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Nathalia Vitureira Rosa Andrés Esther Pérez-Martínez Albert Martínez Ana Bribián Juan Blasi Shierley Chelliah Guillermo López-Doménech Fernando De Castro Ferran Burgaya Kelly McNagny Eduardo Soriano 《PloS one》2010,5(8)
Neural development and plasticity are regulated by neural adhesion proteins, including the polysialylated form of NCAM (PSA-NCAM). Podocalyxin (PC) is a renal PSA-containing protein that has been reported to function as an anti-adhesin in kidney podocytes. Here we show that PC is widely expressed in neurons during neural development. Neural PC interacts with the ERM protein family, and with NHERF1/2 and RhoA/G. Experiments in vitro and phenotypic analyses of podxl-deficient mice indicate that PC is involved in neurite growth, branching and axonal fasciculation, and that PC loss-of-function reduces the number of synapses in the CNS and in the neuromuscular system. We also show that whereas some of the brain PC functions require PSA, others depend on PC per se. Our results show that PC, the second highly sialylated neural adhesion protein, plays multiple roles in neural development. 相似文献
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Ferran Garcia-Pichel Jonathan P. Zehr Debashish Bhattacharya Himadri B. Pakrasi 《Journal of phycology》2020,56(1):1-5
A redefinition of the cyanobacterial lineage has been proposed based on phylogenomic analysis of distantly related nonphototrophic lineages. We define Cyanobacteria here as “Organisms in the domain bacteria able to carry out oxygenic photosynthesis with water as an electron donor and to reduce carbon dioxide as a source of carbon, or those secondarily evolved from such organisms.” 相似文献
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Daniel Sol Ferran Sayol Simon Ducatez Louis Lefebvre 《Philosophical transactions of the Royal Society of London. Series B, Biological sciences》2016,371(1690)
The evolutionary origin of innovativeness remains puzzling because innovating means responding to novel or unusual problems and hence is unlikely to be selected by itself. A plausible alternative is considering innovativeness as a co-opted product of traits that have evolved for other functions yet together predispose individuals to solve problems by adopting novel behaviours. However, this raises the question of why these adaptations should evolve together in an animal. Here, we develop the argument that the adaptations enabling animals to innovate evolve together because they are jointly part of a life-history strategy for coping with environmental changes. In support of this claim, we present comparative evidence showing that in birds, (i) innovative propensity is linked to life histories that prioritize future over current reproduction, (ii) the link is in part explained by differences in brain size, and (iii) innovative propensity and life-history traits may evolve together in generalist species that frequently expose themselves to novel or unusual conditions. Combined with previous evidence, these findings suggest that innovativeness is not a specialized adaptation but more likely part of a broader general adaptive system to cope with changes in the environment. 相似文献
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J. Pizzol O. Khoualdia A. Ferran P. Chavigny F. Vanlerberghe-Masutti 《Biocontrol Science and Technology》2005,15(5):527-531
A single microsatellite marker was used to distinguish between strains of Trichogramma cacoeciae Marchal collected from the carob moth (Ectomyelois ceratoniae) in Tunisia and from the grapevine moth (Lobesia botrana) and a hawk moth in France. This marker can be used as an identification and monitoring tool in pest management programs. 相似文献
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