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241.
Abdulahad DA Westra J Bijzet J Limburg PC Kallenberg CG Bijl M 《Arthritis research & therapy》2011,13(3):R71
Introduction
High Mobility Group Box 1 (HMGB1) is a nuclear non-histone protein. HMGB1, which is secreted by inflammatory cells and passively released from apoptotic and necrotic cells, may act as a pro-inflammatory mediator. As apoptotic cells accumulate in systemic lupus erythematosus (SLE), HMGB1 levels might be increased in SLE. HMGB1 may also serve as an autoantigen, leading to the production of anti-HMGB1 antibodies. In this study we determined levels of HMGB1 and anti-HMGB1 in SLE patients in comparison to healthy controls (HC) and analysed their relation with disease activity. 相似文献242.
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Costa Leonardo Lopes Arueira Vitor Figueira Ocaa Frank A. Soares-Gomes Abilio Zalmon Ilana Rosental 《Hydrobiologia》2022,849(15):3287-3298
Hydrobiologia - Testing ghost crabs as indicator species usually fail to depict the mechanisms behind low burrow densities in urban coasts, neglecting individual traits as diagnostic variables. We... 相似文献
244.
Glyn-Mara Figueira Ange-Marie Risterucci Maria Imaculada Zucchi Marcelo Mattos Cavallari Jean-Louis Noyer 《Conservation Genetics》2010,11(3):1127-1129
Cordia verbenacea DC (Boraginaceae) is a Brazilian coastal shrub species extensively utilized in the folk medicine and also by the pharmaceutical
industry. Despite its enormous economic and pharmacological potential, little is known about its reproductive biology, genetic
structure and genetic diversity of natural populations. Due to the rapid degradation of its natural habitat, this knowledge
became imperative. We developed a set of eight highly polymorphic microsatellite markers for the study of genetic structure
and diversity of C. verbenacea natural populations and germplasm collections. Six of them revealed a multibanded pattern typical of polyploid species. The
total number of bands per locus ranged from 2 to 12 and the number of bands per locus per individual ranged from 1 to 8. The
primer pairs presented here will be used to generate information to guide conservation programs and rational exploitation
of C. verbenacea. 相似文献
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Cyclic adenosine monophosphate normally stimulates motility of spermatozoa. Its concentration in cervical mucus was studied by an isotopic competitive method in 15 normal women aged between 20 and 50 years. Values were very high, particularly in the periovulatory period, with a mean (+/-SD) value of 167.90 +/- 154.96 nmol/l. These are very high when compared with values in other biological fluids (blood serum and urine). 相似文献
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Sérgio Luiz Borges de Souza Gustavo Augusto Ferreira Mota Vitor Loureiro da Silva Danielle Fernandes Vileigas Paula Grippa Sant'Ana Cristina Schmitt Gregolin Rebeca Lopes Figueira Sabrina Setembre Batah Alexandre Todorovic Fabro Gilson Masahiro Murata Silmeia Garcia Zanati Bazan Marina Politi Okoshi Antonio Carlos Cicogna 《Journal of cellular and molecular medicine》2023,27(19):2956-2969
We employed an early training exercise program, immediately after recovery from surgery, and before severe cardiac hypertrophy, to study the underlying mechanism involved with the amelioration of cardiac dysfunction in aortic stenosis (AS) rats. As ET induces angiogenesis and oxygen support, we aimed to verify the effect of exercise on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS and trained AS (AST). The exercise consisted of 5-week sessions of treadmill running for 16 weeks. Statistical analysis was conducted by anova or Kruskal–Wallis test and Goodman test. A global correlation between variables was also performed using a two-tailed Pearson's correlation test. AST rats displayed a higher functional capacity and a lower cardiac remodelling and dysfunction when compared to AS, as well as the myocardial capillary rarefaction was prevented. Regarding metabolic properties, immunoblotting and enzymatic assay raised beneficial effects of exercise on fatty acid transport and oxidation pathways. The correlation assessment indicated a positive correlation between variables of angiogenesis and FA utilisation, as well as between metabolism and echocardiographic parameters. In conclusion, early exercise improves exercise tolerance and attenuates cardiac structural and functional remodelling. In parallel, exercise attenuated myocardial capillary and lipid metabolism derangement in rats with aortic stenosis-induced heart failure. 相似文献