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81.
Peter N. Ferns & Alison Lang 《Ethology : formerly Zeitschrift fur Tierpsychologie》2003,109(6):521-532
Immaculateness, a novel measure of bird plumage quality, defined as the regularity of the borders of a coloured patch of feathers, and the uniformity of the colour within the patch, tends to decline as a result of feather wear and damage. If it declines more quickly amongst birds in poor condition, it has the potential to act as an honest signal of individual quality and therefore be subject to social and sexual selection. We scored plumage immaculateness in shelducks Tadorna tadorna, based on the absence of white feathers in the red-brown chest band and the evenness of the band's border. We monitored body condition and plumage quality in birds at feeding sites in the Severn Estuary (UK) during the early breeding season when females were forming eggs, and later in the season when chicks arrived. Drakes had more immaculate chest bands than ducks. At preferred feeding sites, drakes were more immaculate, and birds of both sexes were in better body condition. Birds with more immaculate plumage tended to mate assortatively at preferred sites and were more likely to produce a brood that survived the journey to the feeding areas. Immaculateness could therefore be an honest signal of parental quality. Although our evidence is only correlational, we suggest that plumage immaculateness indicates the ability to establish and maintain control over the best breeding sites and feeding territories in the face of competition with other shelducks. 相似文献
82.
Sima Seifi Farzaneh Pouya Mahsa Rahmani Mehrane Mehramiz Azam Rastgar-Moghadam Masoumeh Gharib Farzad Rahmani Soodabeh Shahidsales Seyed Mahdi Hassanian Majid Khazaei Parisa Dadjoo Seyede Sara Parvin Yeganeh yazdinezhad Seyed Mohammad Reza Parizadeh Gordon A. Ferns Mehdi Fathi Amir Avan 《Journal of cellular physiology》2020,235(6):5141-5145
There is a growing body of data reporting the association of genetic alterations in chromosome 9P21 with the risk of developing cancer. In the current study, we studied the association of a genetic variant in CDKN2A/B, rs1333049, with the risk of developing breast cancer. A total of 339 participants with and without breast cancer entered to the study. Genotyping was done by the TaqMan real-time polymerase chain reaction (RT-PCR) method and gene expression analysis was ran by RT-PCR. Our data showed that the minor allele homozygote in the total population was 10%, whereas for heterozygote was 38%. The dominant genetic model demonstrated that individuals with breast cancer had advanced TNM classification. Moreover, the logistic regression revealed that individuals who had CC/CG genotypes might have an enhanced risk of developing breast cancer when compared to the holders of GG genotype (e.g., OR = 2.8; 95% CI,1.4–5.4; p = .001), after regulated for confounders; age and body mass index. Furthermore, our analysis showed that the CDKN2A/B gene was downregulated in patients (p < .001). We showed a meaningful relationship of CDKN2A/B with the risk of breast cancer, cancer, showing the importance of studies in great sample size and several centers for studying the value of the marker as a risk classification in the management of patients with breast cancer. 相似文献
83.
Egg maturation strategy and its associated trade-offs: a synthesis focusing on Lepidoptera 总被引:10,自引:0,他引:10
Abstract. 1. Insects vary considerably between and within orders, and even within the same genus, in the degree to which the female's lifetime potential egg complement is mature when she emerges as an adult. 2. The ‘ovigeny index’ (OI) – the number of eggs females have ready to lay divided by the lifetime potential fecundity – quantifies variation in the degree of early life concentration of egg production, and also variation in initial reproductive effort. 3. Here, an integrated set of hypotheses is presented, based on a conceptual model of resource allocation and acquisition, concerning trade‐offs at the interspecific level between initial investment in egg production (as measured by OI) and other life‐history traits in holometabolous insects. 4. The evidence supporting each of these hypotheses is reviewed, and particular attention is paid to the Lepidoptera, as relevant life‐history data are rapidly accumulating for this ecologically and economically important group. 5. There is evidence at the interspecific level supporting: (i) a link between OI and a trade‐off between soma and non‐soma in Trichoptera and Hymenoptera (the proportionate allocation to soma decreases with increasing OI); (ii) a negative correlation between OI and dependency on external nutrient inputs (via adult feeding) in Hymenoptera and in Lepidoptera; (iii) a negative correlation between OI and the degree of polyandry (and nuptial gift, i.e. spermatophore, use) in Lepidoptera; (iv) negative correlations between OI and resource re‐allocation capabilities (egg and thoracic musculature resorption) in Hymenoptera and in Lepidoptera; (v) a negative correlation between lifespan and OI in Trichoptera, Hymenoptera, and Lepidoptera, indicating a cost of reproduction; (vi) a link between winglessness and an OI of one in Lepidoptera; (vii) a negative correlation between OI and the degree of female mobility in winged Lepidoptera; and (viii) a negative correlation between OI and larval diet breadth (as mediated by oviposition strategy) in Lepidoptera. 相似文献
84.
