settings.Without any safety data available at the moment to support an active use, dosimetric in vitro and in vivo information seems to be consistent with a very promising and hopeful panorama for clinical applications. This review evaluates existing dosimetric data in breast cancer tissue, and a probable future impact in treatment choices and patient outcomes, as further investigation is required in a clinical setting. 相似文献
402.
403.
William Martin Katrin Henze Josef Kellermann Anke Flechner Claus Schnarrenberger 《Plant molecular biology》1996,30(4):795-805
Ribose-5-phosphate isomerase (RPI) catalyses the interconversion of ribose-5-phosphate and ribulose-5-phosphate in the reductive and oxidative pentose phosphate pathways in plants. RPI from spinach chloroplasts was purified and microsequenced. Via PCR with degenerate primers designed against microsequenced peptides, a hybridisation probe was obtained and used to isolate several cDNA clones which encode RPI. The nuclear-encoded 239 amino acid mature RPI subunit has a predicted size of 25.3 kDa and is translated as a cytosolic precursor possessing a 50 amino acid transit peptide. The processing site of the transit peptide was identified from protein sequence data. Spinach leaves possess only one type of homodimeric RPI enzyme which is localized in chloroplasts and is encoded by a single nuclear gene. Molecular characterization of RPI supports the view that a single amphibolic RPI enzyme functions in the oxidative and reductive pentose phosphate pathways of spinach plastids.Abbreviations RPI
ribose-5-phosphate isomerase
- OPPP
oxidative pentose phosphate pathway
- CNBr
cyanogen bromide
- R5P
ribose-5-phosphate
- Ru5P
ribulose-5-phosphate 相似文献
404.
Rut Cañas Isabel Linares Ferran Guedea Miguel Ángel Berenguer Francés 《Reports of Practical Oncology and Radiotherapy》2019,24(1):60-64
Radiological Oncology, like the rest of medical specialties, is beginning to provide can personalized therapies. The ongoing scientific advances enable a great degree of precision in diagnoses and therapies. To fight cancer, from a radiotherapy unit, requires up-to-date equipment, professionals with different specialties working in synchrony (doctors, physicists, biologists, etc.) and a lot of research. Some of the new therapeutic tendencies are immunotherapy, nanoparticles, gene therapy, biomarkers, artificial intelligence, etc. A new clinical paradigm in which new professional networks are inevitable is arising. The mission of translational research is to become a scientific engine in the clinical space. 相似文献
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406.
E. Montesinos A. Bonaterra E. Badosa J. Francés J. Alemany I. Llorente C. Moragrega 《International microbiology》2002,5(4):169-175
Plants constitute an excellent ecosystem for microorganisms. The environmental conditions offered differ considerably between
the highly variable aerial plant part and the more stable root system. Microbes interact with plant tissues and cells with
different degrees of dependence. The most interesting from the microbial ecology point of view, however, are specific interactions
developed by plant-beneficial (either non-symbiotic or symbiotic) and pathogenic microorganisms. Plants, like humans and other
animals, also become sick, but they have evolved a sophisticated defense response against microbes, based on a combination
of constitutive and inducible responses which can be localized or spread throughout plant organs and tissues. The response
is mediated by several messenger molecules that activate pathogen-responsive genes coding for enzymes or antimicrobial compounds,
and produces less sophisticated and specific compounds than immunoglobulins in animals. However, the response specifically
detects intracellularly a type of protein of the pathogen based on a gene-for-gene interaction recognition system, triggering
a biochemical attack and programmed cell death. Several implications for the management of plant diseases are derived from
knowledge of the basis of the specificity of plant-bacteria interactions. New biotechnological products are currently being
developed based on stimulation of the plant defense response, and on the use of plant-beneficial bacteria for biological control
of plant diseases (biopesticides) and for plant growth promotion (biofertilizers).
Electronic Publication 相似文献
407.