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排序方式: 共有978条查询结果,搜索用时 15 毫秒
961.
962.
Katerina Juzlova Filip Rob Hana Zakoucka Andrea Kubatova Zuzana Secnikova Martina Krasova Petr Bohac Jana Hercogova 《Folia microbiologica》2018,63(1):93-95
We are reporting the first case of lymphogranuloma venereum in women in East-Central Europe. A 22-year-old heterosexual woman attended our department of venereology. She complained about a burning sensation in the urethra and vaginal discharge. Many tests were performed, and lymphogranuloma venereum, syphilis, gonorrhea, chlamydial urethritis and cervicitis, genital herpes, genital warts, and hepatitis C were diagnosed. Lymphogranuloma venereum was originally endemic in tropical and subtropical areas, but since 2003, outbreaks of this infection have been reported in North America, Europe, and Australia in men who have sex with men (MSM) community. To date, all cases of lymphogranuloma venereum in the Czech Republic appeared in men, predominantly in HIV-positive MSM. There are not many evidences about lymphogranuloma venereum (LGV) in women in developed countries. This report underlines the need for awareness of lymphogranuloma venereum in women among gynecologists, venereologists, and other physicians not only in Western Europe, but across all European countries. 相似文献
963.
The Impact of Water Content and Mixing Time on the Linear and Non-Linear Rheology of Wheat Flour Dough 总被引:1,自引:0,他引:1
Mathieu Meerts Ruth Cardinaels Filip Oosterlinck Christophe M. Courtin Paula Moldenaers 《Food biophysics》2017,12(2):151-163
The viscoelastic properties of wheat flour dough are known to be very sensitive to small changes in water content and mixing time. In this study the simple scaling law originally proposed by Hibberd (1970) [Rheol. Acta 9, 497-500] to capture the water dependency of the dynamic moduli in small amplitude oscillatory shear, was also applied to creep-recovery shear tests and extensional tests. The scaling law turns out to be valid not only in the linear region, but to a certain extent also in the non-linear region. At sufficiently high water levels, a ‘free’ water phase exists in dough, which attenuates the starch-starch and gluten-starch interactions. Dough characterisation after different mixing times shows that overmixing may cause a disaggregation or even depolymerisation of the gluten network. The network breakdown, as well as the subsequent (partial) recovery, are clearly reflected in the value of the strain-hardening index, for which a maximum is reached at a mixing time close to the optimum as determined with the Mixograph. Finally, the gluten proteins turn out to be much less susceptible to overmixing in an oxygen-lean environment, which demonstrates the significant role of oxygen in the degradation process. 相似文献
964.
965.
Jiri Soukup Helena Hornychova Monika Manethova Kvetoslava Michalova Ludmila Michnova Lenka Popovska Veronika Skarkova Tomas Cesak David Netuka Ales Ryska Jan Cap Václav Hána Václav Hána Jr Michal Kršek Eva Dvořáková Michal Krčma Ivica Lazurova Věra Olšovská Karel Starý Peter Vaňuga Filip Gabalec 《Journal of cellular and molecular medicine》2021,25(5):2484-2492
In somatotroph pituitary tumours, somatostatin analogue (SSA) therapy outcomes vary throughout the studies. We performed an analysis of cohort of patients with acromegaly from the Czech registry to identify new prognostic and predictive factors. Clinical data of patients were collected, and complex immunohistochemical assessment of tumour samples was performed (SSTR1-5, dopamine D2 receptor, E-cadherin, AIP). The study included 110 patients. In 31, SSA treatment outcome was evaluated. Sparsely granulated tumours (SGST) differed from the other subtypes in expression of SSTR2A, SSTR3, SSTR5 and E-cadherin and occurred more often in young. No other clinical differences were observed. Trouillas grading system showed association with age, tumour size and SSTR2A expression. Factors significantly associated with SSA treatment outcome included age, IGF1 levels, tumour size and expression of E-cadherin and SSTR2A. In the group of SGST, poor SSA response was observed in younger patients with larger tumours, lower levels of SSTR2A and higher Ki67. We observed no relationship with expression of other proteins including AIP. No predictive value of E-cadherin was observed when tumour subtype was considered . Multiple additional factors apart from SSTR2A expression can predict treatment outcome in patients with acromegaly. 相似文献
966.
967.
Mikael Flockhart Lina C. Nilsson Senna Tais Björn Ekblom William Apró Filip J. Larsen 《Cell metabolism》2021,33(5):957-970.e6
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968.
Karim Si-Tayeb Fallon K Noto Ana Sepac Filip Sedlic Zeljko J Bosnjak John W Lough Stephen A Duncan 《BMC developmental biology》2010,10(1):81
Background
The use of lentiviruses to reprogram human somatic cells into induced pluripotent stem (iPS) cells could limit their therapeutic usefulness due to the integration of viral DNA sequences into the genome of the recipient cell. Recent work has demonstrated that human iPS cells can be generated using episomal plasmids, excisable transposons, adeno or sendai viruses, mRNA, or recombinant proteins. While these approaches offer an advance, the protocols have some drawbacks. Commonly the procedures require either subcloning to identify human iPS cells that are free of exogenous DNA, a knowledge of virology and safe handling procedures, or a detailed understanding of protein biochemistry. 相似文献969.
Maes Lauranne Vervenne Thibault Van Hoof Lucas Jones Elizabeth A. V. Rega Filip Famaey Nele 《Biomechanics and modeling in mechanobiology》2023,22(5):1555-1568
Biomechanics and Modeling in Mechanobiology - The pulmonary autograft in the Ross procedure, where the aortic valve is replaced by the patient’s own pulmonary valve, is prone to failure due... 相似文献
970.
D A Filip 《Morphologie et embryologie》1984,30(3):165-173
Morphometric data on mouse atrio-ventricular valve ultrastructure are reported. The statistical analysis of the volumetric density percentage for cellular and extracellular valve components and of endothelial plasmalemmal vesicle density for the different endocardial domains (atrial, valvular and ventricular) showed: the bicuspid compared to the tricuspid valve has a more important lymphatic drainage, less vascularization, higher endothelial plasmalemmal vesicle density and more macrophages, striated muscle cells and collagen along with fewer interstitial cells, nervous terminals and elastin in the leaflet; the valvular endothelium as compared to other endocardial domains has a higher density of plasmalemmal vesicles, considering the results for both endothelial fronts (luminal and abluminal). 相似文献