Current Status and Perspectives Regarding LNA‐Anti‐miR Oligonucleotides and microRNA miR‐21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer 下载免费PDF全文
85.
High Dose Supplementation of Vitamin D Affects Measures of Systemic Inflammation: Reductions in High Sensitivity C‐Reactive Protein Level and Neutrophil to Lymphocyte Ratio (NLR) Distribution 下载免费PDF全文
86.
The Potential Value of the PI3K/Akt/mTOR Signaling Pathway for Assessing Prognosis in Cervical Cancer and as a Target for Therapy 下载免费PDF全文
87.
88.
Maryam M. Binabaj Fereshteh Asgharzadeh Amir Avan Farzad Rahmani Atena Soleimani Mohammad R. Parizadeh Gordon A. Ferns Mikhail Ryzhikov Majid Khazaei Seyed M. Hassanian 《Journal of cellular physiology》2019,234(7):11654-11661
EW-7197 is a transforming growth factor-β type I receptor kinase inhibitor with potential anti-inflammatory and antifibrotic properties. Here, we investigate the potential therapeutic effects of EW-7197 in a murine model of ulcerative colitis. EW-7197 attenuated the colitis disease activity index by improving rectal bleeding, body weight, and degree of stool consistency. EW-7197 also reduced colorectal tissue damage and the colon histopathological score by reducing crypt loss, mucosal damage, and tissue inflammation. Moreover, EW-7197 appeared to ameliorate the inflammatory and fibrotic responses by reducing oxidative stress, reducing submucosal edema and inflammatory cell infiltration, downregulating proinflammatory and pro-fibrotic genes, and inhibiting excessive collagen deposition in inflamed and fibrotic ulcerative colitis tissues. These results suggest that EW-7197 has potentially useful therapeutic properties against colitis, with clinically translational potential of inhibiting key pathological responses of inflammation and fibrosis in patients with colitis. 相似文献
89.
Reyhaneh Moradi Marjaneh Majid Khazaei Gordon A. Ferns Amir Avan Seyed Hamid Aghaee-Bakhtiari 《Journal of cellular physiology》2019,234(3):2306-2316
Colorectal cancer (CRC) is one of the most common cancers globally. Despite recent advances in therapeutic approaches, this cancer continues to have a poor prognosis, particularly when diagnosed late. 5-Fluorouracil (5-FU) has been commonly prescribed for patients with CRC, but resistance to 5-FU is one of the main reasons for failure in the treatment of this condition. Recently, microRNAs (miRNAs) have been established as a means of modifying the signaling pathways involved in initiation and progression of CRC and their role as oncogene or tumor suppressor have been investigated in various studies. Moreover, miRNAs through various mechanisms play an important role in inducing tumor resistance or sensitivity to anticancer drugs. Detecting and targeting these mechanisms may be a new therapeutic approach. This review summarizes the current knowledge about the potential roles of miRNAs in 5-FU resistance, with particular emphasis on molecular mechanism involved. 相似文献
90.
Omid Reza Tamtaji Shokoofeh Borzabadi Majid Ghayour-Mobarhan Gordon Ferns Zatollah Asemi 《Journal of cellular biochemistry》2019,120(3):2774-2781
Cardiovascular disease (CVD) is an overall term that comprises a number of related pathologies, these include peripheral arterial disease, cerebrovascular disease, coronary heart disease (CHD), venous thromboembolism, and rheumatic and congenital heart diseases. Fatty acids in the diet have been reported to affect CVD. The OPG/RANKL/RANK system appears to have a role in CVD outcomes. However, there have been few studies on the impact of diet-gene interaction for effects of fatty acids consumption on the OPG/RANKL/RANK system in CVD. This review focuses on the effects of fatty acids on OPG/RANKL/RANK in CVD. 相似文献