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391.
Aram Yengoyan 《The Australian journal of anthropology》2004,15(2):224-226
Book reviewed in this article: John H. Zammito. Kant, Herder and the Birth of Anthropology. Andrew Zimmerman. Anthropology and Antihumanism in Imperial Germany. 相似文献
392.
393.
Davami F Sardari S Majidzadeh-A K Hemayatkar M Barkhordari F Enayati S Adeli A Mahboudi F 《BMB reports》2011,44(1):34-39
Resistance to PAI-1 is a factor which confers clinical benefits in thrombolytic therapy. The only US FDA approved PAI-1 resistant drug is Tenecteplase?. Deletion variants of t-PA have the advantage of fewer disulfide bonds in addition to higher plasma half lives. A new variant was developed by deletion of the first three domains in t-PA in addition to substitution of KHRR 128-131 amino acids with AAAA in truncated t-PA. The specific activity of this new variant, 570 IU/μg, was found to be similar to those found in full length t-PA (Alteplase?), 580 IU/μg. A 65% and 85% residual activity after inhibition by rPAI-1 was observed for full length and truncated-mutant form, respectively. This new variant as the first PAI-1 resistant truncated t-PA may offer more advantages in clinical conditions in which high PAI-1 levels makes the thrombolytic system prone to re-occlusion. 相似文献
394.
Farzaneh Darbeheshti Nima Rezaei Mahsa M. Amoli Yaser Mansoori Javad Tavakkoly Bazzaz 《Journal of cellular physiology》2019,234(12):22386-22399
395.
Javdani Moosa Habibi Atefeh Shirian Sadegh Kojouri Gholam Ali Hosseini Farzaneh 《Biological trace element research》2019,187(1):202-211
Biological Trace Element Research - Selenium is known to be a neuroprotective agent in respect to a number of neuronal diseases and pain. The aim of this study was to evaluate the neuroprotective... 相似文献
396.
Assi Hazem Tfayli Arafat Assaf Nada Daya Sarah Abou Bidikian Aram H. Kawsarani Dima Fermanian Puzant Zaatari Ghazi Mahfouz Rami 《Molecular biology reports》2019,46(4):3671-3676
Molecular Biology Reports - Lung adenocarcinoma patients have variable prognosis due to many factors. Detection of epidermal growth factor receptor (EGFR) activating mutations is one of the factors... 相似文献
397.
398.
Minoo Yaghmaei Saeedeh Salimi Lida Namazi Farzaneh Farajian-Mashhadi 《Genetics and molecular biology》2015,38(4):444-449
The aim of present study was to investigate the role of the X-ray repair
cross-complementing protein1 (XRCC1) and Tumor
protein p53 (Tp53) polymorphisms in Uterine Leiomyoma
(UL) susceptibility in southeastern Iran. This case control study was performed on
139 women with UL and 149 age, BMI and ethnicity matched healthy women. All women
were genotyped for the XRCC1 Arg399Gln, XRCC1
Arg194Trp and Tp53 Arg72Pro polymorphisms. The frequency of
Tp53 72 Pro/Pro genotype was significantly higher in UL women
compared to controls. The risk of UL was 1.5 fold higher in women with the Pro/Pro
genotype (OR, 1.5 [95% CI, 1.1 to 2.1], p = 0.012). Moreover, the frequency of the
Pro allele was significantly higher in the UL women. Although the frequency of
XRCC1 Arg399Gln genotypes did not significantly differ between UL
and control groups before adjusting for age, there was an association between the
XRCC1 Arg/Gln genotype and UL after adjusting for age (OR, 1.8
[95% CI, 1.1 to 3]). No association was observed between the XRCC1
Arg194Trp polymorphism and UL. The Pro/Pro genotype of Tp53 Arg72Pro
polymorphism was associated with UL susceptibility. In addition, the
XRCC1 Arg/Gln genotype was associated with increased risk of UL
after adjusting for age. 相似文献
399.
Wen-Chi Pan Melissa N. Eliot Petros Koutrakis Brent A. Coull Farzaneh A. Sorond Gregory A. Wellenius 《PloS one》2015,10(8)
Background and Purpose
Some prior studies have linked ambient temperature with risk of cerebrovascular events. If causal, the pathophysiologic mechanisms underlying this putative association remain unknown. Temperature-related changes in cerebral vascular function may play a role, but this hypothesis has not been previously evaluated.Methods
We evaluated the association between ambient temperature and cerebral vascular function among 432 participants ≥65 years old from the MOBILIZE Boston Study with data on cerebrovascular blood flow, cerebrovascular resistance, and cerebrovascular reactivity in the middle cerebral artery. We used linear regression models to assess the association of mean ambient temperature in the previous 1 to 28 days with cerebrovascular hemodynamics adjusting for potential confounding factors.Results
A 10°C increase in the 21-day moving average of ambient temperature was associated with a 10.1% (95% confidence interval [CI], 2.2%, 17.3%) lower blood flow velocity, a 9.0% (95% CI, 0.7%, 18.0%) higher cerebrovascular resistance, and a 15.3% (95%CI, 2.7%, 26.4%) lower cerebral vasoreactivity. Further adjustment for ozone and fine particulate matter (PM2.5) did not materially alter the results. However, we found statistically significant interactions between ambient temperature and PM2.5 such that the association between temperature and blood flow velocity was attenuated at higher levels of PM2.5.Conclusions
In this elderly population, we found that ambient temperature was negatively associated with cerebral blood flow velocity and cerebrovascular vasoreactivity and positively associated with cerebrovascular resistance. Changes in vascular function may partly underlie the observed associations between ambient temperature and risk of cerebrovascular events. 相似文献400.
Sulforaphane (SFN) is an isothiocyanate found in cruciferous vegetables with anti-inflammatory, anti-oxidant and anti-cancer activities. However, the antioxidant and anticancer mechanism of sulforaphane is not well understood. In the present research, we reported binding modes, binding constants and stability of SFN–DNA and -RNA complexes by Fourier transform infrared (FTIR) and UV–Visible spectroscopic methods. Spectroscopic evidence showed DNA intercalation with some degree of groove binding. SFN binds minor and major grooves of DNA and backbone phosphate (PO2), while RNA binding is through G, U, A bases with some degree of SFN–phosphate (PO2) interaction. Overall binding constants were estimated to be K(SFN–DNA)=3.01 (± 0.035)×104 M-1 and K(SFN–RNA)= 6.63 (±0.042)×103 M-1. At high SFN concentration (SFN/RNA = 1/1), DNA conformation changed from B to A occurred, while RNA remained in A-family structure. 相似文献