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Farzad Hadaegh Mitra Hasheminia Hengameh Abdi Davood Khalili Mohammadreza Bozorgmanesh Banafsheh Arshi Fereidoun Azizi 《PloS one》2015,10(10)
ObjectivePrehypertension is associated with cardiovascular disease (CVD). There is no study to examine the incidence and risk factors of prehypertension in a sex stratified setting. The aim of this study was to examine the effect modification of sex for different risk factors which predicts the progression from normotension to prehypertension in a Middle East population-based cohort, during a median follow-up of 9.2 years.MethodsA multivariate Cox analysis was performed among 1466 and 2131 Iranian men and women, respectively, who were free of prehypertension, hypertension, CVD and diabetes at baseline and free of incident hypertension without preceding prehypertension at follow-up. Incident prehypertension at follow-up was defined as systolic blood pressure (SBP) of 120–139 mmHg and/or diastolic blood pressure (DBP) of 80–89 mmHg.ResultsOverall, 1440 new cases of prehypertension were identified resulting in an incidence rate of 593/10000 person-years; the corresponding values for women and men were 489/10000 and 764/10000person-years, respectively. There were significant interactions between gender with age, DBP, waist-to-hip-ratio (WHpR) and estimated glomerular filtration rate (eGFR) (all P-values <0.05) in multivariate analysis. Strong associations were found between age, body mass index (BMI) and SBP with incident prehypertension in both genders. However, the effect of DBP and WHpR was significant among women and 2-hour post challenge plasma glucose (2h-PCPG)was an independent risk factor for men. In the sex-adjusted analysis, glomerular hyperfiltration [Hazard ratio (HR) and 95%CI: 1.01 (1.00–1.01), P-value = 0.02], age, BMI, WHpR, SBP and DBP had higher risks while being female [HR (95%CI): 0.81(0.69–0.94), P-value = 0.01] had a lower risk for incident prehypertension.ConclusionAccording to this study results, among Iranian population with high incidence of prehypertension, general adiposity and glomerular hyperfiltration in total, 2h-PCPG in men and central adiposity in women should be emphasized as risk factors for prehypertension. 相似文献
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Fadaei Reza Shateri Hossein DiStefano Johanna K. Moradi Nariman Mohammadi Mohammad Emami Farzad Aghajani Hassan Ziamajidi Nasrin 《Molecular and cellular biochemistry》2020,469(1-2):29-39
Molecular and Cellular Biochemistry - Bac Coronary artery disease (CAD) is the leading cause of death worldwide and most commonly develops as a result of atherosclerosis. ANGPTL8 is a secreted... 相似文献
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Mohammad Vatanparast Fatemeh Hosseininaveh Farzad Pakarpour 《Archives Of Phytopathology And Plant Protection》2013,46(14):1390-1398
Adults of Eurygaster integriceps were collected from the wheat field, dissected and their midguts and salivary glands were removed out. After centrifugation of the homogenates, the resulted supernatants were used as the source of enzyme. Pectinase activity was assayed using agarose plate and colorimetric assays. Pectinesterase and polygalacturonase activity was detected in the first and fourth part of the midgut, respectively. Colorimetric assays revealed more pectinase activity in the first part than the fourth part. No activity was detected in the salivary gland. Optimal pH for pectinase activity in the first part of the midgut was determined at pH set of 3, 4, 5, 6, 7, 8, 9 and 10. The results showed the optimum pH for pectinases occurred at pH 6. Maximum activity for the enzyme incubated at 20,30,35,40, 45, 50, 60, 70, 80, 90 and 100°C for 60 min was observed at 50°C. This is the first report of the presence of pectinases in a scutellerid bug. 相似文献
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Farzad Aala Umi Kalsom Yusuf Farida Jamal Alireza Khodavandi 《World journal of microbiology & biotechnology》2010,26(12):2193-2198
Dermatophytes are a group of fungi able to invade keratinized tissues of humans and animals, causing dermatomycosis. Azole
antifungal drugs are commonly used in the treatment of dermatomycosis. However, this group of chemicals is known to cause
side effects in patients and due to increased use of these medications, azoles are known to cause drug resistance. Having
said this, the purpose of the present study was to investigate an alternative anti dermatophyte which is plant based. In this
study, allicin, which is a pure bioactive compound isolated from garlic, was tested for its potential as a treatment of dermatomycosis.
