全文获取类型
收费全文 | 145篇 |
免费 | 1篇 |
出版年
2022年 | 3篇 |
2021年 | 1篇 |
2020年 | 3篇 |
2019年 | 1篇 |
2018年 | 3篇 |
2017年 | 7篇 |
2016年 | 8篇 |
2015年 | 2篇 |
2014年 | 5篇 |
2013年 | 4篇 |
2012年 | 12篇 |
2011年 | 5篇 |
2010年 | 4篇 |
2009年 | 4篇 |
2008年 | 5篇 |
2007年 | 7篇 |
2006年 | 7篇 |
2005年 | 9篇 |
2004年 | 10篇 |
2003年 | 4篇 |
2002年 | 4篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 3篇 |
1998年 | 2篇 |
1996年 | 2篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1980年 | 1篇 |
1979年 | 2篇 |
1976年 | 2篇 |
1975年 | 2篇 |
1974年 | 2篇 |
1973年 | 1篇 |
1972年 | 2篇 |
1971年 | 1篇 |
1970年 | 2篇 |
1969年 | 2篇 |
1966年 | 1篇 |
排序方式: 共有146条查询结果,搜索用时 109 毫秒
101.
102.
103.
A. V. Berezhnov E. I. Fedotova M. N. Nenov V. P. Zinchenko V. V. Dynnik 《Biochemistry (Moscow) Supplemental Series A: Membrane and Cell Biology》2010,4(1):56-63
Ten to fifty micromoles of palmitoyl-L-carnitine (PC) or myristoyl-D,L-carnitine (MC) evoke a high-amplitude elevation of
cytosolic calcium level ([Ca2+]i), hypercontraction and cell death in the primary culture of rat ventricular myocytes. The lag period of this effect varies
within 2–8 min and depends on the mitochondrial capacity to accumulate Ca2+. Maximal level of Ca2+, attainable at the end of the lag period, depends on calcium concentration in the external medium and is mediated by plasma
membrane nonspecific permeability. Preincubation of cardiomyocytes with the inhibitors of phospholipase C, cytosolic phospholipase
A2 and/or Ca2+/calmodulin-dependent protein kinase II prevents cell death, increases lag period duration and reduces maximal [Ca2+]i. Both PC and MC, even at low concentrations (1–5 μM), dramatically increase the frequency of Ca2+-sparks and Ca2+-waves in cardiomyocytes and promote the formation of sustained microdomains with elevated calcium concentration. We discuss
possible mechanisms of Ca2+-microdomain formation, where the “vicious circle” of Ca2+-dependent phospholipases activation may arise. The “vicious circle” with combined autocatalytic action of Ca2+-dependent phospholipases may be implicated in hydrolysis of membrane phosphatidylcholine and subsequent induction of nonselective
permeability for Na+ and Ca2+ (lipid pore). 相似文献
104.
Semiokhina AF Fedotova IB Poletaeva II 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2006,56(3):298-316
Physiological, biochemical and genetic studies of audiogenic epilepsy in Krushinsky-Molodkina (KM) rat strain are analyzed. In brief, the history of KM strain selection and its current state are reviewed. Physiological mechanisms of the typical audiogenic seizure development and the audiogenic myoclonus (audiogenic kindling phenomena) are considered. The EEG correlates of these phenomena are presented. Biochemical features of the strain (neurotransmitter and neuronal membrane biochemistry) are described. 相似文献
105.
The aim of the present study was to explore the mood effects of D1 receptor agonist, SKF-38393 and D1 receptor antagonist, SCH-23390 alone or in combination with a low dose of 17β-estradiol (17β-E2) in the adult ovariectomized female rats (OVX). OVX rats of Wistar strain were used in all experiments. Two weeks after surgery rats were chronically treated with vehicle, a low dose of 17β-E2 (5.0 μg/rat), SKF-38393 (0.1 mg/kg), SCH-23390 (0.1 mg/kg), SKF-38393 plus 17β-E2 or SCH-23390 plus 17β-E2 for 14 days before the forced swimming test. We found that SCH-23390 significantly decreased immobility time in the OVX females. A combination of SCH-23390 with a low dose of 17β-E2 induced more profound decrease of immobility time in the OVX rats compared to the rats treated with SCH-23390 alone. On the contrary, SKF-38393 failed to modify depression-like behavior in the OVX rats. In addition, SKF-38393 significantly blocked the antidepressant-like effect of 17β-E2 in OVX rats. Thus, the D1 receptor antagonist SCH-23390 alone or in combination with a low dose of 17β-E2 exerted antidepressant-like effect in OVX female rats, while the D1 receptor agonist SKF-38393 produced depressant-like profile on OVX rats. 相似文献
106.
