Fisher's Axiom and the Body Size of Animals

What is here called Fisher's axiom states that all large mutations are deleterious, and the consequence of this is the generally accepted Darwinian notion that all evolutionary progress must have occurred through the accumulation of small mutational steps. We have in the present paper tested the postulate that one parameter, namely, the body size (weight or volume) does not vary in this way, but rather in steps which are powers of two, up to or down, as the case may be. The outcome of our analysis is that this hypothesis is corroborated with fair significance for certain, randomly selected, groups of living and extinct animals. The consequences of this observation are briefly discussed.     

Validation and Calibration of Physical Activity Monitors in Children

Objective: This study was designed to validate accelerometer-based activity monitors against energy expenditure (EE) in children; to compare monitor placement sites; to field-test the monitors; and to establish sedentary, light, moderate, and vigorous threshold counts. Research Methods and Procedures: Computer Science and Applications Actigraph (CSA) and Mini-Mitter Actiwatch (MM) monitors, on the hip or lower leg, were validated and calibrated against 6-hour EE measurements by room respiration calorimetry, activity by microwave detector, and heart rate by telemetry in 26 children, 6 to 16 years old. During the 6 hours, the children performed structured activities, including resting metabolic rate (RMR), Nintendo, arts and crafts, aerobic warm-up, Tae Bo, treadmill walking and running, and games. Activity energy expenditure (AEE) computed as EE − RMR was regressed against counts to derive threshold counts. Results: The mean correlations between EE or AEE and counts were slightly higher for MM-hip (r = 0.78 ± 0.06) and MM-leg (r = 0.80 ± 0.05) than CSA-hip (r = 0.66 ± 0.08) and CSA-leg (r = 0.73 ± 0.07). CSA and MM performed similarly on the hip (inter-instrument r = 0.88) and on the lower leg (inter-instrument r = 0.89). Threshold counts for the CSA-hip were <800, <3200, <8200, and ≥8200 for sedentary, light, moderate, and vigorous categories, respectively. For the MM-hip, the threshold counts were <100, <900, <2200, and ≥2200, respectively. Discussion: The validation of the CSA and MM monitors against AEE and their calibration for sedentary, light, moderate, and vigorous thresholds certify these monitors as valid, useful devices for the assessment of physical activity in children.     

Preparative scale enantioseparation of a chiral epoxide: Comparison of liquid chromatography and simulated moving bed adsorption technology

The feasibility of using simulated moving bed technology (SMB) for chiral separation on cellulose triacetate is demonstrated on the preparative scale: 1 kg of a chiral epoxide has been separated. On comparing SMB technology with conventional liquid chromatography it turns out that the main advantage of SMB lies in the significant reduction of mobile phase consumption. The process design for SMB is made theoretically and the predictions are confirmed by our pilot study. © 1993 Wiley-Liss, Inc.