Ending AIDS as a public health threat by 2030: Time to reset targets for 2025

Paul De Lay and co-authors introduce a Collection on the design of targets for ending the AIDS epidemic.     

Experimental study of different techniques for partial resection of the ovary]

The effects of leaving the ovarian cortex open after wedge resection were studied in a rabbit model. Twelve animals were operated: in one ovary the ovarian cortex was reattached with microsurgical sutures and in the contralateral it was left to heal by secondary intention. No significant differences were observed in adhesion formation and tissue reactivity between the two techniques. These data support the hypothesis that reattachment of the ovarian cortex is not necessary after conservative ovarian surgery and these findings could be useful in the laparoscopic treatment of benign ovarian pathology.     

Retinoic acid-binding protein: a plasma membrane component

Soluble protein extracts from lyophilized plasma membranes prepared from chick embryo skin and transplantable murine carcinomas were found to contain a specific retinoic acid-binding component. This binding component showed high affinity for biologically active analogs of retinoic acid. The plasma membrane component exhibited similar physicochemical properties to those of the retinoic acid-binding protein described earlier in the cytosol. The protein exhibited mercurial-sensitive thiol functions in ligand binding; the mercurial-inhibition was reversed on treatment with thiol compounds. The plasma membrane binding component may be involved in the cellular uptake of retinoic acid.