Yu. S. Fedotova Yu. F. Bogdanov S. A. Gadzhiyeva S. A. Sosnikhina V. G. Smirnov E. I. Mikhailova 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》1994,88(8):1029-1036
We studied the expression and inheritance of two spontaneous mutations found in different populations of rye Secale cereale L. that cause high univalent frequency in meiosis and low fertility. Both mutations were inherited as monogenic recessives. For each of the mutations the corresponding gene symbols (sy7 and sy10) were suggested although their allelism has not been studied. These mutants differ in chiasma frequency and in the number of univalents per meiocyte. Electron microscopy of the wholemount surface-spread synaptonemal complexes (SCs) from microsporocytes of both mutants revealed that during meiotic prophase I random synapsis began and progressed that involved not only homologous but also nonhomologous chromosomes. SCs were formed with frequent changes of pairing partners (switches) and intrachromosomal foldbacks of unpaired axial elements. As a result, incompletely synapsed, non-homologous and multivalent SCs were formed in mutants by the stage analogous to pachytene in normal plants. In sy7 a maximum in the number of switches and foldbacks were observed at zygotene, whereas in sy10 this occurred at pachytene. We suggest that it is the process of recognition of homology that is impaired in both mutants. This leads to indiscriminate synapsis and prevents chiasma formation. Both mutants may be classified as desynaptic. 相似文献
107.
A new genus and species of pedogenetic gall midge, Estoperpetua sakhalinica gen. et sp. nov., of the tribe Heteropezini (subfamily Lasiopterinae) is described. Gall midges have not been recorded in Eocene amber of Sakhalin. A female with 4-segmented tarsi, large transparent triangular sensoria on flagellomeres, short wings and legs, and long 2 + 9-segmented antennae is described. Heteropezidi shows the greatest generic and species diversity in the Late Eocene Rovno amber. Representatives of this supertribe were also found in the Late Eocene Baltic amber, Early Eocene Oise amber, Miocene amber from Mexico and Dominican Republic, and African copal. Heteropezidi from different amber faunas are reviewed. 相似文献
108.
Higher gall midges of the supertribe Mycodiplosidi, subfamily Cecidomyiinae, are recorded for the first time in Late Eocene Rovno amber. In other fossil resins, Mycodiplosidi have not yet been recorded. A male Rovnodiplosis eduardi gen. et sp. nov. (Mycodiplosidi), with distinctive binodose flagellomeres having long loopy sensilla is described. Species of Cecidomyiinae known from fossil resins are listed. 相似文献
109.
Martusevich A. K. Galka A. G. Tuzhilkin A. N. Golygina E. S. Fedotova A. S. Nazarov V. V. 《Biophysics》2022,67(1):106-110
Biophysics - Abstract—The purpose of this study was to assess the modification of the intrinsic crystal formation of blood serum under the action of alternating currents of different... 相似文献
110.
A comparative study of the effects of thyroid, adrenal, and gonadal deficit on capability for learning, retention of memory traces, and behavior was carried out in male rats under conditions of hormonal disbalance produced by extirpation of the endocrine glands. Behavior of animals was tested during the active and passive avoidance learning and in the open field. It was found out that the extirpation of the peripheral endocrine glands impairs learning and reproduction of the acquired reaction and alters the behavior. The results suggest that corticosteroid hormones take part in learning and behavior. Gonadal and thyroid hormones appear to exert a modulating influence on the higher nervous activity. 相似文献