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S1 nuclease hydrolysis and bezoylated naphthoylated DEAE-cellulose (BND-cellulose) chromatography have been used to demonstrate that alkylation of DNA by dimethyl sulfate at neutral pH leads to the production of partially denatured molecules under conditions where no significant depurination occurs. DNA was alkylated with increasing concentrations of the alkylating agent, and subjected to enzymatic degradation and binding to BND cellulose. An increasing degree of DNA hydrolysis and adherence to BND cellulose was seen. On hydroxyapatite chromatography the alkylated DNA still eluted at the position of double-stranded molecules suggesting the presence of partially denatured regions. The presence of salt had a preventive effect on such denaturation. 相似文献
13.
ObjectivesTo assess the prevalence of noncommunicable disease (NCD) risk factors among Saudi university employees and their families; to estimate the cardiovascular risk (CVR) amongst the study population in the following 10years.MethodsThe NCD risk factors prevalence was estimated using a cross-sectional approach for a sample of employees and their families aged ≥ 18 years old, in a Saudi university (Riyadh in Kingdom of Saudi Arabia; KSA). WHO STEPwise standardized tools were used to estimate NCD risk factors and the Framingham Coronary Heart Risk Score calculator was used to calculate the CVR.ResultsFive thousand and two hundred subjects were invited, of whom 4,500 participated in the study, providing a response rate of 87%. The mean age of participants was 39.3±13.4 years. The majority of participants reported low fruit/vegetables consumption (88%), and physically inactive (77%). More than two thirds of the cohort was found to be either overweight or obese (72%), where 36% were obese, and 59% had abdominal obesity. Of the total cohort, 22–37% were found to suffer from dyslipidaemia, 22% either diabetes or hypertension, with rather low reported current tobacco use (12%). One quarter of participants was estimated to have >10% risk to develop cardiovascular disease within the following 10-years.ConclusionThe prevalence of NCD risk factors was found to be substantially high among the university employees and their families in this study. 相似文献
14.
Mohyeddin Mandana Bonab Kamran Alimoghaddam Fatemeh Talebian Syed Hamid Ghaffari Ardeshir Ghavamzadeh Behrouz Nikbin 《BMC cell biology》2006,7(1):14-7
Background
A hot new topic in medical treatment is the use of mesenchymal stem cells (MSC) in therapy. The low frequency of this subpopulation of stem cells in bone marrow (BM) necessitates their in vitro expansion prior to clinical use. We evaluated the effect of long term culture on the senescence of these cells. 相似文献15.
Omid Haghighi Soheila Davaeifar Hossein Shahbani Zahiri Hadi Maleki Kambiz Akbari Noghabi 《International journal of peptide research and therapeutics》2020,26(2):783-793
Glutamate dehydrogenase (GDH), which is present in most bacteria and eukaryotes’ mitochondria, plays an important role in amino acid metabolism. In g 相似文献
16.
Mir Hadi Jazayeri Maryam Sadri Ali Mostafaie Reza Nedaeinia 《International journal of peptide research and therapeutics》2020,26(3):1251-1257
Kidney failure is one of the most important challenges in medicine. In this study, we used HEK-293 kidney cells to evaluate and compare changes in the expr 相似文献
17.
Pirkhezranian Zana Tanhaeian Abbas Mirzaii Mehdi Sekhavati Mohammad Hadi 《International journal of peptide research and therapeutics》2020,26(3):1503-1512
International Journal of Peptide Research and Therapeutics - Cancer remains one of the leading causes of death worldwide. Introduction of natural compounds with anticancer properties can be an... 相似文献
18.
Plasmonics - In this paper, we study the optical properties and surface plasmon resonance of a bimetallic core-shell spherical nanoparticle exhibiting monolayer graphene coatings. The extinction... 相似文献
19.
Abarghooi Kahaki Fatemeh Monzavi Sakineh Bamehr Hadi Bandani Eshagh Payandeh Zahra Jahangiri Abolfazl Khalili Saeed 《International journal of peptide research and therapeutics》2020,26(4):2077-2087
International Journal of Peptide Research and Therapeutics - Membrane proteins play important functions, such as cellular communication and transferring materials in the cell. Many membrane... 相似文献
20.
Ghamari Fatemeh Vaezi Golamhassan Khaksari Mehdi Hojati Vida 《International journal of peptide research and therapeutics》2020,26(4):2029-2038
International Journal of Peptide Research and Therapeutics - Fetal exposure to alcohol can cause a wide range of long-lasting physiological and behavioral effects, collectively referred to as fetal... 相似文献