全文获取类型
收费全文 | 115篇 |
免费 | 6篇 |
出版年
2022年 | 1篇 |
2021年 | 3篇 |
2020年 | 4篇 |
2019年 | 1篇 |
2018年 | 1篇 |
2017年 | 2篇 |
2016年 | 1篇 |
2015年 | 3篇 |
2014年 | 2篇 |
2013年 | 5篇 |
2012年 | 5篇 |
2011年 | 5篇 |
2010年 | 5篇 |
2009年 | 5篇 |
2008年 | 8篇 |
2007年 | 7篇 |
2006年 | 8篇 |
2005年 | 7篇 |
2004年 | 2篇 |
2002年 | 2篇 |
2001年 | 1篇 |
2000年 | 5篇 |
1999年 | 3篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 3篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 2篇 |
1987年 | 1篇 |
1977年 | 1篇 |
1961年 | 1篇 |
1959年 | 1篇 |
1958年 | 1篇 |
1949年 | 1篇 |
1946年 | 1篇 |
1939年 | 2篇 |
1925年 | 2篇 |
1924年 | 6篇 |
排序方式: 共有121条查询结果,搜索用时 375 毫秒
31.
Activated p38gamma MAP kinase exhibited significant basal ATPase activity in the absence of a kinase substrate, and addition of a phosphoacceptor substrate increased k(cat)/K(m)20-fold. AMP-PCP was competitive with ATP binding and non-competitive with phosphoacceptor substrate binding. The nucleotide binding site affinity label 5'-(p-fluorosulfonylbenzoyl)adenosine (FSBA) bound stoichiometrically at Lys-56 in the ATP site of both unphosphorylated and activated p38gamma. AMP-PCP only protected the activated enzyme from FSBA inactivation, implying that AMP-PCP does not bind unphosphorylated p38gamma. Basal ATPase activities were also observed for activated p38alpha, ERK2 and JNK3 suggesting that the enzymatic mechanism may be similar for all classes of MAP kinases. 相似文献
32.
Thomas Riedel John F Fraser Kimble Dunster John Fitzgibbon Andreas Schibler 《Journal of applied physiology》2006,101(3):763-770
Smoke inhalation injuries are the leading cause of mortality from burn injury. Airway obstruction due to mucus plugging and bronchoconstriction can cause severe ventilation inhomogeneity and worsen hypoxia. Studies describing changes of viscoelastic characteristics of the lung after smoke inhalation are missing. We present results of a new smoke inhalation device in sheep and describe pathophysiological changes after smoke exposure. Fifteen female Merino ewes were anesthetized and intubated. Baseline data using electrical impedance tomography and multiple-breath inert-gas washout were obtained by measuring ventilation distribution, functional residual capacity, lung clearance index, dynamic compliance, and stress index. Ten sheep were exposed to standardized cotton smoke insufflations and five sheep to sham smoke insufflations. Measured carboxyhemoglobin before inhalation was 3.87 +/- 0.28% and 5 min after smoke was 61.5 +/- 2.1%, range 50-69.4% (P < 0.001). Two hours after smoke functional residual capacity decreased from 1,773 +/- 226 to 1,006 +/- 129 ml and lung clearance index increased from 10.4 +/- 0.4 to 14.2 +/- 0.9. Dynamic compliance decreased from 56.6 +/- 5.5 to 32.8 +/- 3.2 ml/cmH(2)O. Stress index increased from 0.994 +/- 0.009 to 1.081 +/- 0.011 (P < 0.01) (all means +/- SE, P < 0.05). Electrical impedance tomography showed a shift of ventilation from the dependent to the independent lung after smoke exposure. No significant change was seen in the sham group. Smoke inhalation caused immediate onset in pulmonary dysfunction and significant ventilation inhomogeneity. The smoke inhalation device as presented may be useful for interventional studies. 相似文献
33.
34.
Modeling the Circulation of a Disease Between Two Host Populations on non Coincident Spatial Domains
W.–-E.?Fitzgibbon M.?LanglaisEmail author F.?Marpeau J.-–J.?Morgan 《Biological invasions》2005,7(5):863-875
We derive a reaction–diffusion system modeling the spatial propagation of a disease with kinetics occurring on distinct spatial domains. This corresponds to the actual invasion of a disease from a species living in a given spatial domain toward a second species living in a different spatial domain. We study the global existence of solutions and discuss the long time behavior of solutions. Then we consider a special case, based on a model of brain worm infection from white-tailed deer to moose populations, for which we discuss the invasion success/failure process and disprove a conjecture stated in an earlier work. 相似文献
35.
36.
37.
Gibbon Fitzgibbon 《BMJ (Clinical research ed.)》1924,2(3333):927-928
38.
39.
Fitzgibbon ML Stolley MR Schiffer LA Braunschweig CL Gomez SL Van Horn L Dyer AR 《Obesity (Silver Spring, Md.)》2011,19(5):994-1003
The preschool years offer an opportunity to interrupt the trajectory toward obesity in black children. The Hip-Hop to Health Jr. Obesity Prevention Effectiveness Trial was a group-randomized controlled trial assessing the feasibility and effectiveness of a teacher-delivered weight control intervention for black preschool children. The 618 participating children were enrolled in 18 schools administered by the Chicago Public Schools. Children enrolled in the nine schools randomized to the intervention group received a 14-week weight control intervention delivered by their classroom teachers. Children in the nine control schools received a general health intervention. Height and weight, physical activity, screen time, and diet data were collected at baseline and postintervention. At postintervention, children in the intervention schools engaged in more moderate-to-vigorous physical activity (MVPA) than children in the control schools (difference between adjusted group means = 7.46 min/day, P = 0.02). Also, children in the intervention group had less total screen time (-27.8 min/day, P = 0.05). There were no significant differences in BMI, BMI Z score, or dietary intake. It is feasible to adapt an obesity prevention program to be taught by classroom teachers. The intervention showed positive influences on physical activity and screen time, but not on diet. Measuring diet and physical activity in preschool children remains a challenge, and interventions delivered by classroom teachers require both intensive initial training and ongoing individualized supervision. 相似文献
40.
Marian L. Fitzgibbon Melinda R. Stolley Linda Schiffer Angela Kong Carol L. Braunschweig Sandra L. Gomez‐Perez Angela Odoms‐Young Linda Van Horn Katherine Kaufer Christoffel Alan R. Dyer 《Obesity (Silver Spring, Md.)》2013,21(2):274-283