ICI 182,780 has agonistic effects and synergizes with estradiol-17 beta in fish liver, but not in testis

Background  

ICI 182,780 (ICI) belongs to a new class of antiestrogens developed to be pure estrogen antagonists and, in addition to its therapeutic use, it has been used to knock-out estrogen and estrogen receptor (ER) actions in several mammalian species. In the present study, the effects and mechanism of action of ICI were investigated in the teleost fish, sea bream (Sparus auratus).     

Human MC4R variants affect endocytosis,trafficking and dimerization revealing multiple cellular mechanisms involved in weight regulation

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Characterization and Hazard Study of Two Areas of Penang Island,Malaysia

Penang Island of Malaysia is vulnerable to various natural hazards due to its hilly terrain and weather. Due to recent rapid population and economic growth, the probability of disaster associated with natural hazards has increased. This article characterizes geological and geotechnical parameters collected from field data that relate to natural hazard susceptibility. The areas of investigation were chosen so that each area lay on different geological formations. The variations in selected parameters with depth were obtained. The correlation within parameters was established and was found to be in agreement with that from other researchers. The investigation identifies parameters that can be used to evaluate the degree of hazard susceptibility.