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Arab-Nozari Milad Ahangar Nematollah Mohammadi Ebrahim Lorigooini Zahra Shokrzadeh Mohammad Amiri Fereshteh Talebpour Shaki Fatemeh 《Molecular biology reports》2020,47(9):6961-6972
Molecular Biology Reports - Aim of this study was to investigate the efficacy of Ginkgo Biloba (G.B) hydro-ethanolic extract against hepatotoxicity induced by combined exposure to cadmium (Cd) and... 相似文献
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Proton exchange between cells and medium is one of the most important factors affecting culture pH, and hence its prediction
is advantageous. In this research, proton exchange flux across the cell membrane was predicted using a genome-scale model.
Calculated proton exchange flux was then exploited as a criterion to predict the trends and intensities of pH changes in cultures
of Bacillus subtilis containing various C-sources, i.e. glucose, sucrose, glycerol, lactate, and citrate, as well as N-sources, i.e. ammonium chloride, sodium nitrate, urea, and histidine. The results showed that glucose, sucrose, and glycerol lowered culture
pH as compared to citrate and lactate, which raised it. With regard to N-sources, the model predicted that ammonium chloride
lowered culture pH while other sources raised pH. Furthermore, maximum theoretical biomass yield using the various C&N-sources
was calculated, and sensitivity of microbial growth to proton exchange flux was investigated using robustness analysis to
identify the effect of pH on growth of B. subtilis using different substrates. Finally, the effect of ammonium nitrate, a widely used nitrogen source, on growth of B. subtilis was studied. Experimental data obtained by cultivation of B. subtilis DSM 3256 on mineral salt media containing various C&N-sources were used to confirm model predictions. Model predictions were
in good agreement with the experimental results for all of the examined C-sources as well as ammonium chloride and sodium
nitrate as N-sources. However, the predictions for the N-sources urea and histidine showed deviations, possibly because these
two compounds serve as both C&N-sources. 相似文献