全文获取类型
收费全文 | 2479篇 |
免费 | 186篇 |
国内免费 | 1篇 |
专业分类
2666篇 |
出版年
2023年 | 6篇 |
2022年 | 38篇 |
2021年 | 64篇 |
2020年 | 31篇 |
2019年 | 40篇 |
2018年 | 53篇 |
2017年 | 37篇 |
2016年 | 64篇 |
2015年 | 115篇 |
2014年 | 109篇 |
2013年 | 156篇 |
2012年 | 181篇 |
2011年 | 191篇 |
2010年 | 138篇 |
2009年 | 115篇 |
2008年 | 176篇 |
2007年 | 154篇 |
2006年 | 152篇 |
2005年 | 159篇 |
2004年 | 115篇 |
2003年 | 125篇 |
2002年 | 110篇 |
2001年 | 25篇 |
2000年 | 24篇 |
1999年 | 25篇 |
1998年 | 34篇 |
1997年 | 19篇 |
1996年 | 18篇 |
1995年 | 9篇 |
1994年 | 15篇 |
1993年 | 11篇 |
1992年 | 12篇 |
1991年 | 5篇 |
1990年 | 18篇 |
1989年 | 7篇 |
1988年 | 13篇 |
1987年 | 11篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 14篇 |
1983年 | 5篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1978年 | 5篇 |
1977年 | 4篇 |
1976年 | 8篇 |
1975年 | 5篇 |
1972年 | 7篇 |
1970年 | 4篇 |
1969年 | 4篇 |
排序方式: 共有2666条查询结果,搜索用时 15 毫秒
51.
52.
Rosanna Pescini Gobert Monique van den Eijnden Cedric Szyndralewiez Catherine Jorand-Lebrun Dominique Swinnen Linfeng Chen Corine Gillieron Fiona Pixley Pierre Juillard Patrick Gerber Caroline Johnson-L��ger Serge Halazy Montserrat Camps Agnes Bombrun Margaret Shipp Pierre-Alain Vitte Vittoria Ardissone Chiara Ferrandi Dominique Perrin Christian Rommel Rob Hooft van Huijsduijnen 《The Journal of biological chemistry》2009,284(17):11385-11395
53.
Ellingsgaard H Hauselmann I Schuler B Habib AM Baggio LL Meier DT Eppler E Bouzakri K Wueest S Muller YD Hansen AM Reinecke M Konrad D Gassmann M Reimann F Halban PA Gromada J Drucker DJ Gribble FM Ehses JA Donath MY 《Nature medicine》2011,17(11):1481-1489
Exercise, obesity and type 2 diabetes are associated with elevated plasma concentrations of interleukin-6 (IL-6). Glucagon-like peptide-1 (GLP-1) is a hormone that induces insulin secretion. Here we show that administration of IL-6 or elevated IL-6 concentrations in response to exercise stimulate GLP-1 secretion from intestinal L cells and pancreatic alpha cells, improving insulin secretion and glycemia. IL-6 increased GLP-1 production from alpha cells through increased proglucagon (which is encoded by GCG) and prohormone convertase 1/3 expression. In models of type 2 diabetes, the beneficial effects of IL-6 were maintained, and IL-6 neutralization resulted in further elevation of glycemia and reduced pancreatic GLP-1. Hence, IL-6 mediates crosstalk between insulin-sensitive tissues, intestinal L cells and pancreatic islets to adapt to changes in insulin demand. This previously unidentified endocrine loop implicates IL-6 in the regulation of insulin secretion and suggests that drugs modulating this loop may be useful in type 2 diabetes. 相似文献
54.
Leonard H Glasson E Nassar N Whitehouse A Bebbington A Bourke J Jacoby P Dixon G Malacova E Bower C Stanley F 《PloS one》2011,6(3):e17875
Background
Research findings investigating the sociodemographics of autism spectrum disorder (ASD) have been inconsistent and rarely considered the presence of intellectual disability (ID).Methods
We used population data on Western Australian singletons born from 1984 to 1999 (n = 398,353) to examine the sociodemographic characteristics of children diagnosed with ASD with or without ID, or ID without ASD compared with non-affected children.Results
The profiles for the four categories examined, mild-moderate ID, severe ID, ASD without ID and ASD with ID varied considerably and we often identified a gradient effect where the risk factors for mild-moderate ID and ASD without ID were at opposite extremes while those for ASD with ID were intermediary. This was demonstrated clearly with increased odds of ASD without ID amongst older mothers aged 35 years and over (odds ratio (OR) = 1.69 [CI: 1.18, 2.43]), first born infants (OR = 2.78; [CI: 1.67, 4.54]), male infants (OR = 6.57 [CI: 4.87, 8.87]) and increasing socioeconomic advantage. In contrast, mild-moderate ID was associated with younger mothers aged less than 20 years (OR = 1.88 [CI: 1.57, 2.25]), paternal age greater than 40 years (OR = 1.59 [CI: 1.36, 1.86]), Australian-born and Aboriginal mothers (OR = 1.60 [CI: 1.41, 1.82]), increasing birth order and increasing social disadvantage (OR = 2.56 [CI: 2.27, 2.97]). Mothers of infants residing in regional or remote areas had consistently lower risk of ASD or ID and may be linked to reduced access to services or under-ascertainment rather than a protective effect of location.Conclusions
The different risk profiles observed between groups may be related to aetiological differences or ascertainment factors or both. Untangling these pathways is challenging but an urgent public health priority in view of the supposed autism epidemic. 相似文献55.
56.
The proliferative response of the mouse bladder was investigated, using continuous labelling with tritiated thymidine, at various times after a single dose of radiation. Bladder epithelial and vascular endothelial cells were studied. The cell turnover rate in unirradiated epithelium and endothelium was found to be extremely slow (in excess of 1 year). Irradiation with a single dose of 25 Gy resulted in compensatory proliferation of the epithelium but the response was not initiated for many months. At 3 months after irradiation there was little difference from the control proliferation rate, but from 6 to 22 months after irradiation (the end of the study) there was a period of sustained rapid proliferation with the cell turnover time reduced to approximately 1 week. The increase in proliferative activity observed at 22 months was found to be dose—dependent. Endothelial cells in the blood vessels of the submucosa also showed an increased turnover rate after irradiation and the timing of this reponse was found to be similar to that of the epithelium. The onset of compensatory proliferation in both cell types was found to coincide with marked histological and functional changes in the bladder. In this slowly proliferating tissue, the onset of rapid compensatory proliferation after irradiation is delayed and occurs at the time that functional impairment is observed. This supports the postulate that proliferation is unlikely to contribute much to the sparing effect of prolonged fractionated radiotherapy in slowly dividing tissues. 相似文献
57.
58.
59.
60.
Nahla V Bassil Thomas M Davis Hailong Zhang Stephen Ficklin Mike Mittmann Teresa Webster Lise Mahoney David Wood Elisabeth S Alperin Umesh R Rosyara Herma Koehorst-vanc Putten Amparo Monfort Daniel J Sargent Iraida Amaya Beatrice Denoyes Luca Bianco Thijs van Dijk Ali Pirani Amy Iezzoni Dorrie Main Cameron Peace Yilong Yang Vance Whitaker Sujeet Verma Laurent Bellon Fiona Brew Raul Herrera Eric van de Weg 《BMC genomics》2015,16(1)