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Seyyed Mohammad Reza Kazemi-Bajestani Majid Ghayour-Mobarhan Mahmoud Ebrahimi Mohsen Moohebati Habib Allah Esmaeili Mohammad Reza Parizadeh Rasol Aghacizadeh Gordon A A Ferns 《Journal of trace elements in medicine and biology》2007,21(1):22-28
BACKGROUND: An imbalance between zinc and copper metabolism has been reported to predispose to coronary artery disease (CAD) in Western populations, but there are little data for other racial groups. We have therefore investigated the association between serum copper and zinc, and CAD in Iranian subjects undergoing coronary angiography. METHODS: Serum copper, zinc, fasting lipid profile, and blood glucose levels were measured in 114 patients (67 male and 47 female) undergoing routine coronary angiogram. Anthropometric features including blood pressure were determined using standard procedures. Demographic characteristics, including menopausal status and smoking habit, were assessed by questionnaire. RESULTS: Male patients had lower serum copper (p<0.05), lower serum zinc (p<0.05), and higher serum zinc/copper ratio (p<0.05) than females. Serum copper and zinc concentrations were significantly lower in the subjects with angiographically defined CAD than those patients with a normal angiogram, although the zinc/copper ratio was higher in these patients (p<0.001). Serum copper (r=-0.303, p<0.001) and zinc (r=-0.250, p<0.01) concentrations were both inversely related to age, and copper was positively associated with fasting serum triglycerides (r=0.188, p<0.05). CONCLUSION: Serum copper and zinc concentrations were significantly lower in Iranian patients with abnormal versus those with a normal angiogram. However, the zinc/copper ratio was higher in patients with CAD compared to subjects without CAD. Serum zinc and copper concentrations appear to be influenced by several physiological factors including age and gender. 相似文献
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Targeting the tumor microenvironment as a potential therapeutic approach in colorectal cancer: Rational and progress 下载免费PDF全文
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Serum C‐reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice 下载免费PDF全文
Majid Ghayour‐Mobarhan Hamid Reza Rahimi Mohammad Tajfard Gordon Ferns 《Journal of cellular physiology》2018,233(11):8508-8525
Cardiovascular disease is the most common cause of morbidity and mortality globally. Epidemiological studies using high‐sensitivity assays for serum C‐reactive protein have shown a consistent association between cardiovascular disease risk and serum C‐reactive protein concentrations. C‐reactive protein is a biomarker for inflammation, and has been established in clinical practice as an independent risk factor for cardiovascular disease events. There is evidence that serum C‐reactive protein is an excellent biomarker of cardiovascular disease and is also an independent and strong predictor of adverse cardiovascular events. Further characterization of the impact and influence of lifestyle exposures and genetic variation on the C‐reactive protein response to cardiovascular disease events may have implications for the therapeutic approaches to reduce cardiovascular disease events. This review summarizes the studies that have examined the association between serum C‐reactive protein and the risk of cardiovascular disease. We also discuss the impact of independent factors and C‐reactive protein genetic polymorphisms on baseline plasma C‐reactive protein levels. 相似文献
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Current status and future prospective of Curcumin as a potential therapeutic agent in the treatment of colorectal cancer 下载免费PDF全文
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Genetic variation in the DNA repair pathway as a potential determinant of response to platinum‐based chemotherapy in breast cancer 下载免费PDF全文