Effect of nitrogen concentration,source, and phosphate concentration on accumulation of biomass and calycosin-7-O-β-D-glucoside in Astragalus membranaceus adventitious roots

In Vitro Cellular & Developmental Biology - Plant - Calycosin-7-O-β-D-glucoside (CG), a methoxylated isoflavonoid in Astragalus membranaceus Fisch. (Bunge), has a wide range of biological...     

Study of the Compression Dynamics of a Fiber Liner with a Deuterated Target Mounted on the Axis

Plasma Physics Reports - Compression of a fiber array with a deuterated target mounted on its axis is studied at the Angara-5-1 facility (3.5 MA, 100 ns). Cylindrical arrays with an initial...     

Synthesis of Nitrogen Oxides in a Subthreshold Microwave Discharge in Air and in Air Mixtures with Methane

Plasma Physics Reports - A subthreshold discharge excited by a microwave beam in air at pressures close to atmospheric is studied as a plasmachemical method of nitrogen oxide (NOx) production. It...     

Quadratic Susceptibility of Strongly Inhomogeneous Magnetoactive Plasma

Plasma Physics Reports - The expression is obtained for the high-frequency quadratic susceptibility of the strongly inhomogeneous magnetoactive plasma, which describes the nonlinear coupling...     

The Status of the Stock and the Current Fishery for the Atka Mackerel,Pleurogrammus monopterygius (Pallas, 1810), in the Olyutorsky–Navarin Area,Bering Sea

Russian Journal of Marine Biology - The dynamics of the Atka mackerel stock in the Olyutorsky–Navarin area in 1994–2019 is inferred from bottom-trawl surveys, fishery statistics,...     

Full-Wave Modeling of Doppler Backscattering from Filaments

Plasma Physics Reports - It is recognized that the filaments have a significant effect on the anomalous energy and particle transport in the tokamak periphery. They are actively investigated using...     

Psoralen attenuates bleomycin‐induced pulmonary fibrosis in mice through inhibiting myofibroblast activation and collagen deposition

Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by excessive deposition of extracellular matrix (ECM) and chronic inflammation with limited therapeutic options. Psoralen, a major active component extracted from Psoralea corylifolia L. seed, has several biological effects. However, the role of psoralen in IPF is still unclear. Here, we hypothesized that psoralen played an essential role in IPF in the inhibition of fibroblast proliferation and inflammatory response. A murine model of IPF was established by injecting bleomycin (BLM) intratracheally, and psoralen was administered for 14 days from the 7^th to 21^st day after BLM injection. Our results demonstrated that psoralen treatment reduced body weight loss and improved the survival rate of mice with IPF. Histological and immunofluorescent examination showed that psoralen alleviated BLM‐induced lung parenchymal inflammatory and fibrotic alteration. Furthermore, psoralen inhibited proliferation and collagen synthesis of mouse fibroblasts and partially reversed BLM‐induced expression of α‐smooth muscle actin at both the tissue and cell level. Moreover, psoralen decreased the expression of transforming growth factor‐β1, interleukin‐1β, and tumor necrosis factor‐α in the lungs of BLM‐stimulated mice. Our results reveale for the first time that psoralen exerts therapeutic effects against IPF in a BLM‐induced murine model.     

The protective effects of grape seed procyanidin B2 against asporin mediates glycated low‐density lipoprotein induced‐cardiomyocyte apoptosis and fibrosis

The progression of diabetic cardiomyopathy is related to cardiomyocyte dysfunction and apoptosis. Our previous studies showed that asporin (ASPN) was significantly increased in the myocardium of db/db mice through proteomics, and grape seed procyanidin B2 (GSPB2) significantly inhibited the expression of ASPN in the heart of db/db mice. We report here that ASPN played a critical role in glycated low‐density lipoproteins (gly‐LDL) induced‐cardiomyocyte apoptosis. We found that gly‐LDL upregulated ASPN expression. ASPN increased H9C2 cardiomyocyte apoptosis with down‐regulation of Bcl‐2, upregulation of transforming growth factor‐β1, Bax, collagen III, fibronectin, and phosphorylation of smad2 and smad3. However, GSPB2 treatment reversed ASPN‐induced impairments in H9C2 cardiomyocytes. These results provide evidence for the cardioprotective action of GSPB2 against ASPN injury, and thus suggest a new target for fighting against diabetic cardiomyopathy.     

Overexpression of Small Heat Shock Protein LimHSP16.45 in Arabidopsis hsp17.6II Mutant Enhances Tolerance to Abiotic Stresses

Russian Journal of Plant Physiology - Organisms can produce heat shock proteins (HSPs) in response to elevated temperatures and other abiotic stresses. However, the function of HSPs, including...