The study evaluated the in vitro efficacy of pure allicin used alone against ten isolates of Trichophyton rubrum and it was found that the MIC50 and MIC90 ranged from 0.78–25.0 μg/ml, whereas the MIC values for ketoconazole and fluconazole ranged from 0.25–8.0 and 1.0–32.0 μg/ml,
respectively, at 28°C for both 7 and 10 days incubation. On the other hand, time–kill studies revealed that the antifungicidal
effect of allicin became active within 12–24 h of management in vitro and that it was as good as that of ketoconazole. Finally,
most of the tested drug combinations demonstrated synergistic or additive interactions for all isolates for both 7 and 10 days
incubation at 28°C. In conclusion, when used alone, allicin showed very good potential as an antifungal compound against mycoses-causing
dermatophytes, performing better than the synthetic drug fluconazole and almost as good as ketoconazole. Furthermore, allicin
in combination with ketoconazole or with fluconazole frequently showed synergistic or additive interactions against dermatomycosis. 相似文献
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Alireza Khodavandi Fahimeh Alizadeh Farzad Aala Zamberi Sekawi Pei Pei Chong 《Mycopathologia》2010,169(4):287-295
Candidiasis is a term describing infections by yeasts from the genus Candida, and the type of infection encompassed by candidiasis ranges from superficial to systemic. Treatment of such infections often
requires antifungals such as the azoles, but increased use of these drugs has led to selection of yeasts with increased resistance
to these drugs. In this study, we used allicin, an allyl sulfur derivative of garlic, to demonstrate both its intrinsic antifungal
activity and its synergy with the azoles, in the treatment of these yeasts in vitro. In this study, the MIC50 and MIC90 of allicin alone against six Candida spp. ranged from 0.05 to 25 μg/ml. However, when allicin was used in combination with fluconazole or ketoconazole, the MICs
were decreased in some isolates. Our results demonstrated the existing synergistic effect between allicin and azoles in some
of the Candida spp. such as C. albicans, C. glabrata and C. tropicalis, but synergy was not demonstrated in the majority of Candida spp. tested. Nonetheless, In vivo testing needs to be performed to support these findings. 相似文献
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Genome-wide linkage analysis of a Parkinsonian-pyramidal syndrome pedigree by 500 K SNP arrays
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Shojaee S Sina F Banihosseini SS Kazemi MH Kalhor R Shahidi GA Fakhrai-Rad H Ronaghi M Elahi E 《American journal of human genetics》2008,82(6):1375-1384
Robust SNP genotyping technologies and data analysis programs have encouraged researchers in recent years to use SNPs for linkage studies. Platforms used to date have been 10 K chip arrays, but the possible value of interrogating SNPs at higher densities has been considered. Here, we present a genome-wide linkage analysis by means of a 500 K SNP platform. The analysis was done on a large pedigree affected with Parkinsonian-pyramidal syndrome (PPS), and the results showed linkage to chromosome 22. Sequencing of candidate genes revealed a disease-associated homozygous variation (R378G) in FBXO7. FBXO7 codes for a member of the F-box family of proteins, all of which may have a role in the ubiquitin-proteosome protein-degradation pathway. This pathway has been implicated in various neurodegenerative diseases, and identification of FBXO7 as the causative gene of PPS is expected to shed new light on its role. The performance of the array was assessed and systematic analysis of effects of SNP density reduction was performed with the real experimental data. Our results suggest that linkage in our pedigree may have been missed had we used chips containing less than 100,000 SNPs across the genome. 相似文献
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Vassiliou E Sharma V Jing H Sheibanie F Ganea D 《Journal of immunology (Baltimore, Md. : 1950)》2004,173(11):6955-6964
Since dendritic cells (DC) participate in both innate and adaptive immunity, their survival and expansion is tightly controlled. Little is known about the mechanisms of DC apoptosis. PGE(2), an arachidonic acid metabolite, plays an essential role in DC migration. We propose a novel function for PGE(2) as a DC survival factor. Our studies demonstrate that PGE(2) protects DC in vitro against apoptosis induced by withdrawal of growth factors or ceramide. DC matured in conditions that inhibit endogenous PGE(2) release are highly susceptible to apoptosis and exogenous PGE(2) re-establishes the more resistant phenotype. The antiapoptotic effect is mediated through EP-2/EP-4 receptors and involves the PI3K --> Akt pathway. PGE(2) leads to increased phosphorylation of Akt, protection against mitochondrial membrane compromise, and decreased caspase 3 activity. Macroarray data indicate that PGE(2) leads to the down-regulation of a number of proapoptotic molecules, i.e., BAD, several caspases, and granzyme B. In vivo, higher numbers of immature and Ag-loaded CFSE-labeled DC are present in the draining lymph nodes of mice inoculated with PGE(2) receptor agonists, compared with animals treated with ibuprofen or controls injected with PBS. This suggests that PGE(2) acts as an endogenous antiapoptotic factor for DC and raises the possibility of using PGE(2) agonists to increase the survival of Ag-loaded DC following in vivo administration. 相似文献